Abstract:
:In the setting of recent exciting clinical results and numerous ongoing trials, Gainor and colleagues explored mechanisms of acquired resistance to first- and second-generation ALK inhibitors in ALK-rearranged non-small cell lung cancer and found that an increased frequency and distinct spectrums of resistance mutations emerged with the more potent second-generation inhibitors. Their findings have important and immediate clinical implications as the resistance mutations detected impart differential sensitivities to available ALK inhibitors, thereby highlighting the need for sequential biopsies with molecular testing to determine the most effective treatment strategy upon disease progression. Cancer Discov; 6(10); 1084-6. ©2016 AACRSee related article by Gainor et al., p. 1118.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Qiao H,Lovly CMdoi
10.1158/2159-8290.CD-16-0910subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1084-1086issue
10eissn
2159-8274issn
2159-8290pii
6/10/1084journal_volume
6pub_type
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