Abstract：
:We examined the effects of exercise on diaphragm degeneration and cardiomyopathy in dystrophin-deficient mdx mice. Mdx mice (11 months of age) were exercised (swimming) for 2 months to worsen diaphragm degeneration. Control mdx mice were kept sedentary. Morphological evaluation demonstrated increased fibrosis in the diaphragm of exercised mdx mice (33.3 ± 6.0% area of fibrosis) compared with control mdx mice (20.9 ± 1.7% area of fibrosis). Increased (26%) activity of MMP-2, a marker of fibrosis, was detected in the diaphragms from exercised mdx mice. Morphological evaluation of the heart demonstrated a 45% increase in fibrosis in the right ventricle (8.3 ± 0.6% in sedentary vs. 12.0 ± 0.6% of fibrosis in exercised) and in the left ventricle (35% increase) in the exercised mdx mice. The density of inflammatory cells-degenerating cardiomyocytes increased 95% in the right ventricle (2.3 ± 0.6 in sedentary vs. 4.5 ± 0.8 in exercised) and 71% in the left ventricle (1.4 ± 0.6 sedentary vs. 2.4 ± 0.5 exercised). The levels of both active MMP-2 and the pro-fibrotic factor transforming growth factor beta were elevated in the hearts of exercised compared with sedentary mdx mice. The wall thickness to lumen diameter ratio of the pulmonary trunk was significantly increased in the exercised mdx mice (0.11 ± 0.04 in sedentary vs. 0.28 ± 0.12 in exercised), as was the thickness of the right ventricle wall, which suggests the occurrence of pulmonary hypertension in those animals. It is suggested that diaphragm degeneration is a main contributor to right ventricle dystrophic pathology. These findings may be relevant for future interventional studies for Duchenne muscular dystrophy-associated cardiomyopathy.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Barbin IC,Pereira JA,Bersan Rovere M,de Oliveira Moreira D,Marques MJ,Santo Neto Hdoi
10.1111/joa.12443subject
Has Abstractpub_date
2016-05-01 00:00:00pages
784-91issue
5eissn
0021-8782issn
1469-7580journal_volume
228pub_type
杂志文章abstract：:The distribution of muscle fibres classified on the basis of their content of different myosin heavy chain (MHC) isoforms was analysed in vastus lateralis muscle biopsies of 15 young men (with an average age of 22 y) by correlating immunohistochemistry with specific anti-MHC monoclonal antibodies, myofibrillar ATPase ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19930329.x
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abstract：:Two endocrine cell types were found in the metaplastic epithelium of gall bladders removed for gall stones. The endocrine cell type I resembled the EC (enterochromaffin) cell of the normal stomach mucosa. The homogeneous and electron-dense secretory granules were variable in size and shape and mainly located in the su...
journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12208
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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doi：10.1046/j.1469-7580.1999.19410089.x
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19840481.x
更新日期：2001-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13007
更新日期：2019-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19720177.x
更新日期：2000-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2002.00048.x
更新日期：2002-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:The morphology of the cartilage-marrow interface in chick embryo tibiae has been studied from Day 11 to Day 14. The cartilage-marrow interface did not present a uniform aspect and three different areas could be defined. Most of the interface was lined by fibroblast-like cells, macrophage-like cells and multinucleate g...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12198
更新日期：2015-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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更新日期：2015-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:Literature on the development of the human vagina is abundant; however, contributions concerning the prenatal development of the entire utero-vaginal anlagen (UVA) are rare or carried out in rodents. The primary epithelial characteristics in the adult vagina and uterus are determined during prenatal development and de...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12029
更新日期：2013-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00966.x
更新日期：2008-11-01 00:00:00
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journal_title：Journal of anatomy
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