Abstract:
:Somatic disorders occur more often in adult psychiatric patients than in the general adult population. However, in child and adolescent psychiatry this association is unclear, mainly due to a lack of integration of existing data. To address this issue, we here present a systematic review on medical comorbidity in the two major developmental disorders autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) and formulate clinical recommendations. The literature was searched using the PubMed and PsycINFO databases (2000-1 May 2016) with the keywords "[((child and adolescent) AND (Autism OR Attention Deficit Hyperactivity Disorder* OR ADHD)) AND ("Cardiovascular Diseases" [Mesh] OR "Endocrine System Diseases" [Mesh] OR "Immune System Diseases" [Mesh] OR "Neurobehavioral Manifestations" [Mesh] OR "Gastrointestinal Disorders" [Mesh] OR Somatic OR Autoimmune disease OR Nervous system disease OR Infection OR Infectious disease)]. Two raters independently assessed the quality of the eligible studies. The initial search identified 5278 articles. Based on inclusion and exclusion criteria 104 papers were selected and subsequently subjected to a quality control. This quality was assessed according to a standardized and validated set of criteria and yielded 29 studies for inclusion. This thorough literature search provides an overview of relevant articles on medical comorbidity in ADHD and/or ASD, and shows that medical disorders in these children and adolescents appear to be widespread. Those who work with children with ASD and/or ADHD should be well aware of this and actively promote routine medical assessment. Additionally, case-control studies and population-based studies are needed to provide reliable prevalence estimates. Future studies should furthermore focus on a broader evaluation of medical disorders in children and adolescents with ADHD and/or ASD to improve treatment algorithm in this vulnerable group.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Muskens JB,Velders FP,Staal WGdoi
10.1007/s00787-017-1020-0subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1093-1103issue
9eissn
1018-8827issn
1435-165Xpii
10.1007/s00787-017-1020-0journal_volume
26pub_type
杂志文章,评审abstract::Seven children and young adults with definite signs of Asperger syndrome were administered a battery of tests designed to test: intelligence; left and right cerebral hemisphere functioning; ability to discriminate eye gaze; and social judgment. The subjects revealed a non significant tendency to have a higher verbal I...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF01978114
更新日期:1994-10-01 00:00:00
abstract::Concentrations of melatonin in overnight and first-voiding urine samples from 10 people with autism, 15 parents, 1 grandparent, 9 sibs without autism, and 10 healthy, unrelated volunteers, were measured by radioimmunoassay. Those with autism had significantly higher melatonin concentrations in the first voiding sample...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF02098862
更新日期:1993-04-01 00:00:00
abstract::Research shows that paternal psychological distress is associated with child emotional and behavioural difficulties. However, little is known about the direction of this association including whether it is bidirectional. The aim of this study was to explore the reciprocal relationships between paternal psychological d...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01642-0
更新日期:2020-09-17 00:00:00
abstract::Previous studies have suggested environmental factors may contribute to the risk of attention-deficit/hyperactivity disorder (ADHD). The current meta-analysis examined (1) the difference in the duration of maternal breastfeeding between children with and without ADHD, and (2) the association between maternal breastfee...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,meta分析
doi:10.1007/s00787-018-1182-4
更新日期:2019-01-01 00:00:00
abstract::Formal thought disorder (FTD) is a disruption in the flow of thought, which is inferred from disorganisation of spoken language. FTD in autism spectrum disorders (ASD) might be a precursor of psychotic disorders or a manifestation of ASD symptom severity. The current longitudinal study is a seven-year follow-up of 91 ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0552-9
更新日期:2015-02-01 00:00:00
abstract::Recent work in the field of developmental dyslexia has emphasized the large-scale neural aspects of the disorder as measured by means of contemporary imaging techniques, electrophysiology, and post-mortem analyses. This article presents findings from these research domains and comprehensively reviews their relevance w...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-004-0361-7
更新日期:2004-06-01 00:00:00
abstract::Identifying early-onset schizophrenia spectrum disorders (SSD) at a very early stage remains challenging. To assess the diagnostic predictive value of multiple types of data at the emergence of early-onset first-episode psychosis (FEP), various support vector machine (SVM) classifiers were developed. The data were fro...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1007/s00787-014-0593-0
更新日期:2015-04-01 00:00:00
abstract::Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-018-1172-6
更新日期:2018-09-01 00:00:00
abstract::The main aim of this study was to examine the moderating effects of attention deficit hyperactivity disorder (ADHD) on anxiety disorders in children. Data were analyzed from a large referred sample of children with anxiety disorder without comorbid ADHD (anxiety disorder, N = 253), anxiety disorder plus comorbid ADHD ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-009-0041-8
更新日期:2010-02-01 00:00:00
abstract::Fear has been assigned a central role in models of obsessive-compulsive disorder (OCD), but empirical investigations into the emotions that underpin OCD symptoms are few, especially in pediatric samples. Using validated, clinician-led structured interviews, 124 youth with OCD reported on the presence and severity of s...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01514-7
更新日期:2020-03-24 00:00:00
abstract::Given the known behavior effects of oxytocin,and in particular its putative effect on trust, affiliation and anxiety, we hypothesized that oxytocin may be involved in the development and expression of callous-unemotional traits in children with aggressive antisocial behavior. We recruited 162 children between the ages...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-012-0240-6
更新日期:2012-03-01 00:00:00
abstract::Psychological resilience refers to the ability to adapt effectively in the face of adversity, which is closely related to an individual's psychological and physical health and well-being. Although previous behavioural studies have shown sex differences in psychological resilience, little is known about the neural basi...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01421-6
更新日期:2020-08-01 00:00:00
abstract::Several studies have demonstrated associations between neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD), and the immune system, including autoimmune diseases. Since ADHD and many autoimmune diseases show sex-specific properties, such associations may also differ by sex. Using Norwegi...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1056-1
更新日期:2018-05-01 00:00:00
abstract::The school-based mental health promotion and suicide prevention universal program Youth Aware of Mental Health (YAM) significantly reduces incident suicide attempts and severe suicidal ideation. This paper aims at elucidating psychological mechanisms underlying YAM's efficacy. Our hypothesis is that YAM operates throu...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01476-w
更新日期:2020-12-01 00:00:00
abstract::It has been suggested that neurotrophins are involved in the etiopathogenesis of attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neu...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0898-2
更新日期:2017-03-01 00:00:00
abstract::Worldwide, approximately one in eight children or adolescents suffers from a mental disorder. The present study was designed to determine the self-reported prevalence of mental health problems in children aged 6-11 years across eight European countries including Italy, France, Germany, the Netherlands, Lithuania, Bulg...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-017-1073-0
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:The present study investigated the relationship between daytime symptomatology and nightmare frequency in school-aged children by eliciting daytime symptoms and nightmare frequency from children directly in addition to questionnaires completed by their parents. METHODS:A sample of 4,834 parents and 4,531 of ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-008-0697-5
更新日期:2009-01-01 00:00:00
abstract::The impact of premorbid social and intellectual functioning in childhood and early adolescence on the developmental course of schizophrenia is not sufficiently understood. In a retrospective case study (93 consecutive in-patients, 43 males and 50 females) of first-episode psychosis occurring in adolescence, the relati...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00539928
更新日期:1997-12-01 00:00:00
abstract::Twin studies described a strongly heritable component of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. However, findings varied considerably between studies. In addition, ADHD presents with a high rate of comorbid disorders and associated psychopathology. Therefore, this literature revie...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/s00787-010-0097-5
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The impact of attention deficit hyperactive disorder (ADHD) in the Netherlands on health care utilisation, costs and quality of life of these children, as well as of their parents is unknown. OBJECTIVE:The aim of this study was to assess the direct medical costs of patients suffering from ADHD and their qua...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0603-6
更新日期:2007-08-01 00:00:00
abstract::Sleep disturbances are common in the pediatric population and should primarily be treated non-pharmacologically. Most medicines for sleep disturbances are not approved for pediatric use and data on long-term safety is scarce. In Sweden, melatonin is classified as a prescription medicine. The aim of the present study w...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01598-1
更新日期:2020-07-22 00:00:00
abstract::This project describes the dissemination of an evidence-based parenting skills intervention by training social and health workers with little or no mental health background so that they themselves train mothers of children with behavioral problems in impoverished communities in a developing country. The Strengths and ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-010-0099-3
更新日期:2010-08-01 00:00:00
abstract::The family relationships of patients with anorexia nervosa (AN) have been extensively studied over recent years. However, using case-control designs with unrelated controls is subject to various cultural and familial biases. Studying subjective differential perceptions of family relationships in sister-pairs discordan...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-003-0319-1
更新日期:2003-06-01 00:00:00
abstract::Psychiatric comorbidity in traumatized youth is prevalent, but such associations between two disorders may be confounded with other comorbid conditions. Few studies have examined the unique relationships among multiple disorders. Which disorders maximally explain the relationships between others and whether such disor...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01400-x
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the longterm efficacy, safety, and tolerability of risperidone, over a cumulative period of 3 years, in treating children with disruptive behaviour disorders and below average intelligence (IQ 35-84). METHOD:This trial included 35 children (aged 6-16 years), diagnosed with...
journal_title:European child & adolescent psychiatry
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00787-006-0504-0
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:To use growth mixture modelling (GMM) to identify subgroups of children with attention deficit hyperactive disorder (ADHD) who have different pharmacodynamic profiles in response to extended release methylphenidate as assessed in a laboratory classroom setting. METHODS:GMM analysis was performed on data fro...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0667-3
更新日期:2008-06-01 00:00:00
abstract::Family and twin studies of developmental dyslexia have consistently shown that there is a significant heritable component for this disorder. However, any genetic basis for the trait is likely to be complex, involving reduced penetrance, phenocopy, heterogeneity and oligogenic inheritance. This complexity results in re...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/pl00010694
更新日期:1999-01-01 00:00:00
abstract::Research into Pathological Demand Avoidance (PDA), which has been suggested to be a subgroup within the Autism Spectrum Disorder (ASD), is almost nonexistent in spite of the frequent reference to the condition in clinical practice. The total population of 15 to 24-year-olds in the Faroe Islands was screened for ASD, a...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0647-3
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Given the dosing limitations of methylphenidate short-acting preparations in treating ADHD, galenics with longer release of the substance were developed mainly to avoid drug intake during school hours. OBJECTIVES:This investigation was conducted to assess the efficacy and the duration of action of a new ext...
journal_title:European child & adolescent psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00787-004-1009-3
更新日期:2004-01-01 00:00:00
abstract::Animal findings of long-term effects of maternal behaviors mediated via altered GR gene expression will, if translated into humans, have far reaching implications for our understanding of child and adolescent psychopathology. We have previously shown that mothers' self-reported stroking of their infants modifies assoc...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0886-6
更新日期:2017-03-01 00:00:00