Abstract:
:Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder. Evidence suggests that ASD patients have abnormalities in information processing. Event-related potential (ERP) technique can directly record brain neural activity in real time. P300 is a positive ERP component which can measure the neuroelectrophysiological characteristics of human beings and has the potential to discover the pathological mechanism of ASD. However, P300 studies on ASD patients are incongruent and the disparities may be caused by several factors. By searching PubMed, Embase and Cochrane Library databases, a meta-analysis of P300 component difference between ASD group and typically developed (TD) control group was conducted. Results of amplitude and latency of P3b and P3a from included studies were synthesized. Random effect model was chosen and standardized mean difference (SMD) was calculated. Subgroup analysis was used to identify the source of heterogeneity and to test the effect of different experiment factors. A total of 407 ASD patients and 457 TD controls from 32 studies were included in this analysis. Reduced amplitude of P3b was found in ASD group (SMD = -0.505, 95 % CI -0.873, -0.138) compared with TD group, but no difference of P3b latency, P3a amplitude, or P3a latency was found between groups. Subgroup analysis showed that oddball paradigm elicited attenuated P3b amplitude in Pz electrode among ASD subjects. This meta-analysis suggests ASD patients have abnormalities in P300 component, which may represent for deficits in cognition, attention orientation and working memory processing, particularly in the decision-making processing condition.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Cui T,Wang PP,Liu S,Zhang Xdoi
10.1007/s00787-016-0880-zsubject
Has Abstractpub_date
2017-02-01 00:00:00pages
177-190issue
2eissn
1018-8827issn
1435-165Xpii
10.1007/s00787-016-0880-zjournal_volume
26pub_type
杂志文章,meta分析abstract::The network approach suggests that psychopathology arises from complex associations between symptoms and may offer insight into the mechanisms that underpin psychiatric comorbidities. The transition from childhood to adolescence is a key period in the development of psychopathology, yet has rarely been considered from...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-018-1128-x
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:This study aims to examine a) the prevalence of psychosocial problems and b) the association between parent-reported problems and the identification by doctors and nurses (child health professionals, CHP) working in preventive child health care, among immigrant and non-immigrant children. METHODS:CHPs exami...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-005-0454-y
更新日期:2005-05-01 00:00:00
abstract::Academic impairment in individuals with attention-deficit/hyperactivity disorder (ADHD) is in part due to reduced motivation for academic tasks, which is likely to vary as a function of task characteristics. The current study employed a new questionnaire-the Child and Adolescent Motivational Profile (CHAMP)-to examine...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01494-8
更新日期:2020-03-10 00:00:00
abstract::In the adult population, psychiatric disorders are associated with somatic illness. Explanatory life style factors have been found, but also a failure to recognize somatic illness in this group. Another factor is side effects from long-term use of antipsychotic drugs. Given the psychiatric-somatic comorbidity in the a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01313-9
更新日期:2019-11-01 00:00:00
abstract::Coping, general well-being and self-esteem play an important role during the process of adaptation to turning points in life-course. This study aimed to investigate the effect of coping on both the development of general well-being and self-esteem of adolescents with severe psychiatric problems in secure residential c...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0629-5
更新日期:2015-07-01 00:00:00
abstract::Rising global rates of pathological Internet use (PIU) and related psychological impairments have gained considerable attention in recent years. In an effort to acquire evidence-based knowledge of this relationship, the main objective of this study was to investigate the association between PIU, psychopathology and se...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0562-7
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:To develop an evidence base for using antipsychotic medications for schizophrenia in children and adolescents. METHOD:Data sources were identified in PsychINFO (1872-2003), MEDLINE (1966-2003), and articles in reference lists. Study selection criteria: (1) treatment with antipsychotics; (2) ages were betwee...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00787-005-0515-2
更新日期:2006-03-01 00:00:00
abstract::Seven children and young adults with definite signs of Asperger syndrome were administered a battery of tests designed to test: intelligence; left and right cerebral hemisphere functioning; ability to discriminate eye gaze; and social judgment. The subjects revealed a non significant tendency to have a higher verbal I...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF01978114
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:Difficulties imitating gestures have been found in several studies in children and adolescents with Autism Spectrum Disorders (ASD). It has been hypothesized that imitation abilities might be precursors of language abilities in young children with autism. No study on imitation and language abilities in ado...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-006-0533-8
更新日期:2006-08-01 00:00:00
abstract::Non-suicidal self-injury (NSSI) is a considerable health problem among adolescents. Affect regulation by means of self-injury may promote the maintenance of NSSI. However, existing findings have limited ecological validity. The present study aimed to assess emotional and interpersonal states preceding and following in...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01626-0
更新日期:2020-08-29 00:00:00
abstract::Children with autism-spectrum disorders (ASD) often fail laboratory false-belief tests of theory of mind (ToM). Yet how this impacts on their everyday social behavior is less clear, partly owing to uncertainty over which specific everyday conversational and social skills require ToM understanding. A new caregiver-repo...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-008-0711-y
更新日期:2009-02-01 00:00:00
abstract::Somatic disorders occur more often in adult psychiatric patients than in the general adult population. However, in child and adolescent psychiatry this association is unclear, mainly due to a lack of integration of existing data. To address this issue, we here present a systematic review on medical comorbidity in the ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-017-1020-0
更新日期:2017-09-01 00:00:00
abstract::Gender and sexually diverse adolescents have been reported to be at an elevated risk for suicidal thoughts and behaviors. For transgender adolescents, there has been variation in source of ascertainment and how suicidality was measured, including the time-frame (e.g., past 6 months, lifetime). In studies of clinic-ref...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01663-9
更新日期:2020-11-09 00:00:00
abstract::The Revised Behaviour Summarized Evaluation Scale (BSE-R) was developed for the objective evaluation of autistic behaviours in order to facilitate the recording of the evolution of developmentally disabled children. Among its 29 items, 13 items that precisely describe the degree of autistic behaviours were extracted b...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF01980489
更新日期:1995-10-01 00:00:00
abstract::The importance of paying attention to scale levels is emphasized and it is pointed out that Steven's hierarchy of ratio, interval, ordinal, and nominal scales is too narrow; other important scale properties have to be considered. For instance, sometimes a carefully constructed variable on a nominal scale contains more...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00538540
更新日期:1996-01-01 00:00:00
abstract::The primary purpose of this study was to investigate autistic children's scripts for social routines. Scripts specify familiar events in terms of who does what, when, to whom, and why. Scripts are verbalizations of mental event representations, containing and organizing generalized knowledge of how the world works. Sc...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050082
更新日期:1999-03-01 00:00:00
abstract::This project describes the dissemination of an evidence-based parenting skills intervention by training social and health workers with little or no mental health background so that they themselves train mothers of children with behavioral problems in impoverished communities in a developing country. The Strengths and ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-010-0099-3
更新日期:2010-08-01 00:00:00
abstract::Evidence regarding the psychiatric morbidity of children born after Assisted Reproductive Techniques (ART) is inconsistent and limited. While normal mental well-being for ART children is usually reported, concerns are still being raised. Previous studies examine only some psychiatric disorders, but not all of them, ig...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01433-2
更新日期:2020-08-01 00:00:00
abstract::Neurofeedback (NF) could help to improve attentional and self-management capabilities in children with attention-deficit/hyperactivity disorder (ADHD). In a randomised controlled trial, NF training was found to be superior to a computerised attention skills training (AST) (Gevensleben et al. in J Child Psychol Psychia...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-010-0109-5
更新日期:2010-09-01 00:00:00
abstract::Twenty-two Hungarian families with Rett syndrome girls were genealogically examined. None of our 23 probands was born to first-cousin couples, but we established increased number of consanguineous marriages among the ancestors of the patients. Observing the places where the Rett families originate from, we found a pre...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:In Tourette syndrome (TS) as a neurodevelopmental disorder not only the tics but also the comorbid conditions change with increasing age. ADHD is highly comorbid with TS and usually impairs psychosocial functioning more than the tics. Its impact on further comorbidity during development is important for clin...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-1004-6
更新日期:2007-06-01 00:00:00
abstract::This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for indiv...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050005
更新日期:2000-06-01 00:00:00
abstract::To explore behavioral differences as possible cultural factors in presentation of psychiatric comorbidity in two clinically referred, consecutively ascertained samples of youth with Tourette's disorder (TD) from New York and Buenos Aires. Subjects were evaluated between 2002 and 2010 at the Tics and Tourette's Clinica...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0406-x
更新日期:2013-11-01 00:00:00
abstract::Parents may develop symptoms of distress and dysfunctional cognitions in response to their child's exposure to traumatic events. Additionally, they may also be affected by their own traumatic experiences. This study investigated the frequency of traumatic experiences and of symptoms of posttraumatic stress and depress...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0821-x
更新日期:2016-09-01 00:00:00
abstract::A Dutch translation of the Strengths and Difficulties Questionnaire (SDQ) was made. In the first wave of data collection, self-report data of 11- to 16-yearolds (N = 970) were collected on the SDQ and other measures of psychopathology. In the second wave of data collection, extended versions of the SDQ were completed ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-003-0341-3
更新日期:2003-12-01 00:00:00
abstract::The aim of the study was to investigate the potential association of epilepsy and EEG abnormalities with autistic regression and mental retardation. We examined a group of 77 autistic children (61 boys, 16 girls) with an average age of 9.1 +/- 5.3 years. Clinical interview, neurological examination focused on the eval...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-004-0353-7
更新日期:2004-08-01 00:00:00
abstract::Socioeconomic disadvantage has been linked to mental health difficulties in children and adolescents, although many children appear to do well despite exposure to financial adversity in childhood. Our study looked at the effects of family financial difficulty on children's mental health outcomes (n = 636) at 4-5 years...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1007/s00787-019-01348-y
更新日期:2020-04-01 00:00:00
abstract::Body mass index (BMI) is one of the most important outcome predictors in patients with anorexia nervosa (AN). A low premorbid BMI percentile calculated by the patients recalled premorbid weight and the height at first admission has been found to predict the BMI at first inpatient admission. In this study, we sought to...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0605-0
更新日期:2015-05-01 00:00:00
abstract::Research consistently chronicles a variety of mental health difficulties that plague institutionally reared children, including attention-deficit/hyperactivity disorder (ADHD), even if not all institutionalized children evince such problems. In seeking to extend work in this area, this research on gene × environment (...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0890-x
更新日期:2017-03-01 00:00:00
abstract::The family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous o...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-018-1240-y
更新日期:2019-06-01 00:00:00