Abstract:
OBJECTIVE:Innovative skin substitutes and temporary wound dressings are frequently used in the treatment of superficial and partial-thickness wounds. The aim of this study was to compare 2 commonly used temporary skin dressings with a newly developed collagen matrix to determine changes in microcirculation as measured by blood flow, hemoglobin oxygenation, and relative hemoglobin values during healing of partial-thickness skin defects. METHODS:This animal study involved 28 adult male Lewis rats. On the back of each rat, 2 standardized partial-thickness skin defects were generated through a skin dermatome (n = 56). Then, wounds were treated with polylactide-based copolymer skin substitute (Suprathel, PolyMedics, Denkendorf, Germany; n = 14), biosynthetic skin dressing (Biobrane, Smith & Nephew, Hamburg, Germany; n = 14), or Collagen Cell Carrier (CCC; Naturin Viscofan, Weinheim, Germany; n = 14). The remaining control wounds were left untreated (n = 14). MAIN OUTCOME MEASURES:Perfusion dynamics were assessed every 10 days for 80 days with the O2C device (LEA Medizintechnik, Gieβen, Germany) to determine blood flow, hemoglobin oxygenation, and relative amount of hemoglobin. MAIN RESULTS:Blood flow was increased in all wounds for at least 30 days after wound generation. The relative amounts of hemoglobin were increased in superficial layers (2 mm) for 10 to 20 days. Hemoglobin oxygenation in the superficial layers decreased in the polylactide-based copolymer skin substitute and biosynthetic skin dressing-treated groups and initially increased in the untreated wounds and CCC groups on day 10; these values also decreased. CONCLUSIONS:The presented results demonstrate the complex changes in microcirculation in the course of healing partial-thickness wounds with different wound dressings and contribute to a better understanding of these wounds. However, based on the results of the study, a clear recommendation for a specific substitute is not yet possible.
journal_name
Adv Skin Wound Carejournal_title
Advances in skin & wound careauthors
Held M,Medved F,Petersen W,Tolzmann DS,Rahmanian-Schwarz A,Schaller HE,Rothenberger Jdoi
10.1097/01.ASW.0000525848.21221.b8subject
Has Abstractpub_date
2017-11-01 00:00:00pages
517-521issue
11eissn
1527-7941issn
1538-8654pii
00129334-201711000-00006journal_volume
30pub_type
杂志文章abstract:OBJECTIVE:The objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment. DESIGN:Retrospective. SETTING:Plastic surgery office-based outpatient setting in New York City. PATIENTS:Forty patients with 44 keloid scars requiring surgical excision....
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000482993.64811.74
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence and risk factors of pressure injury (PI) development after ventricular assist device (VAD) or total artificial heart (TAH) surgery. METHODS:The investigator reviewed all VAD-TAH surgeries performed between 2010 and 2018 in a large academic health system. The PIs were reported by ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000717236.91761.78
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To describe venous ulcer care and wound care practices in Gauteng, a province of South Africa, according to the Donabedian structure-process-outcome quality improvement model. METHODS:Forty-eight facilities were selected randomly from public and private wound care practices in Gauteng. Structured interviews ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000617848.46377.ae
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Bitter melon is a plant fruit that has been shown to exert a hypoglycemic effect when used systemically in patients with diabetes. This study was designed to investigate the topical effect of bitter melon on diabetic wounds using the wound chamber model in rats. DESIGN:Two bilateral wound chambers were impla...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000504758.86737.76
更新日期:2017-01-01 00:00:00
abstract:GENERAL PURPOSE:To review what is known about pediatric pressure injuries (PIs) and the specific factors that make neonates and children vulnerable. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound ca...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000577124.58253.66
更新日期:2019-09-01 00:00:00
abstract::Among lower extremity chronic wounds, heel ulcers present one of the greatest challenges to the wound care provider. The potential for these ulcers to progress to osteomyelitis of the calcaneus is well known. The concept of "what to take off the wound" is a known clinical axiom; however, extensive debridement or surgi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000323504.68401.d6
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the influence of a biosynthetic cellulose wound dressing (BWD) to stimulate wound healing in patients with a venous leg ulcer on periulcer skin condition when compared with standard care using a foam dressing. METHODS:Each patient with a venous ulcer received compres...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000431237.22658.15
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:: The purpose of this study was to assess Inlow's 60-Second Diabetic Foot Screen Tool to ascertain consistency of risk recognition for development of ulceration independent of specific assessor and practice setting. Screening tools that assist clinicians in identifying risk require validation. The objectives ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000415343.45178.91
更新日期:2012-06-01 00:00:00
abstract:GENERAL PURPOSE:The purpose of this learning activity is to provide information about the Healthy Foot Screen, a new tool for assessment of common foot abnormalities. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000530686.16243.d5
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To determine whether prostaglandin E2 improves angiogenesis in full-thickness skin grafts. DESIGN:Randomized study SUBJECTS:20 male rabbits, divided into 2 experimental and 2 control groups. METHODOLOGY:Prostaglandin E2 (experimental groups) or prostaglandin E2 vehicle (control groups) was injected locally...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/00129334-200405000-00020
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to determine if the use of locally implanted, synthetic calcium sulfate tablets, impregnated with antibiotics, can heal lower-extremity osteomyelitis, without the use of oral and/or intravenous antibiotics or wound complications associated with similarly used mined or refined ca...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000407647.12832.6c
更新日期:2011-11-01 00:00:00
abstract:GENERAL PURPOSE:To present an evaluation of a surfactant-containing polymeric membrane foam wound dressing for use on patients with chronic pilonidal sinus disease. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000534702.34915.90
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:The aim of this scientific study was to assess epidermal micrografts for formation at the dermal-epidermal (DE) junction, cellular outgrowth, and growth factor secretion. Epidermal harvesting is an autologous option that removes only the superficial epidermal layer of the skin, considerably limiting donor sit...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000470024.81711.b8
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To determine what factors increase the risk of early wound complications in patients undergoing direct anterior total hip arthroplasty whose wounds were closed with 2-octyl cyanoacrylate with mesh. METHODS:This study was a retrospective review of 75 consecutive patients who underwent direct anterior total hi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000613544.11947.8b
更新日期:2020-01-01 00:00:00
abstract::Bed positioning poses a subtle, yet important, tradeoff in the competing needs of hospitalized patients, particularly those susceptible to lower respiratory tract infections and/or pressure ulcers. Although it is widely held that a minimum 30° incline is necessary to mitigate risk of ventilator-acquired pneumonia, it ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000471877.19459.85
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to test the efficacy of a wound support network model between the primary home care service and the hospital. The impact on wound healing rate, cost benefit, and transfer of knowledge was investigated. INTERVENTION:The intervention group was exposed to a wound support network (n = 3...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000499714.97688.4b
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess and compare the efficacy of high-voltage electrical stimulation (HVES) with ultrasound (US) in treating Stage II through Stage IV pressure ulcers (PrUs)* of hospitalized patients. DESIGN:This study was designed as a prospective, controlled trial in which patients were rand...
journal_title:Advances in skin & wound care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.ASW.0000526606.72489.99
更新日期:2017-12-01 00:00:00
abstract::Laparoscopic bowel surgery has demonstrated patient care benefits of decreased duration of hospital stay, smaller incisions, lower risk of cardiopulmonary complications, and reduced risk of small-bowel obstruction. Resection of complicated diverticular disease and inflammatory bowel disease can be technically challeng...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/00129334-200211000-00009
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To provide the practitioner with current information on the most common nail disorders. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in wound care and related disorders. OBJECTIVES:After reading this article and taking this test, the reader should b...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000276409.53632.42
更新日期:2007-06-01 00:00:00
abstract::Thromboangiitis obliterans, or Buerger disease, is a rare nonatherosclerotic segmental inflammatory vasculitis that generally affects young tobacco smokers. Although no surgical treatment is available, the most effective way to halt the disease's progress is smoking cessation. In this case report, a 29-year-old smoker...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000604192.77577.6f
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To conduct a cost-of-illness study of pressure ulcers in the Netherlands for different care settings, including home care, nursing homes, general hospitals, and university hospitals. DESIGN:A cost-of-illness study was conducted based on prevalence figures and expert opinion. A differential cost study approac...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/00129334-200203000-00008
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:Research suggests that active Leptospermum honey (ALH) improves outcomes in patients with partial-thickness burns by enhancing healing and reepithelialization rates, as well as by protecting against antibiotic-resistant microorganisms. This study assessed the effectiveness of ALH gel on healing time, bacteria...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000484666.83140.b0
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:Infected or contaminated wound sites have historically been managed with incision and drainage. Here, the authors review their experience with skin closure over vessel loops and assess the results of this technique in a variety of clinical situations, hypothesizing that minimally invasive drainage strategies ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000694132.20581.ef
更新日期:2020-11-01 00:00:00
abstract::The purpose of this study was to evaluate whether any of the Braden subscales were more strongly related to pressure ulcer occurrence than the Braden total score in obese and nonobese hospitalized patients. The authors investigated whether defining high risk for the total Braden score of 16 or less was associated with...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000437641.22278.67
更新日期:2014-01-01 00:00:00
abstract::Primary and metastatic malignancies may occasionally mimic or coexist with cutaneous fungal infections. The authors report 3 cases of cancers that were initially presumed to be cutaneous fungal infections. Dermatologists should maintain a low threshold for skin biopsy in patients with persistent or refractory fungal i...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000446864.26807.43
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To assess the incidence of and risk factors for pressure ulcers among patients with advanced human immunodeficiency virus type 1 (HIV-1) infection. DESIGN:Multicenter trial that included 1258 consecutive patients infected with HIV-1 who had 1815 admissions to 16 acute care infectious disease units in Italy. ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/00129334-200406000-00011
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:The objective of this multicenter study was to prospectively evaluate the healing outcomes of chronic diabetic foot ulcers (DFUs) treated with PriMatrix (TEI Biosciences, Boston, Massachusetts), a fetal bovine acellular dermal matrix. METHODS:Inclusion criteria required the subjects to have a chronic DFU tha...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ASW.0000451891.87020.69
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Genital trauma during vaginal delivery may result from episiotomy, spontaneous perineal tears (perineum, vagina), or both. In 2012, this study aimed to investigate the effect of warm compress bistage intervention on the rate of episiotomy, perineal trauma, and postpartum pain intensity in the primiparous wom...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000476073.96442.91
更新日期:2016-02-01 00:00:00
abstract::Wound care professionals should carefully inspect and audit their coding and billing practices in light of (1) the OIG's 2014 Semiannual Report to Congress and (2) the 2015 OIG Work Plan.You can read the details of both documents by following the Internet links provided earlier in this article. Conducting those self-a...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000459891.21303.0f
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To examine the effect of arginine supplementation on wound healing, as measured by wound size and healing rate, in older adults in acute and long-term care (LTC) settings. DATA SOURCES:PubMed, CINAHL Plus, Google Scholar, and OpenGrey databases. STUDY SELECTION:Randomized clinical trials and clinical studie...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000579700.20404.56
更新日期:2019-10-01 00:00:00