Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers.

Abstract:

:Research consistently chronicles a variety of mental health difficulties that plague institutionally reared children, including attention-deficit/hyperactivity disorder (ADHD), even if not all institutionalized children evince such problems. In seeking to extend work in this area, this research on gene × environment (GXE) interplay investigated whether the effect of the quality of institutional care-most notably, caregiver intrusiveness-on ADHD symptoms is moderated by the serotonin transporter (5-HTTLPR) polymorphism. One hundred and twenty-seven institutionalized preschoolers were evaluated using the Child Behavior Checklist. Caregiver-rated attention problems and hyperactivity were unrelated to both 5-HTTLPR polymorphism and caregiver intrusiveness. A significant GXE effect, independent of age at placement or duration of institutionalization, emerged, however, consistent with the differential-susceptibility hypothesis: s/s homozygotes manifest the most and least ADHD symptoms when they experienced, respectively, more and less intrusive caregiving. These results provide new insight into the reasons why some institutionalized children, but not others, exhibit ADHD symptoms.

authors

Baptista J,Belsky J,Mesquita A,Soares I

doi

10.1007/s00787-016-0890-x

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

303-313

issue

3

eissn

1018-8827

issn

1435-165X

pii

10.1007/s00787-016-0890-x

journal_volume

26

pub_type

杂志文章
  • The outcome of adolescent eating disorders: findings from an international collaborative study.

    abstract::Within the International Collaborative Outcome Study of Eating Disorders in Adolescence (ICOSEDA) we studied the clinical features, treatment, and outcome in consecutive cohorts of adolescent patients at five sites in former West Berlin and East Berlin, Zurich, Sofia and Bucharest. A total of N = 242 patients were fol...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00787-003-1112-x

    authors: Steinhausen HC,Boyadjieva S,Griogoroiu-Serbanescu M,Neumärker KJ

    更新日期:2003-01-01 00:00:00

  • Measurement and data quality in longitudinal research.

    abstract::The importance of paying attention to scale levels is emphasized and it is pointed out that Steven's hierarchy of ratio, interval, ordinal, and nominal scales is too narrow; other important scale properties have to be considered. For instance, sometimes a carefully constructed variable on a nominal scale contains more...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF00538540

    authors: Bergman LR

    更新日期:1996-01-01 00:00:00

  • Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review.

    abstract::Somatic disorders occur more often in adult psychiatric patients than in the general adult population. However, in child and adolescent psychiatry this association is unclear, mainly due to a lack of integration of existing data. To address this issue, we here present a systematic review on medical comorbidity in the ...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-017-1020-0

    authors: Muskens JB,Velders FP,Staal WG

    更新日期:2017-09-01 00:00:00

  • Involvement of fear, incompleteness, and disgust during symptoms of pediatric obsessive-compulsive disorder.

    abstract::Fear has been assigned a central role in models of obsessive-compulsive disorder (OCD), but empirical investigations into the emotions that underpin OCD symptoms are few, especially in pediatric samples. Using validated, clinician-led structured interviews, 124 youth with OCD reported on the presence and severity of s...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01514-7

    authors: Cervin M,Perrin S,Olsson E,Claesdotter-Knutsson E,Lindvall M

    更新日期:2020-03-24 00:00:00

  • Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among school-aged children. It is highly symptomatic and associated with significant impairment. This review examines the role of stimulant medications in the treatment of children and adolescents with ADHD. Publishe...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-012-0286-5

    authors: Hodgkins P,Shaw M,Coghill D,Hechtman L

    更新日期:2012-09-01 00:00:00

  • P300 amplitude and latency in autism spectrum disorder: a meta-analysis.

    abstract::Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder. Evidence suggests that ASD patients have abnormalities in information processing. Event-related potential (ERP) technique can directly record brain neural activity in real time. P300 is a positive ERP component which can measure the neuroele...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00787-016-0880-z

    authors: Cui T,Wang PP,Liu S,Zhang X

    更新日期:2017-02-01 00:00:00

  • Behavior in children with Prader-Willi syndrome before and during growth hormone treatment: a randomized controlled trial and 8-year longitudinal study.

    abstract::Information on behavior of children with Prader-Willi syndrome (PWS) and the effect of growth hormone (GH) treatment is scarce. Parents report less problem behavior during GH treatment. Forty-two pre-pubertal children, aged 3.5-14 years were studied in a randomized controlled GH trial (RCT) during 2 years, followed by...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00787-014-0662-4

    authors: Lo ST,Siemensma EP,Festen DA,Collin PJ,Hokken-Koelega AC

    更新日期:2015-09-01 00:00:00

  • Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS).

    abstract::Little is known about the natural history of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). This study prospectively followed 33 children with PANDAS for up to 4.8 years (mean 3.3 ± 0.7 years) after enrollment in a 24-week randomized, double-blind, place...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00787-017-1077-9

    authors: Leon J,Hommer R,Grant P,Farmer C,D'Souza P,Kessler R,Williams K,Leckman JF,Swedo S

    更新日期:2018-05-01 00:00:00

  • Service-level variation, patient-level factors, and treatment outcome in those seen by child mental health services.

    abstract::Service comparison is a policy priority but is not without controversy. This paper aims to investigate the amount of service-level variation in outcomes in child mental health, whether it differed when examining outcomes unadjusted vs. adjusted for expected change over time, and which patient-level characteristics wer...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-016-0939-x

    authors: Edbrooke-Childs J,Macdougall A,Hayes D,Jacob J,Wolpert M,Deighton J

    更新日期:2017-06-01 00:00:00

  • Elevated daytime melatonin concentrations in autism: A pilot study.

    abstract::Concentrations of melatonin in overnight and first-voiding urine samples from 10 people with autism, 15 parents, 1 grandparent, 9 sibs without autism, and 10 healthy, unrelated volunteers, were measured by radioimmunoassay. Those with autism had significantly higher melatonin concentrations in the first voiding sample...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF02098862

    authors: Ritvo ER,Ritvo R,Yuwiler A,Brothers A,Freeman BJ,Plotkin S

    更新日期:1993-04-01 00:00:00

  • A Danish population-based twin study on autism spectrum disorders.

    abstract::Genetic epidemiological studies of Autism Spectrum Disorders (ASDs) based on twin pairs ascertained from the population and thoroughly assessed to obtain a high degree of diagnostic validity are few. All twin pairs aged 3-14 years in the nationwide Danish Twin Registry were approached. A three-step procedure was used....

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-013-0419-5

    authors: Nordenbæk C,Jørgensen M,Kyvik KO,Bilenberg N

    更新日期:2014-01-01 00:00:00

  • Health care consumption and psychiatric diagnoses among adolescent girls 1 and 2 years after a first-time registered child sexual abuse experience: a cohort study in the Stockholm Region.

    abstract::Child sexual abuse (CSA) is a crime against human rights with severe health consequences, and suicidal actions, stress, eating disorders, and borderline disorder are common among survivors of CSA. The objective of this study was to analyze how health care consumption patterns developed among adolescent girls in the St...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-020-01670-w

    authors: Rajan G,Syding S,Ljunggren G,Wändell P,Wahlström L,Philips B,Svedin CG,Carlsson AC

    更新日期:2020-11-01 00:00:00

  • The risk of psychiatric disorders among Finnish ART and spontaneously conceived children: Finnish population-based register study.

    abstract::Evidence regarding the psychiatric morbidity of children born after Assisted Reproductive Techniques (ART) is inconsistent and limited. While normal mental well-being for ART children is usually reported, concerns are still being raised. Previous studies examine only some psychiatric disorders, but not all of them, ig...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-019-01433-2

    authors: Rissanen E,Gissler M,Lehti V,Tiitinen A

    更新日期:2020-08-01 00:00:00

  • Asperger's syndrome and high-functioning autism: language, motor and cognitive profiles.

    abstract::The objective of this study is to compare the cognitive profile, the motor and language functioning and the psychosocial adaptation of children with Asperger syndrome (AS) and with high-functioning autism (HFA). Subjects were recruited through the department Autism and Developmental Disorders of the Heckscher-Klinikum...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-009-0057-0

    authors: Noterdaeme M,Wriedt E,Höhne C

    更新日期:2010-06-01 00:00:00

  • Deliberate self-harm in young people: differences in prevalence and risk factors between the Netherlands and Belgium.

    abstract:BACKGROUND:This study aimed to examine prevalence and risk factors of deliberate self-harm in Dutch and Dutch-speaking Belgian adolescents. METHOD:A cross sectional survey using an anonymous self report questionnaire was performed in both countries. Data on 4,431 Belgian and 4,458 Dutch 15-16 year-old school pupils we...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-007-0652-x

    authors: Portzky G,De Wilde EJ,van Heeringen K

    更新日期:2008-04-01 00:00:00

  • Slow cortical potentials neurofeedback in children with ADHD: comorbidity, self-regulation and clinical outcomes 6 months after treatment in a multicenter randomized controlled trial.

    abstract::Despite sizeable short-term effects of neurofeedback (NF) therapy on attention-deficit and hyperactivity disorder (ADHD), longer-term clinical, comorbidity and self-regulation outcomes are less systematically studied. The aim of this largest NF follow-up to date was to evaluate these outcomes 6 months after NF compare...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00787-018-01271-8

    authors: Aggensteiner PM,Brandeis D,Millenet S,Hohmann S,Ruckes C,Beuth S,Albrecht B,Schmitt G,Schermuly S,Wörz S,Gevensleben H,Freitag CM,Banaschewski T,Rothenberger A,Strehl U,Holtmann M

    更新日期:2019-08-01 00:00:00

  • Comparative efficacy of once-a-day extended-release methylphenidate, two-times-daily immediate-release methylphenidate, and placebo in a laboratory school setting.

    abstract:BACKGROUND:Given the dosing limitations of methylphenidate short-acting preparations in treating ADHD, galenics with longer release of the substance were developed mainly to avoid drug intake during school hours. OBJECTIVES:This investigation was conducted to assess the efficacy and the duration of action of a new ext...

    journal_title:European child & adolescent psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00787-004-1009-3

    authors: Döpfner M,Gerber WD,Banaschewski T,Breuer D,Freisleder FJ,Gerber-von Müller G,Günter M,Hässler F,Ose C,Rothenberger A,Schmeck K,Sinzig J,Stadler C,Uebel H,Lehmkuhl G

    更新日期:2004-01-01 00:00:00

  • Differentiating between ADHD and ASD in childhood: some directions for practitioners.

    abstract:: ...

    journal_title:European child & adolescent psychiatry

    pub_type: 社论

    doi:10.1007/s00787-018-1165-5

    authors: Rommelse N,Visser J,Hartman C

    更新日期:2018-06-01 00:00:00

  • Perspectives of eating disorders from the Charité Hospital in Berlin.

    abstract::Eating disorders have attracted steadily expanding clinical and scientific attention since second half of the 19(th) century and, particularly, after the core descriptions of anorexia nervosa had been delivered by Gull and Lasègue. In this review, we attempt to illustrate perspectives on eating disorders that have eme...

    journal_title:European child & adolescent psychiatry

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s00787-003-1102-z

    authors: Neumärker KJ,Bartsch AJ

    更新日期:2003-01-01 00:00:00

  • Autism associated with tetrasomy 15: A further report.

    abstract::Association of autism with tetrasomy of chromosome 15 has recently been described in six males. In this report, we describe the occurrence of autism in a girl with tetrasomy of chromosome 15. The patient showed hyperactivity, hand-flapping, short-stature, eye abnormalities, and hypotonia, which have been reported in m...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF02098582

    authors: Ghaziuddin M,Sheldon S,Venkataraman S,Tsai L,Ghaziuddin N

    更新日期:1993-10-01 00:00:00

  • The association between preschool behavioural problems and internalizing difficulties at age 10-12 years.

    abstract::The aim was to study the association between preschool behavioural problems and emotional symptoms in 10- to 12-year-old children. The study was based on the Aarhus Birth cohort, Denmark, and included 1,336 children. Based on the parent-administered preschool behaviour questionnaire (PBQ), we identified three not mutu...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-010-0128-2

    authors: Slemming K,Sørensen MJ,Thomsen PH,Obel C,Henriksen TB,Linnet KM

    更新日期:2010-10-01 00:00:00

  • Recurrent abdominal pain and headache--psychopathology, life events and family functioning.

    abstract::We assessed the psychopathology of children and adolescents with Recurrent Abdominal Pain (RAP) and tension-type headaches (TTH), the psychopathology and Expressed Emotion (EE) of their mothers and family functioning. Additionally, we assessed the relationship of negative Life Events (LE) to RAP and headaches. Sixty-n...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-002-0276-0

    authors: Liakopoulou-Kairis M,Alifieraki T,Protagora D,Korpa T,Kondyli K,Dimosthenous E,Christopoulos G,Kovanis T

    更新日期:2002-06-01 00:00:00

  • Effectiveness of outpatient cognitive-behavioral therapy for adolescents under routine care conditions on behavioral and emotional problems rated by parents and patients: an observational study.

    abstract::Few studies have examined the effectiveness of outpatient cognitive-behavioral therapy (CBT) delivered in routine care settings for children and adolescents with mental disorders. This observational study examined changes in behavioral and emotional problems of adolescents with mental disorders during routine outpatie...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-017-1021-z

    authors: Walter D,Dachs L,Faber M,Goletz H,Goertz-Dorten A,Hautmann C,Kinnen C,Rademacher C,Schuermann S,Metternich-Kaizman TW,Doepfner M

    更新日期:2018-01-01 00:00:00

  • Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium.

    abstract::Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used a...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章,评审

    doi:10.1007/s00787-018-1172-6

    authors: Freitag CM,Konrad K,Stadler C,De Brito SA,Popma A,Herpertz SC,Herpertz-Dahlmann B,Neumann I,Kieser M,Chiocchetti AG,Schwenck C,Fairchild G

    更新日期:2018-09-01 00:00:00

  • Problem coping skills, psychosocial adversities and mental health problems in children and adolescents as predictors of criminal outcomes in young adulthood.

    abstract::The purpose of this study was to test child and adolescent psychosocial and psychopathological risk factors as predictors of adult criminal outcomes in a Swiss community sample. In particular, the role of active and avoidant problem coping in youths was analysed. Prevalence rates of young adult crime convictions based...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-013-0458-y

    authors: Aebi M,Giger J,Plattner B,Metzke CW,Steinhausen HC

    更新日期:2014-05-01 00:00:00

  • Children and adolescents with Tourette's disorder in the USA versus Argentina: behavioral differences may reflect cultural factors.

    abstract::To explore behavioral differences as possible cultural factors in presentation of psychiatric comorbidity in two clinically referred, consecutively ascertained samples of youth with Tourette's disorder (TD) from New York and Buenos Aires. Subjects were evaluated between 2002 and 2010 at the Tics and Tourette's Clinica...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-013-0406-x

    authors: Samar SM,Moyano MB,Braña-Berríos M,Irazoqui G,Matos A,Kichic R,Gellatly R,Ibanez-Gomez L,Zwilling AL,Petkova E,Coffey BJ

    更新日期:2013-11-01 00:00:00

  • Maternal pre-pregnancy weight status and health care use for mental health conditions in the offspring.

    abstract::The objective of this study was to examine the relationship between pre-pregnancy maternal weight status and offspring physician visits for mental health conditions in childhood and adolescence. We conducted a population-based retrospective cohort study of singleton infants born between the years of 1989 and 1993 usin...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-019-01312-w

    authors: Grudzinski A,Campbell LA,Liu L,Brown MM,Dodds L,Kuhle S

    更新日期:2019-11-01 00:00:00

  • Prevalence and impact of insomnia in children and adolescents with body dysmorphic disorder undergoing multimodal specialist treatment.

    abstract::Pediatric body dysmorphic disorder (BDD) is challenging to treat. This study aimed to establish the prevalence of insomnia in youth with BDD and explore its impact on clinical outcomes. Sixty-six children and adolescents with BDD consecutively referred to a specialist clinic completed a range of clinical measures, inc...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-019-01442-1

    authors: Sevilla-Cermeño L,Rautio D,Andrén P,Hillborg M,Silverberg-Morse M,Lahera G,Mataix-Cols D,Fernández de la Cruz L

    更新日期:2020-09-01 00:00:00

  • Psychometric properties of two ADHD questionnaires: comparing the Conners' scale and the FBB-HKS in the general population of German children and adolescents--results of the BELLA study.

    abstract:BACKGROUND AND OBJECTIVE:To examine and compare the psychometric properties of two short screening instruments for children and adolescents suffering from attention deficit-/ hyperactivity disorder (ADHD). The Conners' Hyperactivity Index consists of ten items that assess symptoms of hyperactivity through self-report a...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/s00787-008-1012-1

    authors: Erhart M,Döpfner M,Ravens-Sieberer U,BELLA study group.

    更新日期:2008-12-01 00:00:00

  • Premorbid adjustment and remission of positive symptoms in first-episode psychosis.

    abstract::The impact of premorbid social and intellectual functioning in childhood and early adolescence on the developmental course of schizophrenia is not sufficiently understood. In a retrospective case study (93 consecutive in-patients, 43 males and 50 females) of first-episode psychosis occurring in adolescence, the relati...

    journal_title:European child & adolescent psychiatry

    pub_type: 杂志文章

    doi:10.1007/BF00539928

    authors: Amminger GP,Resch F,Mutschlechner R,Friedrich MH,Ernst E

    更新日期:1997-12-01 00:00:00