Abstract:
BACKGROUND:The orbitofrontal cortex has been implicated as a key component in depression by several imaging studies. This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients. METHODS:Post mortem tissue from 13 patients with major depression and 11 matched controls was obtained and analyzed using the optical disector and nucleator methods. RESULTS:No changes were found in glial cell, pyramidal or non-pyramidal neuron density, or in non-pyramidal and pyramidal neuron volume in the orbitofrontal cortex. CONCLUSIONS:Based on previous findings, this study suggests variability in morphological changes within the orbitofrontal cortex, as well as the prefrontal cortex as a whole.
journal_name
Int Psychogeriatrjournal_title
International psychogeriatricsauthors
Khundakar A,Morris C,Oakley A,Thomas AJdoi
10.1017/S1041610210000700subject
Has Abstractpub_date
2011-02-01 00:00:00pages
132-40issue
1eissn
1041-6102issn
1741-203Xpii
S1041610210000700journal_volume
23pub_type
杂志文章abstract:BACKGROUND:Since its development, the Qualidem has had items that were considered unsuited for people with very severe dementia. This study attempted to investigate the applicability of all Qualidem items in people with all stages of dementia severity. METHODS:Four data sets that contained Qualidem observations on peo...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217001405
更新日期:2017-09-04 00:00:00
abstract::Although individuals aged 65 and over accounted for 12% of the total population of Japan in 1990, suicides in this age group consisted of 29% of all suicides. The elderly population of Japan is expected to grow rapidly to 24% of the total population by the year 2020, and suicide prevention for the elderly is an urgent...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610295002006
更新日期:1995-07-01 00:00:00
abstract::ABSTRACTAssociations between high body mass index (BMI) and subsequent cognitive decline, reported in elderly averaging below age 75, become less consistent at older ages. We compared the associations of BMI with cognition in moderately old (ages 75-84, N = 154) and oldest-old (85+, N = 93) samples. BMI and cognition ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218001412
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Family involvement in long-term care (LTC) is important but it can prove challenging and result in conflict with staff if families do not feel connected to the LTC facility or if they believe that their contributions are undervalued. According to McMillan & Chavis (1986), sense of community (SOC) refers to a...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001524
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:This subanalysis of a large, double-blind, placebo-controlled trial examined the prevalence of behavioral symptoms in moderate to severe Alzheimer's disease (AD), and the effect of treatment with donepezil. METHODS:Two hundred ninety patients with moderate to severe AD (standardized Mini-Mental State Examina...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1017/s104161020200858x
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:The study aimed to evaluate the Cognitive Assessment Battery (CAB) in a specialist clinic setting in order to find out if it if it could be a supplement to the Mini-mental State Examination (MMSE) and distinguish between normal aging, mild cognitive impairment (MCI) and dementia, as well as MCI of different ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610210002334
更新日期:2011-09-01 00:00:00
abstract::The objectives of this randomized clinical trial were to investigate the impact of the discontinuation of long-term antipsychotics in residents with dementia in chronic care institutions and to identify clinical predictors of safe discontinuation. Subjects included 34 residents with dementia who were on antipsychotics...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s1041610202008396
更新日期:2002-06-01 00:00:00
abstract::Few would argue that achieving the age of 100 years is extraordinary, but what about the quality of life at this extreme age? Is it worth it to live to 100 and beyond? The study by Araújo, Ribero, Teixeira, and Paúl (2015) in three ways provided an answer to this question substantiating and complementing recent findin...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610215002021
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The Addenbrooke's Cognitive Examination (ACE) and its Revised version (ACE-R) are relatively new screening tools for cognitive impairment that may improve upon the well-known Mini-Mental State Examination (MMSE) and other brief batteries. We systematically reviewed diagnostic accuracy studies of ACE and ACE-...
journal_title:International psychogeriatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S1041610213002329
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:To investigate the presence of neuropsychiatric symptoms (NPS) and sub-syndromes in elderly community-dwelling Asians with varying severity of cognitive impairment. METHODS:Chinese and Malay participants (n = 613) from the Epidemiology of Dementia in Singapore (EDIS) Study aged ≥ 60 years underwent clinical...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610215000976
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Emotional distress associated with Parkinson's disease (PD) increases disease burden and decreases functioning. The literature supports the benefits of psychological interventions for amelioration of emotional distress in persons with PD. The objective of this study is to apply the Contextual Adult Lifespan ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216000569
更新日期:2016-10-01 00:00:00
abstract::ABSTRACTBackground:Psychological and social resources such as extraversion, optimism, social support, or social networks contribute to adaptation and to successful aging. Building on assumptions derived from successful aging and from the developmental adaptation models, this study aims to analyze the joint impact of d...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610218000388
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:There is suggestion that self-reported depressive syndromes can independently manifest in the general population as cognitive/affective or somatic/vegetative. The Beck Depression Inventory, 2nd edition (BDI-II), a self-report measure of depressive symptoms, has been shown to support this two-factor structure...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610212001676
更新日期:2013-03-01 00:00:00
abstract::Thirty-seven subjects, 15 with a clinical diagnosis of Alzheimer's disease and 22 normal controls, participated in a study of the accuracy of telephone screening in identifying potential dementia cases. The telephone protocol and scoring algorithm resulted in 100% sensitivity and 91% specificity. The findings suggest ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610295002171
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:We assessed the relationship between cognitive impairment (including mild cognitive impairment with no signs of dementia, and dementia) and risk for depression in old age (60 years and older). METHODS:MEDLINE, EMBASE and the Cochrane Library database were used to identify potential studies. All of the clini...
journal_title:International psychogeriatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S1041610210000049
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Common sense suggests and research indicates relationships between staff factors in residential dementia care and quality of life (QOL) for residents, with poor care increasing suffering. However, we do not have a coherent picture of which staff interventions have an impact on quality of care (QOC) or reside...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610216001083
更新日期:2016-12-01 00:00:00
abstract::The World Alzheimer Report 2016 estimated that 47 million people are living with dementia worldwide (Alzheimer's Disease International, 2016). In the inaugural World Health Organization Ministerial Conference on Global Action against Dementia, six of the top ten research priorities were focused on prevention, identifi...
journal_title:International psychogeriatrics
pub_type: 评论,杂志文章
doi:10.1017/S1041610218000042
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610217000746
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. METHODS:Translation and transcultural adaptation was performed according to st...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000379
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:This study aimed to assess the prevalence, incidence, and persistence of suicidal ideation (SI), and to investigate the psychosocial factors associated with these. METHODS:A total of 1,204 community dwelling elderly adults aged 65 years or older were evaluated at baseline, 909 (75%) of whom were followed tw...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213001634
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Olfactory dysfunction, impaired smell identification in particular, is known as a diagnostic and a marker of conversion in Alzheimer's disease (AD). We aimed to evaluate the associations of olfactory identification impairments with cognition, illness severity, and progression in AD patients. METHODS:Fifty-s...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610213000446
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to give an in-depth description of the impact of disclosure of the diagnosis of dementia on a patient and the patient's partner. METHODS:Grounded theory interview study. RESULTS:Analysis of the interviews revealed that disclosure had an impact on three key domains: awareness of dem...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/s1041610205001316
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:While the relationship of apolipoprotein E (APOE) to behavioral symptoms of dementia (BSD) has been studied in community-dwelling persons with AD, it has received limited attention within the nursing home (NH) population. The aim of this study was to examine the association between APOE genotype and BSD in N...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610209009235
更新日期:2009-08-01 00:00:00
abstract::I read with great interest the study of Petrazzuoli et al. (2017) on exploring dementia management attitudes in primary care. The authors made a laudable effort to evaluate this important issue, which certainly needs timely attention. The high response rate from 25 member countries of the European General Practice Res...
journal_title:International psychogeriatrics
pub_type: 评论,信件
doi:10.1017/S1041610217003003
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:The aim of the study was to determine the amount of trauma impact and significant post-traumatic stress symptoms, which can indicate a possible post-traumatic stress disorder (PTSD), in a sample of former German child soldiers of World War II. METHODS:103 participants were recruited through the press, then ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007035
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:People with Young Onset Dementia (YOD) have specific needs for care. These people eventually require institutional care, usually delivered by institutions designed for the elderly. The Dutch network of care organizations delivering specialized YOD care offers a unique opportunity to obtain more knowledge of ...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610214001859
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Older migrants with dementia and limited English language proficiency in residential care may have unmet needs for social interaction. This project compared verbal communication and prescribed psychiatric medication of Greek and Italian residents with dementia in ethno-specific and mainstream residential car...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610211002134
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:There are difficulties in accurately defining patients with vascular dementia (VaD) and, therefore, little is known about the characteristics of this population. OBJECTIVE:To examine the population characteristics in patients with VaD enrolled in two randomized, double-blind, placebo-controlled, 24-week cli...
journal_title:International psychogeriatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/S1041610203009190
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The aim of this study is to investigate the diagnostic value of perfusion 99mTc-exametazime single photon emission computed tomography (SPECT) in the diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) in comparison with dopaminergic 123I-2beta-carbomethoxy-3beta-(4-iodophenyl)-n-(3-flu...
journal_title:International psychogeriatrics
pub_type: 杂志文章
doi:10.1017/S1041610208007709
更新日期:2008-12-01 00:00:00
abstract::Over the past five to ten years, neuroimaging capability for neurodegenerative diseases has made remarkable progress. However, debate remains as to the true clinical utility of these advanced and costly investigations. Not only is the place of these tests in diagnostic algorithms unclear, but the access to them varies...
journal_title:International psychogeriatrics
pub_type: 杂志文章,评审
doi:10.1017/S1041610211000901
更新日期:2011-09-01 00:00:00