All-Optical Method to Assess Stromal Concentration of Riboflavin in Conventional and Accelerated UV-A Irradiation of the Human Cornea.

abstract：PURPOSE:Retinopathy of prematurity (ROP) is a major cause of visual handicap in the pediatric population. To date, this disorder is thought to stem from deficient retinal vascularization. Intriguingly, functional electrophysiological studies in patients with mild or moderate ROP and in the oxygen-induced retinopathy (O...

journal_title：Investigative ophthalmology & visual science

authors： Shao Z,Dorfman AL,Seshadri S,Djavari M,Kermorvant-Duchemin E,Sennlaub F,Blais M,Polosa A,Varma DR,Joyal JS,Lachapelle P,Hardy P,Sitaras N,Picard E,Mancini J,Sapieha P,Chemtob S

更新日期：2011-08-05 00:00:00

abstract：:The effects of x-rays and three chemical agents, known to cause intraocular inflammation in mammalian eyes, were studied on the chicken eye because this species was reported to be insensitive to the cataractogenic effects of x-rays. Intravitreal injection of Shigella endotoxin and topical and/or intravitreal administr...

journal_title：Investigative ophthalmology & visual science

authors： Stetz DE,Bito LZ

更新日期：1978-05-01 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS). METHODS:Samples were collected from EIU-susceptible Lewis rats and EIU-re...

journal_title：Investigative ophthalmology & visual science

authors： de Vos AF,van Haren MA,Verhagen C,Hoekzema R,Kijlstra A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

journal_title：Investigative ophthalmology & visual science

authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

更新日期：2011-06-01 00:00:00

abstract：Purpose:To describe the pathology of AMD in eyes with geographic atrophy (GA) using confocal scanning laser ophthalmoscopy (SLO) blue light autofluorescence (BAF), and near-infrared (IR) AF and to correlate it with the histology and immunohistochemistry analysis at the margins of the GA lesion. Methods:Enucleated, fix...

journal_title：Investigative ophthalmology & visual science

authors： Bonilha VL,Bell BA,Hu J,Milliner C,Pauer GJ,Hagstrom SA,Radu RA,Hollyfield JG

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To assess photoreceptor morphology in patients with Stargardt's disease and fundus flavimaculatus using ultrahigh-resolution optical coherence tomography (UHR-OCT) and correlate it with visual acuity (VA). METHODS:This was a prospective observational case series. Fourteen patients with Stargardt's disease (nin...

journal_title：Investigative ophthalmology & visual science

authors： Ergun E,Hermann B,Wirtitsch M,Unterhuber A,Ko TH,Sattmann H,Scholda C,Fujimoto JG,Stur M,Drexler W

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The immediate early gene Egr-1 is thought to form part of the pathway that mediates abnormal ocular growth. This study investigated whether the mRNA expression levels of Egr-1 in a mammalian retina are modulated differentially, depending on the direction of ocular growth. METHODS:To induce accelerated growth a...

journal_title：Investigative ophthalmology & visual science

authors： Ashby RS,Zeng G,Leotta AJ,Tse DY,McFadden SA

更新日期：2014-07-22 00:00:00

abstract：Purpose:To investigate the role of mitogen-activated protein kinase-activated protein kinase-2 (MK2) in ocular surface damage of dry eye. Methods:MK2 inhibition was performed in mice subjected to desiccating stress (DS) by topical application of MK2 inhibitor (MK2i) or vehicle eye drops. The total and phosphorylated M...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Bu J,Yang Y,Lin X,Cai X,Huang C,Zheng X,Ouyang W,Li W,Zhang X,Liu Z

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To determine the functional contribution of retinoic acid receptor (RAR)-alpha in the developing murine neural retina, through a phenotypic analysis of the corresponding null mutants. METHODS:RARalpha mutant (Rara(-/-)) mice were compared with wild-type littermates at several stages of pre- and postnatal devel...

journal_title：Investigative ophthalmology & visual science

authors： Cammas L,Trensz F,Jellali A,Ghyselinck NB,Roux MJ,Dollé P

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. METHODS:TM specimens were collected from 146 patie...

journal_title：Investigative ophthalmology & visual science

authors： Fernández-Durango R,Fernández-Martínez A,García-Feijoo J,Castillo A,de la Casa JM,García-Bueno B,Pérez-Nievas BG,Fernández-Cruz A,Leza JC

更新日期：2008-06-01 00:00:00

abstract：:Isotonic, neutral buffered solutions of benzalkonium chloride or chlorhexidine digluconate were applied topically to one eye of rabbits or human subjects. Contralateral control eyes received phosphate buffered saline as placebo. One-half hour later, the tear film of both eyes was loaded with nonpreserved sodium fluore...

journal_title：Investigative ophthalmology & visual science

authors： Burstein NL

更新日期：1984-12-01 00:00:00

abstract：PURPOSE:P1 is the major positive component of pattern-reversal visual evoked potentials (PR-VEPs). The rapid decrease of its latency correlates with the progressive myelination in the developing infant brain, which affects signal transmission in the visual system. An age-dependent phase shift, analogous to P1 peak late...

journal_title：Investigative ophthalmology & visual science

authors： Mikó-Baráth E,Markó K,Budai A,Török B,Kovacs I,Jandó G

更新日期：2014-04-21 00:00:00

abstract：Purpose:The lysozyme 2 (Lyz2 or LysM) cre mouse is extensively used to achieve genetic manipulation in myeloid cells and it has been widely employed in retinal research. However, LysM has been recently described to be expressed in brain neurons and there is a debate on whether it is also expressed by resident microglia...

journal_title：Investigative ophthalmology & visual science

authors： Fouda AY,Xu Z,Narayanan SP,Caldwell RW,Caldwell RB

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To determine whether caspase or cathepsin pathways are activated in human retinal pigment epithelial cells (ARPE-19) after exposure to 7-ketocholesterol (7kCh). METHODS:ARPE-19 cells were exposed to 7kCh with or without z-VAD-fmk, a pan-caspase inhibitor. Caspase-3, -8, and -9 activities were measured by a flu...

journal_title：Investigative ophthalmology & visual science

authors： Luthra S,Fardin B,Dong J,Hertzog D,Kamjoo S,Gebremariam S,Butani V,Narayanan R,Mungcal JK,Kuppermann BD,Kenney MC

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Drusen are risk factors for age-related macular degeneration and have been shown to negatively impact cells of the RPE and retina. In this study, the effects of drusen on the synaptic machinery of retinal photoreceptors are investigated. METHODS:Human donor eye tissue containing retina, RPE, and choroid was pr...

journal_title：Investigative ophthalmology & visual science

authors： Johnson PT,Brown MN,Pulliam BC,Anderson DH,Johnson LV

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Lenses from selenite-treated animals develop reversible "cold cataract" at a lower temperature than is required for lenses from age-matched control animals. This unexplained, stabilized phase transition is readily observed in intact lenses 36 to 48 hours after treatment and occurs in lenses before the appearanc...

journal_title：Investigative ophthalmology & visual science

authors： Mitton KP,Hess JL,Bunce GE

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in th...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To describe the age-, gender-, and cause-specific 5-year incidence of bilateral visual impairment in participants in the Melbourne Visual Impairment Project, Victoria, Australia. METHODS:Participants aged 40 years and older were recruited from Melbourne, Victoria, Australia, by random cluster sampling. The mea...

journal_title：Investigative ophthalmology & visual science

authors： Dimitrov PN,Mukesh BN,McCarty CA,Taylor HR

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:Injury to the adult optic nerve, caused mechanically or by diseases, is still not reparable because the retinal ganglion cells (RGCs) are not allowed to regrow their axons and die retrogradely, although they possess the intrinsic propensity to regenerate axons in experimental conditions. METHODS:In vitro propa...

journal_title：Investigative ophthalmology & visual science

authors： Charalambous P,Hurst LA,Thanos S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To develop an imaging technique that maps the distribution of free cystine in the rat lens at subcellular resolution and enables cystine accumulation to be compared with the expression of the cystine-glutamate exchanger (Xc-). METHODS:Whole lenses were fixed, cryoprotected, and then cryosectioned in either an ...

journal_title：Investigative ophthalmology & visual science

authors： Li L,Lim J,Jacobs MD,Kistler J,Donaldson PJ

更新日期：2007-03-01 00:00:00

abstract：:The effect of systemic hypoxia on the maintained firing rate (MFR) of single retinal ganglion cells has been measured in the cat at a constant luminance level. Systemic hypoxia was produced by reducing the percentage of oxygen in the respiratory mixture under forced ventilation so that arterial PCO2 and pH were consta...

journal_title：Investigative ophthalmology & visual science

authors： Alder VA,Constable IJ

更新日期：1981-09-01 00:00:00

abstract：PURPOSE:To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS:The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlands. A total of 4822 subjects who at baseline were a...

journal_title：Investigative ophthalmology & visual science

authors： van Leeuwen R,Ikram MK,Vingerling JR,Witteman JC,Hofman A,de Jong PT

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:To compare in vitro, on the human reconstituted corneal epithelial SkinEthics model, and in vivo, using an acute rabbit toxicological model, the effects of a benzalkonium chloride (BAK)-preserved solution of latanoprost and a preservative-free (PF) latanoprost solution. METHODS:In vitro, the three-dimensional ...

journal_title：Investigative ophthalmology & visual science

authors： Pauly A,Roubeix C,Liang H,Brignole-Baudouin F,Baudouin C

更新日期：2012-12-13 00:00:00

abstract：Purpose:A recent proposal for why glaucomatous perimetric sensitivities of approximately 15 to 19 dB or less are unreliable involves the idea that the neural response of normal retinal ganglion cells saturates for intense perimetric stimuli. A predicted consequence of this saturation is that the neural response for two...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ,McKendrick AM,Turpin A

更新日期：2016-11-01 00:00:00

abstract：Purpose:To investigate the effect of reducing high glucose (HG)-induced lysyl oxidase (LOX) overexpression and increased activity on retinal endothelial cell apoptosis. Methods:Rat retinal endothelial cells (RRECs) were grown in normal (N) or HG (30 mM glucose) medium for 7 days. In parallel, RRECs were grown in HG me...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Mecham RP,Trackman PC,Roy S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：:Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4....

journal_title：Investigative ophthalmology & visual science

authors： Braakman R,van der Valk P,van Delft JL,de Wolff-Rouendaal D,Oosterhuis JA

更新日期：1989-05-01 00:00:00

abstract：:Hypothesis-driven science is expected to result in a continuum of studies and findings along a discrete path. By comparison, serendipity can lead to new directions that branch into different paths. Herein, I describe a diverse series of findings that were motivated by hypotheses, but driven by serendipity. I summarize...

journal_title：Investigative ophthalmology & visual science

authors： Fischer AJ

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:Nerve growth factor (NGF) is a neuropeptide essential for the development, survival, growth, and differentiation of corneal cells. Its effects are mediated by both TrkA and p75 receptors. Clinically relevant use of NGF was introduced to treat neurotrophic ulcerations in patients. Herein, we examine the mechanis...

journal_title：Investigative ophthalmology & visual science

authors： Blanco-Mezquita T,Martinez-Garcia C,Proença R,Zieske JD,Bonini S,Lambiase A,Merayo-Lloves J

更新日期：2013-06-04 00:00:00