Abstract:
BACKGROUND:Lucilia sericata maggots are applied to chronic wounds to aid healing when conventional treatments have failed. After their application into a necrotic wound, they potentially influence wound healing with a combination of specific proteinases that are involved in the remodeling of extracellular matrix. These proteases cause changes in fibroblast adhesion and spread upon extracellular matrix protein surfaces, affecting integrity of the protein surfaces-especially fibronectin-while maintaining cell viability. OBJECTIVE:This study focused on in vitro monitoring of the effect of homogenate substances prepared from maggot salivary gland of L sericata on the ultrastructure of human neonatal fibroblasts. METHODS:Collagen/hyaluronan membrane was used as the synthetic substitute of extracellular matrix. The cultured human neonatal fibroblasts B-HNF-1 were seeded on the surface of the collagen/hyaluronan membrane and cultured with maggot salivary gland extract (SGE) at a concentration of 2.4 glands/1 mL. RESULTS:The authors observed increased cell metabolism and protein production (euchromatic nucleus, voluminous nuclear membrane, large reticular nuclei, distended and filled cisterns of rough endoplasmic reticulum, Golgi apparatus with saccules, and vesicles packed with fine fibrillar material) after incubating the cells in culture medium with SGE. CONCLUSION:The authors believe that increased cell metabolism and protein production corresponded with formation of microfibrillar net used for migration of fibroblasts in culture, but mainly for proper production of extracellular matrix. The authors suggest that their results may help explain the effect of SGE on wound healing and support implementation of maggot therapy into human medicine.
journal_name
Adv Skin Wound Carejournal_title
Advances in skin & wound careauthors
Polakovičova S,Polák Š,Kuniaková M,Čambal M,Čaplovičová M,Kozánek M,Danišovič L,Kopáni Mdoi
10.1097/01.ASW.0000461260.03630.a0subject
Has Abstractpub_date
2015-05-01 00:00:00pages
221-6issue
5eissn
1527-7941issn
1538-8654pii
00129334-201505000-00008journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:To compare the healing rate of forefoot ulcers in patients with diabetes treated using a total contact cast with those treated using alternative off-loading methods. DESIGN Retrospective analysis of healing rates of forefoot ulcers. SETTING:Louisiana State University Health Sciences Center Diabetes Foot Prog...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/00129334-200209000-00006
更新日期:2002-09-01 00:00:00
abstract:PURPOSE:To provide information about initiating interdisciplinary research related to microbiomes and their role in human immunity, disease, and metabolic processes. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES:After parti...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000489561.52393.0e
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Genital trauma during vaginal delivery may result from episiotomy, spontaneous perineal tears (perineum, vagina), or both. In 2012, this study aimed to investigate the effect of warm compress bistage intervention on the rate of episiotomy, perineal trauma, and postpartum pain intensity in the primiparous wom...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000476073.96442.91
更新日期:2016-02-01 00:00:00
abstract::Wound care professionals should carefully inspect and audit their coding and billing practices in light of (1) the OIG's 2014 Semiannual Report to Congress and (2) the 2015 OIG Work Plan.You can read the details of both documents by following the Internet links provided earlier in this article. Conducting those self-a...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000459891.21303.0f
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To review the etiology, anatomy, pathophysiology, differential diagnosis, and treatment of compartment syndrome. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in wound care. OBJECTIVES:After reading this article and taking this test, the reader shoul...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000294758.82178.45
更新日期:2007-10-01 00:00:00
abstract:GENERAL PURPOSE:To present a systematic review of the literature assessing the efficacy of monitoring devices for reducing the risk of developing pressure injuries. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.ASW.0000504579.83707.f6
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods. OBJECTIVE:To compare NCS with vacuum-assisted clos...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000547411.16017.58
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To provide the practitioner with current information on the most common nail disorders. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in wound care and related disorders. OBJECTIVES:After reading this article and taking this test, the reader should b...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000276409.53632.42
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to determine if the use of locally implanted, synthetic calcium sulfate tablets, impregnated with antibiotics, can heal lower-extremity osteomyelitis, without the use of oral and/or intravenous antibiotics or wound complications associated with similarly used mined or refined ca...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000407647.12832.6c
更新日期:2011-11-01 00:00:00
abstract:GENERAL PURPOSE:To increase health care professionals' awareness and perceptions of the skin as one of the largest body organs with multidimensional aspects and significant implications for interprofessional collaboration in whole-person care. TARGET AUDIENCE:This continuing education activity is intended for physicia...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000557830.01516.6b
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The goal of the present study was to evaluate the effects of hydroalcoholic extract-based carboxy methyl cellulose (CMC) gel of Punica granatum peel (PCMC) and CMC on healing of full-thickness skin wounds. MATERIALS AND METHODS:Forty-two rats were studied. Each rat had 3 wounds that were treated topically wi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000481116.16998.55
更新日期:2016-05-01 00:00:00
abstract:GENERAL PURPOSE:To review what is known about pediatric pressure injuries (PIs) and the specific factors that make neonates and children vulnerable. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound ca...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000577124.58253.66
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To conduct a cost-of-illness study of pressure ulcers in the Netherlands for different care settings, including home care, nursing homes, general hospitals, and university hospitals. DESIGN:A cost-of-illness study was conducted based on prevalence figures and expert opinion. A differential cost study approac...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/00129334-200203000-00008
更新日期:2002-03-01 00:00:00
abstract::Thromboangiitis obliterans, or Buerger disease, is a rare nonatherosclerotic segmental inflammatory vasculitis that generally affects young tobacco smokers. Although no surgical treatment is available, the most effective way to halt the disease's progress is smoking cessation. In this case report, a 29-year-old smoker...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000604192.77577.6f
更新日期:2019-12-01 00:00:00
abstract::Wound care professionals should consider all this attention to the key word documentation as your 2015 "heads-up." You should conduct a self-audit and request an external audit of your own documentation against all the regulations, LCDs, Policy Articles, newsletters, and educational programs that CMS and your MACs are...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000459113.03360.09
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study was to evaluate whether any of the Braden subscales were more strongly related to pressure ulcer occurrence than the Braden total score in obese and nonobese hospitalized patients. The authors investigated whether defining high risk for the total Braden score of 16 or less was associated with...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000437641.22278.67
更新日期:2014-01-01 00:00:00
abstract::Primary and metastatic malignancies may occasionally mimic or coexist with cutaneous fungal infections. The authors report 3 cases of cancers that were initially presumed to be cutaneous fungal infections. Dermatologists should maintain a low threshold for skin biopsy in patients with persistent or refractory fungal i...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000446864.26807.43
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To describe venous ulcer care and wound care practices in Gauteng, a province of South Africa, according to the Donabedian structure-process-outcome quality improvement model. METHODS:Forty-eight facilities were selected randomly from public and private wound care practices in Gauteng. Structured interviews ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000617848.46377.ae
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Infected or contaminated wound sites have historically been managed with incision and drainage. Here, the authors review their experience with skin closure over vessel loops and assess the results of this technique in a variety of clinical situations, hypothesizing that minimally invasive drainage strategies ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000694132.20581.ef
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To evaluate performance of a new silicone tape among clinicians caring for patients with fragile skin. DESIGN:An international, multisite, 2-week-use evaluation. PARTICIPANTS AND SETTINGS:Caregivers (n = 217) from acute care hospitals in the United States, United Kingdom, and France who regularly use tapes ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ASW.0000444646.43044.df
更新日期:2014-04-01 00:00:00
abstract::Apligraf (Graftskin) is a bilayered, living human skin construct that is indicated for use with standard therapeutic compression for the treatment of noninfected partial- and full-thickness skin ulcers due to venous insufficiency of greater than 1-month duration that have not adequately responded to conventional ulcer...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To examine the effect of arginine supplementation on wound healing, as measured by wound size and healing rate, in older adults in acute and long-term care (LTC) settings. DATA SOURCES:PubMed, CINAHL Plus, Google Scholar, and OpenGrey databases. STUDY SELECTION:Randomized clinical trials and clinical studie...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000579700.20404.56
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:To provide physicians and nurses with an overview of diabetic foot assessment. TARGET AUDIENCE:This continuing-education activity is intended for physicians and nurses with an interest in learning about proper diabetic foot assessment. OBJECTIVES:After reading the article and taking the test, the participant ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/00129334-200303000-00007
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:The objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment. DESIGN:Retrospective. SETTING:Plastic surgery office-based outpatient setting in New York City. PATIENTS:Forty patients with 44 keloid scars requiring surgical excision....
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000482993.64811.74
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To assess the incidence of and risk factors for pressure ulcers among patients with advanced human immunodeficiency virus type 1 (HIV-1) infection. DESIGN:Multicenter trial that included 1258 consecutive patients infected with HIV-1 who had 1815 admissions to 16 acute care infectious disease units in Italy. ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/00129334-200406000-00011
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of a pressure injury prevention algorithm on pressure injury prevention. DESIGN, SETTING, AND PARTICIPANTS:This intervention study was conducted in the anesthesiology and reanimation ICU (ARICU) of a university hospital. The study included two sample groups (nurses and patients). All p...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000553597.18658.6b
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess and compare the efficacy of high-voltage electrical stimulation (HVES) with ultrasound (US) in treating Stage II through Stage IV pressure ulcers (PrUs)* of hospitalized patients. DESIGN:This study was designed as a prospective, controlled trial in which patients were rand...
journal_title:Advances in skin & wound care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.ASW.0000526606.72489.99
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:The objective of this multicenter study was to prospectively evaluate the healing outcomes of chronic diabetic foot ulcers (DFUs) treated with PriMatrix (TEI Biosciences, Boston, Massachusetts), a fetal bovine acellular dermal matrix. METHODS:Inclusion criteria required the subjects to have a chronic DFU tha...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ASW.0000451891.87020.69
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. METHODS:A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical tr...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000462328.60670.c3
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To enhance the learner's competence with knowledge of the results of research examining suspected deep tissue injury profiles. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES:After participating in this educational ac...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000443267.25288.87
更新日期:2014-03-01 00:00:00