Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop.

Abstract:

:Abnormal cancer antioxidant capacity is considered as a potential mechanism of tumor malignancy. Modulation of oxidative stress status is emerging as an anti-cancer treatment. Our previous studies have found that Nestin-knockdown cells were more sensitive to oxidative stress in non-small cell lung cancer (NSCLC). However, the molecular mechanism by which Nestin protects cells from oxidative damage remains unclear. Here, we identify a feedback loop between Nestin and Nrf2 maintaining the redox homeostasis. Mechanistically, the ESGE motif of Nestin interacts with the Kelch domain of Keap1 and competes with Nrf2 for Keap1 binding, leading to Nrf2 escaping from Keap1-mediated degradation, subsequently promoting antioxidant enzyme generation. Interestingly, we also map that the antioxidant response elements (AREs) in the Nestin promoter are responsible for its induction via Nrf2. Taken together, our results indicate that the Nestin-Keap1-Nrf2 axis regulates cellular redox homeostasis and confers oxidative stress resistance in NSCLC.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wang J,Lu Q,Cai J,Wang Y,Lai X,Qiu Y,Huang Y,Ke Q,Zhang Y,Guan Y,Wu H,Wang Y,Liu X,Shi Y,Zhang K,Wang M,Peng Xiang A

doi

10.1038/s41467-019-12925-9

subject

Has Abstract

pub_date

2019-11-06 00:00:00

pages

5043

issue

1

issn

2041-1723

pii

10.1038/s41467-019-12925-9

journal_volume

10

pub_type

杂志文章
  • Quantum nuclear dynamics in the photophysics of diamondoids.

    abstract::The unusual electronic properties of diamondoids, the nanoscale relatives of diamond, make them attractive for applications ranging from drug delivery to field emission displays. Identifying the fundamental origin of these properties has proven highly challenging, with even the most advanced quantum many-body calculat...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3006

    authors: Patrick CE,Giustino F

    更新日期:2013-01-01 00:00:00

  • Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.

    abstract::The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11838

    authors: Pérez-Medina C,Abdel-Atti D,Tang J,Zhao Y,Fayad ZA,Lewis JS,Mulder WJM,Reiner T

    更新日期:2016-06-20 00:00:00

  • Controllable conversion of quasi-freestanding polymer chains to graphene nanoribbons.

    abstract::In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunne...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14815

    authors: Ma C,Xiao Z,Zhang H,Liang L,Huang J,Lu W,Sumpter BG,Hong K,Bernholc J,Li AP

    更新日期:2017-03-13 00:00:00

  • Polariton condensation in solitonic gap states in a one-dimensional periodic potential.

    abstract::Manipulation of nonlinear waves in artificial periodic structures leads to spectacular spatial features, such as generation of gap solitons or onset of the Mott insulator phase transition. Cavity exciton-polaritons are strongly interacting quasiparticles offering large possibilities for potential optical technologies....

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2760

    authors: Tanese D,Flayac H,Solnyshkov D,Amo A,Lemaître A,Galopin E,Braive R,Senellart P,Sagnes I,Malpuech G,Bloch J

    更新日期:2013-01-01 00:00:00

  • Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.

    abstract::Rabies virus (RABV) causes fatal encephalitis in more than 59,000 people yearly. Upon the bite of an infected animal, the development of clinical disease can be prevented with post-exposure prophylaxis (PEP), which includes the administration of Rabies immunoglobulin (RIG). However, the high cost and limited availabil...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14398-7

    authors: Hellert J,Buchrieser J,Larrous F,Minola A,de Melo GD,Soriaga L,England P,Haouz A,Telenti A,Schwartz O,Corti D,Bourhy H,Rey FA

    更新日期:2020-01-30 00:00:00

  • Myths and reality of HPbI3 in halide perovskite solar cells.

    abstract::All-inorganic perovskites have a special place in halide perovskite family because of their potential for better stability. However, the representative cesium lead iodide (CsPbI3) is metastable and spontaneously converts to the non-perovskite structure at room temperature. Here, we demonstrate that what appears to be ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07204-y

    authors: Ke W,Spanopoulos I,Stoumpos CC,Kanatzidis MG

    更新日期:2018-11-14 00:00:00

  • Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.

    abstract::Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-s...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16566-1

    authors: Ciudad S,Puig E,Botzanowski T,Meigooni M,Arango AS,Do J,Mayzel M,Bayoumi M,Chaignepain S,Maglia G,Cianferani S,Orekhov V,Tajkhorshid E,Bardiaux B,Carulla N

    更新日期:2020-06-15 00:00:00

  • Titania supported synergistic palladium single atoms and nanoparticles for room temperature ketone and aldehydes hydrogenation.

    abstract::Selective reduction of ketone/aldehydes to alcohols is of great importance in green chemistry and chemical engineering. Highly efficient catalysts are still demanded to work under mild conditions, especially at room temperature. Here we present a synergistic function of single-atom palladium (Pd1) and nanoparticles (P...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13941-5

    authors: Kuai L,Chen Z,Liu S,Kan E,Yu N,Ren Y,Fang C,Li X,Li Y,Geng B

    更新日期:2020-01-07 00:00:00

  • NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia.

    abstract::Chronic lymphocytic leukaemia (CLL) is a clonal disorder of mature B cells. Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor stimulation. Up to 10% of CLL patients transform from an indolent s...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00830-y

    authors: Märklin M,Heitmann JS,Fuchs AR,Truckenmüller FM,Gutknecht M,Bugl S,Saur SJ,Lazarus J,Kohlhofer U,Quintanilla-Martinez L,Rammensee HG,Salih HR,Kopp HG,Haap M,Kirschniak A,Kanz L,Rao A,Wirths S,Müller MR

    更新日期:2017-10-02 00:00:00

  • Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible.

    abstract::A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are expressed only when the antibiotic is present and the erythromycin resistance methyltransferase activity is c...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2984

    authors: Gupta P,Sothiselvam S,Vázquez-Laslop N,Mankin AS

    更新日期:2013-01-01 00:00:00

  • A single NaK channel conformation is not enough for non-selective ion conduction.

    abstract::NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. In contrast to previous crystallographic results, we show that the selectivity filter (SF) of NaK in native-like lipid membranes adopts two distinct conformations that are stabilized by either Na...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03179-y

    authors: Shi C,He Y,Hendriks K,de Groot BL,Cai X,Tian C,Lange A,Sun H

    更新日期:2018-02-19 00:00:00

  • Benchmarking monolayer MoS2 and WS2 field-effect transistors.

    abstract::Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20732-w

    authors: Sebastian A,Pendurthi R,Choudhury TH,Redwing JM,Das S

    更新日期:2021-01-29 00:00:00

  • Subsistence strategies in traditional societies distinguish gut microbiomes.

    abstract::Recent studies suggest that gut microbiomes of urban-industrialized societies are different from those of traditional peoples. Here we examine the relationship between lifeways and gut microbiota through taxonomic and functional potential characterization of faecal samples from hunter-gatherer and traditional agricult...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms7505

    authors: Obregon-Tito AJ,Tito RY,Metcalf J,Sankaranarayanan K,Clemente JC,Ursell LK,Zech Xu Z,Van Treuren W,Knight R,Gaffney PM,Spicer P,Lawson P,Marin-Reyes L,Trujillo-Villarroel O,Foster M,Guija-Poma E,Troncoso-Corzo L,Warinne

    更新日期:2015-03-25 00:00:00

  • Changes in the regulation of cortical neurogenesis contribute to encephalization during amniote brain evolution.

    abstract::The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report uniqu...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3206

    authors: Nomura T,Gotoh H,Ono K

    更新日期:2013-01-01 00:00:00

  • Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice.

    abstract::Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integrat...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16065-3

    authors: Srifa W,Kosaric N,Amorin A,Jadi O,Park Y,Mantri S,Camarena J,Gurtner GC,Porteus M

    更新日期:2020-05-18 00:00:00

  • Targeted diversity generation by intraterrestrial archaea and archaeal viruses.

    abstract::In the evolutionary arms race between microbes, their parasites, and their neighbours, the capacity for rapid protein diversification is a potent weapon. Diversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to generate myriad variants of a target gene. Originally discovered in ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms7585

    authors: Paul BG,Bagby SC,Czornyj E,Arambula D,Handa S,Sczyrba A,Ghosh P,Miller JF,Valentine DL

    更新日期:2015-03-23 00:00:00

  • A strategy to discover new organizers identifies a putative heart organizer.

    abstract::Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablatio...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12656

    authors: Anderson C,Khan MAF,Wong F,Solovieva T,Oliveira NMM,Baldock RA,Tickle C,Burt DW,Stern CD

    更新日期:2016-08-25 00:00:00

  • Optical framed knots as information carriers.

    abstract::Modern beam shaping techniques have enabled the generation of optical fields displaying a wealth of structural features, which include three-dimensional topologies such as Möbius, ribbon strips and knots. However, unlike simpler types of structured light, the topological properties of these optical fields have hithert...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18792-z

    authors: Larocque H,D'Errico A,Ferrer-Garcia MF,Carmi A,Cohen E,Karimi E

    更新日期:2020-10-09 00:00:00

  • Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole.

    abstract::The yeast Rab5 homologue, Vps21p, is known to be involved both in the vacuolar protein sorting (VPS) pathway from the trans-Golgi network to the vacuole, and in the endocytic pathway from the plasma membrane to the vacuole. However, the intracellular location at which these two pathways converge remains unclear. In ad...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4498

    authors: Toshima JY,Nishinoaki S,Sato Y,Yamamoto W,Furukawa D,Siekhaus DE,Sawaguchi A,Toshima J

    更新日期:2014-03-25 00:00:00

  • Partially coherent radar unties range resolution from bandwidth limitations.

    abstract::It is widely believed that range resolution, the ability to distinguish between two closely situated targets, depends inversely on the bandwidth of the transmitted radar signal. Here we demonstrate a different type of ranging system, which possesses superior range resolution that is almost completely free of bandwidth...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09380-x

    authors: Komissarov R,Kozlov V,Filonov D,Ginzburg P

    更新日期:2019-03-29 00:00:00

  • Phasor field diffraction based reconstruction for fast non-line-of-sight imaging systems.

    abstract::Non-line-of-sight (NLOS) imaging recovers objects using diffusely reflected indirect light using transient illumination devices in combination with a computational inverse method. While capture systems capable of collecting light from the entire NLOS relay surface can be much more light efficient than single pixel poi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15157-4

    authors: Liu X,Bauer S,Velten A

    更新日期:2020-04-02 00:00:00

  • Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1.

    abstract::Human hnRNP A2/B1 is an RNA-binding protein that plays important roles in many biological processes, including maturation, transport, and metabolism of mRNA, and gene regulation of long noncoding RNAs. hnRNP A2/B1 was reported to control the microRNAs sorting to exosomes and promote primary microRNA processing as a po...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-02770-z

    authors: Wu B,Su S,Patil DP,Liu H,Gan J,Jaffrey SR,Ma J

    更新日期:2018-01-29 00:00:00

  • Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum.

    abstract::Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibre...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12938

    authors: Dhar M,Brenner JM,Sakimura K,Kano M,Nishiyama H

    更新日期:2016-09-21 00:00:00

  • Complex virome in feces from Amerindian children in isolated Amazonian villages.

    abstract::The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contac...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06502-9

    authors: Siqueira JD,Dominguez-Bello MG,Contreras M,Lander O,Caballero-Arias H,Xutao D,Noya-Alarcon O,Delwart E

    更新日期:2018-10-15 00:00:00

  • Oscillatory integration windows in neurons.

    abstract::Oscillatory synchrony among neurons occurs in many species and brain areas, and has been proposed to help neural circuits process information. One hypothesis states that oscillatory input creates cyclic integration windows: specific times in each oscillatory cycle when postsynaptic neurons become especially responsive...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms13808

    authors: Gupta N,Singh SS,Stopfer M

    更新日期:2016-12-15 00:00:00

  • Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

    abstract::We previously reported a disease segregating causal germline mutation in a melanoma family and recurrent somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene. Here we show that the TERT promoter mutations, besides causing an i...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4401

    authors: Heidenreich B,Nagore E,Rachakonda PS,Garcia-Casado Z,Requena C,Traves V,Becker J,Soufir N,Hemminki K,Kumar R

    更新日期:2014-02-26 00:00:00

  • Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination.

    abstract::Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct enantioselective C-H amination to access optically pure N-C atropisomer is still difficult and rare. Here we report a π-π interaction and dual H-bond concerted control s...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-10858-x

    authors: Bai HY,Tan FX,Liu TQ,Zhu GD,Tian JM,Ding TM,Chen ZM,Zhang SY

    更新日期:2019-07-11 00:00:00

  • Plant macrofossil evidence for an early onset of the Holocene summer thermal maximum in northernmost Europe.

    abstract::Holocene summer temperature reconstructions from northern Europe based on sedimentary pollen records suggest an onset of peak summer warmth around 9,000 years ago. However, pollen-based temperature reconstructions are largely driven by changes in the proportions of tree taxa, and thus the early-Holocene warming signal...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms7809

    authors: Väliranta M,Salonen JS,Heikkilä M,Amon L,Helmens K,Klimaschewski A,Kuhry P,Kultti S,Poska A,Shala S,Veski S,Birks HH

    更新日期:2015-04-10 00:00:00

  • Giant regular polyhedra from calixarene carboxylates and uranyl.

    abstract::Self-assembly of large multi-component systems is a common strategy for the bottom-up construction of discrete, well-defined, nanoscopic-sized cages. Icosahedral or pseudospherical viral capsids, built up from hundreds of identical proteins, constitute typical examples of the complexity attained by biological self-ass...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1793

    authors: Pasquale S,Sattin S,Escudero-Adán EC,Martínez-Belmonte M,de Mendoza J

    更新日期:2012-04-17 00:00:00

  • A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.

    abstract::Type I modular polyketide synthases assemble diverse bioactive natural products. Such multienzymes typically use malonyl and methylmalonyl-CoA building blocks for polyketide chain assembly. However, in several cases more exotic alkylmalonyl-CoA extender units are also known to be incorporated. In all examples studied ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms13609

    authors: Ray L,Valentic TR,Miyazawa T,Withall DM,Song L,Milligan JC,Osada H,Takahashi S,Tsai SC,Challis GL

    更新日期:2016-12-21 00:00:00