A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression.

Abstract:

BACKGROUND:The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients. METHODS:Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods. RESULTS:No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex. CONCLUSIONS:Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.

journal_name

Int Psychogeriatr

authors

Khundakar A,Morris C,Oakley A,Thomas AJ

doi

10.1017/S1041610210000700

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

132-40

issue

1

eissn

1041-6102

issn

1741-203X

pii

S1041610210000700

journal_volume

23

pub_type

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