Abstract:
BACKGROUND:Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of dementia (BPSD). METHODS:This was a prospective cohort study of older adults with DSD admitted to a specialized delirium unit (December 2010-August 2012). We collected data on demographics, comorbidities, illness severity, delirium precipitants, and cognitive and functional scores. Delirium severity was assessed using Delirium Rating Scale Revised-98 (DRS-R-98) and Cognitive Assessment Method severity score (CAM-sev). Patients were categorized as DSD-BPSD+ and DSD-BPSD- based on elicited behavioral and psychological disturbances. RESULTS:We recruited 174 patients with DSD (84.4 +/-7.4 years) with 37 (21.3%) having BPSD. At presentation, delirium severity and symptom frequency on DRS-R98 were similar, but DSD-BPSD+ more often required only a single precipitant (40.5% vs. 21.9%, p = 0.07), and had significantly longer delirium duration (median days: 7 vs. 5, p < 0.01). At delirium resolution, DSD-BPSD+ exhibited significant improvement in sleep-wake disturbances (89.2% vs. 54.1%, p < 0.01), affect lability (81.1% vs. 56.8%, p = 0.05), and motor agitation (73% vs. 40.5%, p < 0.01), while all non-cognitive symptoms except motor retardation were improved in DSD-BPSD-. Pharmacological restraint was more prevalent (62.2% vs. 40.1%, p = 0.03), and at higher doses (chlorpromazine equivalents 0.95 +/-1.8 vs. 0.40 +/-1.2, p < 0.01) in DSD-BPSD+. CONCLUSIONS:BPSD may increase vulnerability of dementia patients to delirium, with subsequent slower delirium recovery. Aggravation of sleep disturbance, labile affect, and motor agitation should raise suspicion for delirium among these patients.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Abengaña J,Chong MS,Tay Ldoi
10.1017/S1041610216001836subject
Has Abstractpub_date
2017-03-01 00:00:00pages
485-495issue
3eissn
1041-6102issn
1741-203Xpii
S1041610216001836journal_volume
29pub_type
杂志文章abstract:BACKGROUND:Music can be therapeutic to people with dementia; however, little is known about its effect on the family carers. This project aimed to (1) assess the effects of MP3 player use by a person with dementia on caregivers' mental health and wellbeing, including their self-care and health-promoting behavior and (2...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001999
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abstract:BACKGROUND:Official health organizations have established the dose of physical activity needed for preserving both physical and psychological health in old age. The objective of this study was to explore whether adherence to the recommended criterion of physical activity accounted for better psychological functioning i...
journal_title:International psychogeriatrics
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610298005249
更新日期:1998-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610219000358
更新日期:2020-04-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2011-03-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610207006564
更新日期:2008-04-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610297005036
更新日期:1997-01-01 00:00:00
abstract::One hundred and seven newly diagnosed, untreated patients with Parkinson's disease (PD) were divided into two groups according to their age at reported onset of symptoms. Of these, 79 patients were under age 70 (early-onset) and 28 patients were age 70 and over (late-onset). The group of 50 control subjects comprised ...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Alterations in iron metabolism have been suggested as potential pathological markers in patients with manifest depression. No data on the association between iron and depression exist from population-based studies, in which milder forms of depressive symptoms are much more common. The aim of this study was t...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610205002759
更新日期:2006-09-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001442
更新日期:2017-11-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210000700
更新日期:2011-02-01 00:00:00
abstract::Noncognitive or behavioral and psychological symptoms (BPSD) are common in vascular dementia. Many occur with the same frequency as in Alzheimer's disease, though depression, emotional lability, and apathy may be more common and psychosis less so. There is a particularly strong relationship between cerebrovascular dis...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610203009098
更新日期:2003-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:International psychogeriatrics
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更新日期:2013-05-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 历史文章,杂志文章,评审
doi:10.1017/S1041610211001864
更新日期:2012-02-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610205001481
更新日期:2005-06-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610217001818
更新日期:2017-11-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
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更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:There are difficulties in accurately defining patients with vascular dementia (VaD) and, therefore, little is known about the characteristics of this population. OBJECTIVE:To examine the population characteristics in patients with VaD enrolled in two randomized, double-blind, placebo-controlled, 24-week cli...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:International psychogeriatrics
pub_type: 杂志文章,多中心研究
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更新日期:2019-05-01 00:00:00
abstract::Epidemiologic survey data were used to examine relationships between alcohol use and abuse and the physical and mental health status of elderly public housing residents (weighted n = 865) and to determine the influence that drinking behavior had on mortality. Residents with a current alcohol disorder (4%) were more li...
journal_title:International psychogeriatrics
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00