Abstract：
:The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure-stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE(-/-) and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE(-/-) mice aortas exhibit a saturation-type increase with respect to age.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Waffenschmidt T,Cilla M,Sáez P,Pérez MM,Martínez MA,Menzel A,Peña Edoi
10.1016/j.jbiomech.2016.01.043subject
Has Abstractpub_date
2016-08-16 00:00:00pages
2390-7issue
12eissn
0021-9290issn
1873-2380pii
S0021-9290(16)30126-9journal_volume
49pub_type
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