Abstract:
:RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Weldon C,Behm-Ansmant I,Hurley LH,Burley GA,Branlant C,Eperon IC,Dominguez Cdoi
10.1038/nchembio.2228subject
Has Abstractpub_date
2017-01-01 00:00:00pages
18-20issue
1eissn
1552-4450issn
1552-4469pii
nchembio.2228journal_volume
13pub_type
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