Abstract:
:The vacuoles occurring in rat hepatocytes after intraportal injection of retinol (33 or 67 micrograms) were examined immunohistochemically using respective antibodies against rat albumin, human retinol-binding protein, human ceruloplasmin, human alpha 1-antitrypsin, human transferrin, and human prealbumin as representative plasma proteins. The occurrence of the vacuoles reached a numerical maximum 30 min after injection of 67 micrograms retinol, followed by a temporal decrease. Hepatocytes from control rats, which had been intraportally injected with either blood plasma diluted to 2/3 concentration or with retinol palmitate solvent (castor oil) dissolved in blood plasma, showed immunoreactive fine granules without the occurrence of vacuoles in the cytoplasm. Identical vacuoles in serial sections appeared immunohistochemically either immunoreactive or non-immunoreactive for all the antibodies used, with rare exceptions. The occurrence of several rare exceptions suggested that 2 kinds of vacuoles might be formed in different cytoplasmic compartments. A zonal distribution of vacuoles was apparent in the hepatic laminae (or acini) within the liver lobules. The vacuoles were predominantly distributed in zone 2, and to a lesser extent in zone 3 and zone 1 in that order.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Kudo Sdoi
10.1007/BF00261829subject
Has Abstractpub_date
1989-08-01 00:00:00pages
263-8issue
2eissn
0302-766Xissn
1432-0878journal_volume
257pub_type
杂志文章abstract::Intercellular communication between smooth muscle cells is crucial for contractile behaviour in normal and pathologically altered urinary bladder. Since the study of coupling is difficult in situ, we established cell cultures of bladder smooth muscle cells to analyse coupling mechanisms. Microinjection of Lucifer yell...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0559-2
更新日期:2002-08-01 00:00:00
abstract::In fresh-water turtles, the bridge connecting the proximal and caudal stumps of transected spinal cords consists of regenerating axons running through a glial cellular matrix. To understand the process leading to the generation of the scaffold bridging the lesion, we analyzed the mitotic activity triggered by spinal i...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1173-y
更新日期:2011-06-01 00:00:00
abstract::Neuromuscular terminals of a single motoneuron to four muscles (CPV7a, GM5a, CV2, and CV3) in the stomach of the blue crab Callinectes sapidus showed structural evidence for the exocytotic release of dense-core vesicles exclusively at synapses. The primary evidence was the appearance of dense cores in the synaptic cle...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050897
更新日期:1997-09-01 00:00:00
abstract::Bone resorption by mononucleated cells was studied in the acellular bone of a teleost fish (Oreochromis niloticus) by histological and enzyme histochemical observations and by transmission electron microscopy. Bone resorbing cells (osteoclasts) were identified by their location at the sites of bone resorption, their f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050782
更新日期:1997-02-01 00:00:00
abstract::Nervous elements in the periodontal ligament and dental pulp of rat incisors were investigated by means of immunohistochemistry for neurofilament protein (NFP) and glia-specific S-100 protein. The periodontal ligament in the incisors was densely innervated by NFP-immunoreactive nerve fibers; the distribution of the ne...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215442
更新日期:1988-01-01 00:00:00
abstract::Recent studies demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in primary sensory neurons (PSNs). The present study was undertaken to reveal the target-specific expression of the InsR and its co-localizati...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2868-0
更新日期:2018-11-01 00:00:00
abstract::The use of porcine hepatocytes in xenotransplantation, bioartificial liver support or pharmacological approaches demands serum-free cryopreservation protocols yielding high quality, viable, functional hepatocytes. Here, primary porcine hepatocytes were frozen without serum in liquid nitrogen by the use of a computer-a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-0894-6
更新日期:2004-07-01 00:00:00
abstract::Effects of steroids on the accumulation of glycoprotein gonadotropin (GTH) in pituitaries of juvenile trout were investigated by means of scanning cytophotometry applied to immunocytochemical preparations, and with the use of a radioimmunoassay. Effects on other aspects of GTH-cell activity were analyzed by measuring ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00226962
更新日期:1984-01-01 00:00:00
abstract::The mechanism of cell death which occurs during Chagas' cardiopathy is disputed. To address this issue we analyzed the molecular pathways implicated in the death of cardiomyocytes during T. cruzi invasion and found that they undergo apoptosis during both in vitro and in vivo infections. However, the death rates and on...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0782-5
更新日期:2003-11-01 00:00:00
abstract::Examination of pituitaries from young and adult turtles representing four families, reveals that in addition to the abundant juxtaneural pars tuberalis (juxPT) found in this class of reptiles, there is generally a substantial amount of pars tuberalis (PT) tissue closely associated with the pars distalis (PD). The PT f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218290
更新日期:1982-01-01 00:00:00
abstract::An indirect immunofluorescence study of the frozen sections of the spleen of an anuran amphibian, Xenopus laevis, showed that lymphocytes bearing a small amount of immunoglobulin (Ig) were localized mostly in the white pulp of non-immunized toads. There were fewer fluorescent cells in the red pulp. In the toads hyperi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218363
更新日期:1982-01-01 00:00:00
abstract::The purpose of this study was to determine the cellular distribution and degradation in rat liver following intravenous injection of superparamagnetic iron oxide nanoparticles used for magnetic resonance imaging (NC100150 Injection). Relaxometric and spectrophotometric methods were used to determine the concentration ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-0884-8
更新日期:2004-06-01 00:00:00
abstract::The startle is a relatively simple ubiquitous reflex. Interestingly, it has a "non-zero baseline", i.e., its magnitude can be reduced or enhanced. We reflect here on the translational value of prepulse inhibition and fear-related potentiation as endophenotypes that can be used for the investigation of complex psychiat...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-013-1599-5
更新日期:2013-10-01 00:00:00
abstract::Immunoreactivity to the polypeptide designated "7B2" recently isolated from human and porcine pituitary glands, appears to be consistently confined to neuroendocrine and endocrine cells in various tissues. In rat gut, immunoreactive 7B2 was found in endocrine-paracrine cells. Highly labeled cells were found in the ant...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217343
更新日期:1987-09-01 00:00:00
abstract::The lobula descending neuron (LDN) of dipterous insects is a unique nerve cell (one on each side of the brain) that projects directly from the lobula complex of the optic lobes to neuropil in thoracic ganglia. In the supraoesophageal ganglia the LDN has two prominent groups of branches of which at least one is dendrit...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218365
更新日期:1982-01-01 00:00:00
abstract::The treatment of isolated protoplasmic strands of Physarum polycephalum with 2.5% ethanol in a physiological salt solution under isometric conditions induces the formation of a large amount of mostly longitudinally organized actomyosin fibrils in the endoplasmic channel, a region normally free of actomyosin fibrils. T...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218017
更新日期:1985-01-01 00:00:00
abstract::Rat thymic phagocytic cells were characterized in vitro using various light- and electron-microscopical techniques. Thymic cell suspensions were mechanically prepared and enriched for non-lymphoid cells, which were predominantly phagocytic and of three types. Type I showed acid phosphatase (APh) activity in small gran...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222183
更新日期:1983-01-01 00:00:00
abstract::Parachlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase which depletes brain serotonin in higher vertebrates, was injected into freshwater eels. After 4 or 6 injections (200 mg/kg/day) or 10 injections (100 and 140 mg/kg/day), the animals are paler, with a low melanophore index. In the pituitary gland, ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00223217
更新日期:1978-07-13 00:00:00
abstract::The livers of Xenopus laevis, grouped by chronological age (0.5, 2 and 3 yrs), were studied electron microscopically. Ultrastructurally most of the melanin granules in the mature female liver showed an internal structure similar to the melanin granules of the oocytes. The hepatic melanin granules of immature females a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220293
更新日期:1977-12-19 00:00:00
abstract::The papillary muscle of the cat heart's right ventricle has not been studied previously with quantitative ultrastructural techniques despite its wide use for functional studies. This tissue was perfusion-fixed, processed for electron microscopy, and morphometric techniques were used to assess the ultrastructural chara...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216200
更新日期:1983-01-01 00:00:00
abstract::Maturing erythroblasts and erythrocytes were studied in chickens and adult hens to provide more information on the presence and frequency of various nucleolar types in these cells. Nucleoli were present at all stages of erythroblastic and erythrocytic development except in the case of a few reticulocytes and the matur...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209211
更新日期:1975-09-17 00:00:00
abstract::1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] induces osteoclast formation via induction of receptor activator of NF-κB ligand (RANKL, also called TNF-related activation-induced cytokine: TRANCE) in osteoblasts. In cocultures of mouse bone marrow cells and osteoblasts, 1,25(OH)(2)D(3) induced osteoclast formation in a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-1052-y
更新日期:2010-11-01 00:00:00
abstract::Orexins (OxA and OxB) and their receptors (Ox1R and Ox2R), originally detected in the hypothalamus, have also been localized in multiple cerebral areas and peripheral organs. Thus, in addition to their central function in the regulation of food intake, arterial blood pressure, heart rate, sleep/wake cycle, sexual beha...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1394-8
更新日期:2012-06-01 00:00:00
abstract::Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with highly potent neurotrophic and neuroprotective effects. PACAP and its receptors occur in the retina and PACAP has been applied in animal models of metabolic retinal disorders to reduce structural and functional damage. Furthermore, PACAP...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1349-0
更新日期:2012-04-01 00:00:00
abstract::The antigen detected by the rat anti-mouse monoclonal antibody (m Ab), anti-BSP-3, has been initially described as a brain cell-surface protein. Evidence is presented that this m Ab recognizes mouse (Na+ + K+)-ATPase (ATP phosphohydrolase, E.C.3.6.1.3). The antigen, purified from mouse brain by means of affinity chrom...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218655
更新日期:1983-01-01 00:00:00
abstract::The spleen of the oriental fire-bellied toad, Bombina orientalis, consists of well-developed white pulp, separated from the lymphocytic marginal zone by the connective tissue boundary layer. Injection of peroxidase-conjugated rabbit anti-peroxidase revealed that these immune complexes were localized on the surface of ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00297553
更新日期:1993-01-01 00:00:00
abstract::Based on its proven anabolic effects on bone in osteoporosis patients, recombinant parathyroid hormone (PTH(1-34)) has been evaluated as a potential therapy for skeletal repair. In animals, the effect of PTH(1-34) has been investigated in various skeletal repair models such as fractures, allografting, spinal arthrodes...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-011-1188-4
更新日期:2012-03-01 00:00:00
abstract::The subcommissural organ secretes N-linked complex-type glycoproteins into the cerebrospinal fluid. These glycoproteins condense to form Reissner's fiber (RF), which extends along the fourth ventricle and central canal of the spinal cord. A set of three monoclonal antibodies (Mabs 3E6, 3B1, and 2A5) has been obtained ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050672
更新日期:1996-10-01 00:00:00
abstract::The ultrastructure of the isolated glycerinated penis retractor muscle (PRM) of Helix pomatia was investigated. The diameter distributions of thick myofilaments from birbre cross sections in the relaxed, phasic contracted, tonic contracted, and in the catch state.s show that a characteristic filament spectrum is forme...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221808
更新日期:1975-01-01 00:00:00
abstract::Immediately following the discovery of tryptophan hydroxylase in Drosophila, we demonstrated the presence of tryptophan hydroxylase in the brain of the beetle Harmonia axyridis (Coleoptera: Coccinellidae). However, whether tryptophan hydroxylase is present in the brains of other insects is still a matter of discussion...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0596-6
更新日期:2008-06-01 00:00:00