Abstract:
:Anti-Müllerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal functions. However, the possible extragonadal effects of AMH on the hypothalamic-pituitary-gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH neurons both in mice and humans express the AMH receptor, and that AMH potently activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we show that AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons. Increased LH pulsatility is an important pathophysiological feature in many cases of polycystic ovary syndrome (PCOS), the most common cause of female infertility, in which circulating AMH levels are also often elevated. However, the origin of this dysregulation remains unknown. Our findings raise the intriguing hypothesis that AMH-dependent regulation of GnRH release could be involved in the pathophysiology of fertility and could hold therapeutic potential for treating PCOS.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cimino I,Casoni F,Liu X,Messina A,Parkash J,Jamin SP,Catteau-Jonard S,Collier F,Baroncini M,Dewailly D,Pigny P,Prescott M,Campbell R,Herbison AE,Prevot V,Giacobini Pdoi
10.1038/ncomms10055subject
Has Abstractpub_date
2016-01-12 00:00:00pages
10055issn
2041-1723pii
ncomms10055journal_volume
7pub_type
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