Abstract:
OBJECTIVE:The objective of the study was to determine if the use of locally implanted, synthetic calcium sulfate tablets, impregnated with antibiotics, can heal lower-extremity osteomyelitis, without the use of oral and/or intravenous antibiotics or wound complications associated with similarly used mined or refined calcium sulfate. PATIENTS:Over a 5-year period, 354 patients with clinically confirmed osteomyelitis of the lower extremity were evaluated, and 337 met the inclusion criteria; 14 were lost to follow-up. METHODS:Devitalized or infected bone was debrided to the level of healthy cancellous and cortical bone. Compromised soft tissue was resected. At the onset of each operative encounter, the synthetic calcium sulfate tablets were mixed with a standard antibiotic mixture: 500 mg of powdered vancomycin mixed into 240 mg of gentamicin (normally supplied as a liquid in a concentration of 80 mg/2 mL). Vancomycin and gentamicin were chosen because they cover a broad spectrum of both gram-positive and gram-negative bacteria. RESULTS:A total of 279 of 323 patents (86.4%) clinically healed without the use of intravenous antibiotics following surgical debridement and tablet implantation. In addition, 24/323 (7.4%) required the use of intravenous antibiotics, but still healed; 20/323 (6.2%) required amputation, of which, 12 (3.7%) were digital amputations, 2 (0.6%) were ray amputations, and 6 (1.9%) were below-knee amputations. CONCLUSIONS:The use of locally implanted antibiotic-impregnated, synthetic calcium sulfate tablets in the surgical debridement site for bone infections of the lower extremity, without the concurrent use of intravenous antibiotics, has shown encouraging results.
journal_name
Adv Skin Wound Carejournal_title
Advances in skin & wound careauthors
Gauland Cdoi
10.1097/01.ASW.0000407647.12832.6csubject
Has Abstractpub_date
2011-11-01 00:00:00pages
515-23issue
11eissn
1527-7941issn
1538-8654pii
00129334-201111000-00008journal_volume
24pub_type
杂志文章abstract:OBJECTIVE:A recently described technique proposes a simple method to achieve permanent hemostasis of distal fingertip dermal avulsion injuries. It is simple to learn and easy to perform with readily available materials found in most emergency departments. However, long-term outcomes for patients treated with this techn...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000521049.72160.37
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To evaluate performance of a new silicone tape among clinicians caring for patients with fragile skin. DESIGN:An international, multisite, 2-week-use evaluation. PARTICIPANTS AND SETTINGS:Caregivers (n = 217) from acute care hospitals in the United States, United Kingdom, and France who regularly use tapes ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ASW.0000444646.43044.df
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To examine the effect of arginine supplementation on wound healing, as measured by wound size and healing rate, in older adults in acute and long-term care (LTC) settings. DATA SOURCES:PubMed, CINAHL Plus, Google Scholar, and OpenGrey databases. STUDY SELECTION:Randomized clinical trials and clinical studie...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000579700.20404.56
更新日期:2019-10-01 00:00:00
abstract::Primary and metastatic malignancies may occasionally mimic or coexist with cutaneous fungal infections. The authors report 3 cases of cancers that were initially presumed to be cutaneous fungal infections. Dermatologists should maintain a low threshold for skin biopsy in patients with persistent or refractory fungal i...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000446864.26807.43
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:To provide an overview of moisture management and its importance in wound care. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES:After participating in this educational activity, the participant should be better able t...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000470851.27030.98
更新日期:2015-10-01 00:00:00
abstract::The purpose of this study was to evaluate whether any of the Braden subscales were more strongly related to pressure ulcer occurrence than the Braden total score in obese and nonobese hospitalized patients. The authors investigated whether defining high risk for the total Braden score of 16 or less was associated with...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000437641.22278.67
更新日期:2014-01-01 00:00:00
abstract:PROBLEM:The diabetic population is at an increased risk, up to 15% over a lifetime, to develop leg and foot ulcers due to such factors as neuropathy, ischemia, and infection. The tight control of glucose levels as possible is necessary to prevent the diabetic complications by preventing microvascular changes that predi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000358639.45784.cd
更新日期:2009-08-01 00:00:00
abstract:GENERAL PURPOSE:To present a systematic review of the literature assessing the efficacy of monitoring devices for reducing the risk of developing pressure injuries. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.ASW.0000504579.83707.f6
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:This study was conducted to: (1) determine the clinical effectiveness of a low-air-loss surface, VersaCare P500, in the prevention of pressure ulcers in surgical patients; (2) determine differences in the adjusted Braden scores between those using VersaCare and VersaCare P500 mattress surfaces; and (3) explor...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000396303.13582.70
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:: The purpose of this study was to assess Inlow's 60-Second Diabetic Foot Screen Tool to ascertain consistency of risk recognition for development of ulceration independent of specific assessor and practice setting. Screening tools that assist clinicians in identifying risk require validation. The objectives ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000415343.45178.91
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment. DESIGN:Retrospective. SETTING:Plastic surgery office-based outpatient setting in New York City. PATIENTS:Forty patients with 44 keloid scars requiring surgical excision....
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000482993.64811.74
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To describe the care of pediatric patients who had a gastrostomy and developed peristomal lesions and received a systematic single adapted crusting technique in a pediatric ICU in a tertiary Brazilian hospital. METHODS:An analysis of six cases presenting traumatic, noninfectious peristomal lesions with ostiu...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000661788.68292.81
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess and compare the efficacy of high-voltage electrical stimulation (HVES) with ultrasound (US) in treating Stage II through Stage IV pressure ulcers (PrUs)* of hospitalized patients. DESIGN:This study was designed as a prospective, controlled trial in which patients were rand...
journal_title:Advances in skin & wound care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.ASW.0000526606.72489.99
更新日期:2017-12-01 00:00:00
abstract::Wound care professionals should carefully inspect and audit their coding and billing practices in light of (1) the OIG's 2014 Semiannual Report to Congress and (2) the 2015 OIG Work Plan.You can read the details of both documents by following the Internet links provided earlier in this article. Conducting those self-a...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000459891.21303.0f
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:A continuing complication, pressure injuries are due to sustained mechanical loading and tissue deformations, which can then be exacerbated by additional intrinsic and extrinsic risk factors. Although support surfaces are designed to mitigate risk factors for pressure injuries, the presence of a turn and pos...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000696412.04000.98
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of different dressing methods on the wound healing process after pilonidal sinus surgery. METHODS:In this clinical trial, 60 patients undergoing pilonidal sinus surgery were randomly assigned to one of three groups. In the first group, hydrogel or alginate and hydrocolloid compounds we...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000558268.59745.d2
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence and risk factors of pressure injury (PI) development after ventricular assist device (VAD) or total artificial heart (TAH) surgery. METHODS:The investigator reviewed all VAD-TAH surgeries performed between 2010 and 2018 in a large academic health system. The PIs were reported by ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000717236.91761.78
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To assess pressure ulcer (PU) risk in persons with mobility impairments using a large data set to identify demographic, laboratory, hemodynamic, and pharmacologic risk factors. METHODS:The cohort of interest was persons with disabilities who have mobility impairments and are diagnostically at risk of PUs. To...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000653152.36482.7d
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Genital trauma during vaginal delivery may result from episiotomy, spontaneous perineal tears (perineum, vagina), or both. In 2012, this study aimed to investigate the effect of warm compress bistage intervention on the rate of episiotomy, perineal trauma, and postpartum pain intensity in the primiparous wom...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000476073.96442.91
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To compare the cytotoxicities and efficacy of hyaluronan (HA), carbomer, and sodium alginate on repairing thermal-injured cells and promoting cell migration. DESIGN:The 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetra-zoliumromide method was used to evaluate the cytotoxicities of HA, carbomer, and sodium a...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000467303.39079.59
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:The goal of the present study was to evaluate the effects of hydroalcoholic extract-based carboxy methyl cellulose (CMC) gel of Punica granatum peel (PCMC) and CMC on healing of full-thickness skin wounds. MATERIALS AND METHODS:Forty-two rats were studied. Each rat had 3 wounds that were treated topically wi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000481116.16998.55
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The objective of this multicenter study was to prospectively evaluate the healing outcomes of chronic diabetic foot ulcers (DFUs) treated with PriMatrix (TEI Biosciences, Boston, Massachusetts), a fetal bovine acellular dermal matrix. METHODS:Inclusion criteria required the subjects to have a chronic DFU tha...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ASW.0000451891.87020.69
更新日期:2014-08-01 00:00:00
abstract:GENERAL PURPOSE:The purpose of this learning activity is to provide information about the Healthy Foot Screen, a new tool for assessment of common foot abnormalities. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000530686.16243.d5
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to use glycerin to improve physical and wound adhesion properties of a wound dressing made of silk sericin and polyvinyl alcohol (PVA). DESIGN:Glycerin of a natural-derived plasticizer was used to modify the properties of silk sericin/PVA scaffolds. Various concentrations of glycerin were mi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000467304.77196.b9
更新日期:2015-08-01 00:00:00
abstract::Apligraf (Graftskin) is a bilayered, living human skin construct that is indicated for use with standard therapeutic compression for the treatment of noninfected partial- and full-thickness skin ulcers due to venous insufficiency of greater than 1-month duration that have not adequately responded to conventional ulcer...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::The reverse sural adipofascial flap (RSAF) is used to reconstruct challenging wounds of the foot and ankle. It offers several advantages over the traditional reverse sural flap, including less venous congestion. To complete the reconstruction, split-thickness skin grafting (STSG) may be done immediately or in a delaye...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000527290.81581.af
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To construct and validate an assessment instrument to evaluate the feet of people with diabetes mellitus in Brazil. METHODS:Methodological research developed in three stages: construction of the Assessment Instrument for the Feet of People with Diabetes Mellitus, validation of face and content validity, and ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000658588.28614.96
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To provide the practitioner with current information on the most common nail disorders. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in wound care and related disorders. OBJECTIVES:After reading this article and taking this test, the reader should b...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000276409.53632.42
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Lucilia sericata maggots are applied to chronic wounds to aid healing when conventional treatments have failed. After their application into a necrotic wound, they potentially influence wound healing with a combination of specific proteinases that are involved in the remodeling of extracellular matrix. These...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000461260.03630.a0
更新日期:2015-05-01 00:00:00
abstract::Thromboangiitis obliterans, or Buerger disease, is a rare nonatherosclerotic segmental inflammatory vasculitis that generally affects young tobacco smokers. Although no surgical treatment is available, the most effective way to halt the disease's progress is smoking cessation. In this case report, a 29-year-old smoker...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000604192.77577.6f
更新日期:2019-12-01 00:00:00