Abstract:
:There is now strong evidence that early nutrition plays an important role in shaping later physiology. We assessed here whether soy protein concentrate (SPC) or soybean meal (SBM) in early diet would modify zebrafish responses to these products in later life. We fed zebrafish larvae with SPC-, SBM-, or a control-diet for the first 3 days of feeding and then grew all larvae on the control diet up to juveniles. Finally, we assessed the expression in juveniles of genes involved in inflammation/immunity, the breakdown of extracellular matrix, luminal digestion, and intestinal nutrient absorption/trafficking. First feeding SBM had wider, stronger, and more persistent effects on gene expression with respect to SPC. Juveniles fed with SPC at first feeding were more prone to inflammation after refeeding with SPC than fish that never experienced SPC before. Conversely, zebrafish that faced SBM at first feeding were later less responsive to refeeding with SBM through inflammation and had higher expression of markers of peptide absorption and fatty acid transport. Results indicate that some features of inflammation/remodeling, presumably at the intestine, and nutrient absorption/transport in fish can be programmed by early nutrition. These findings sustain the rationale of using zebrafish for depicting molecular mechanisms involved in nutritional programming.
journal_name
Zebrafishjournal_title
Zebrafishauthors
Perera E,Yúfera Mdoi
10.1089/zeb.2015.1131subject
Has Abstractpub_date
2016-02-01 00:00:00pages
61-9issue
1eissn
1545-8547issn
1557-8542journal_volume
13pub_type
杂志文章相关文献
Zebrafish文献大全abstract::The European Zebrafish Principal Investigator Meeting (EZPM) is an ideal forum for group leaders using this fantastic animal model not only to discuss science but also to strengthen their interactions, to push forward technological advances, and to define guidelines for the use of this fish in research. The city of Li...
journal_title:Zebrafish
pub_type:
doi:10.1089/zeb.2016.1364
更新日期:2016-12-01 00:00:00
abstract::Aggression is a key component of the behavioral repertoire of animals that impacts on their Darwinian fitness. The available genetic tools in zebrafish make this species a promising vertebrate neurogenetic model for the study of neural circuits underlying aggressive behavior. For this purpose, a detailed characterizat...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0690
更新日期:2011-06-01 00:00:00
abstract::β-Cells of the islet of Langerhans produce insulin to maintain glucose homeostasis. Self-replication of β-cells is the predominant mode of postnatal β-cell production in mammals, with about 20% of rodent β cells dividing in a 24-hour period. However, replicating β-cells are rare in adults. Induction of self-replicatio...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2012.0816
更新日期:2013-06-01 00:00:00
abstract::Several factors contributed to the discovery of Wnt genes. On the one hand, the development of research tools in mammalian genetics such as mouse strains with high incidence of cancer in 1920-1930s led to discovery of the mouse mammary tumor virus in 1949. This virus in turn was used in 1982 to identify int-1 (Wnt1) i...
journal_title:Zebrafish
pub_type: 历史文章,杂志文章,评审
doi:10.1089/zeb.2008.0532
更新日期:2008-09-01 00:00:00
abstract::We have constructed a low-cost aquatic animal holding system that provides an alternative to expensive, commercially available systems. Our flow-through system is especially useful for programs that are limited in space and funding. The easy assembly and maintenance of the system are advantages for the researchers who...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2006.0501
更新日期:2007-07-01 00:00:00
abstract::Since the use of the zebrafish Danio rerio genetic model organism within the scientific research community continues to grow rapidly, continued procedural refinement to support high-quality, reproducible research and improve animal welfare remains an important focus. As such, anesthesia remains one of the most frequen...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1737
更新日期:2019-10-01 00:00:00
abstract::A study was conducted to preliminarily assess the contribution of the intestinal microflora to biotin supply in zebrafish. Biotin and avidin were added to three isonitrogenous and isocaloric purified diets to provide molar avidin: biotin ratios of 0:0 (basal diet), 0:1 (biotin-supplemented diet), and 120:0. Another di...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0706
更新日期:2011-12-01 00:00:00
abstract::Managing the welfare of laboratory animals is critical to animal health, vital in the understanding of phenotypes created by treatment or genetic alteration and ensures compliance of regulations. Part of an animal welfare assessment is the requirement to record observations, ensuring all those responsible for the anim...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1248
更新日期:2016-07-01 00:00:00
abstract::Mycobacteriosis is a common bacterial infection in laboratory zebrafish caused by several different species and strains of Mycobacterium, including both rapid and slow growers. One control measure used to prevent mycobacterial spread within and between facilities is surface disinfection of eggs. Recent studies have hi...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1229
更新日期:2016-07-01 00:00:00
abstract::A review of some exciting new directions for Xiphophorus research in behavioral ecology and integrative animal behavior is presented. The primary objective of this review is to identify areas of research in this teleost genus that, if studied further, could yield insights into the manifold causes and consequences of d...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2006.3.287
更新日期:2006-01-01 00:00:00
abstract::Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1321
更新日期:2017-02-01 00:00:00
abstract::The second European Zebrafish Principal Investigator (PI) Meeting was held in March, 2012, in Karlsruhe, Germany. It brought together PIs from all over Europe who work with fish models such as zebrafish and medaka to discuss their latest results, as well as to resolve strategic issues faced by this research community....
journal_title:Zebrafish
pub_type:
doi:10.1089/zeb.2012.0829
更新日期:2013-03-01 00:00:00
abstract::The family Cichlidae is one of the most species-rich taxa in the Neotropics. However, the factors that determine these high levels of biodiversity remain unexplored. We have analyzed the morphological, cytogenetic, and molecular data from 62 specimens of a widespread cichlid, Geophagus brasiliensis, from three adjacen...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2014.0999
更新日期:2015-02-01 00:00:00
abstract::Dr. Zhiyuan Gong is Associate Professor in the Department of Biological Sciences, National University of Singapore. He graduated with a B.Sc. degree in marine biology from Ocean University of China and received his Ph.D. degree in developmental biology from McGill University in Canada. He spent many years at the Unive...
journal_title:Zebrafish
pub_type: 面试
doi:10.1089/zeb.2004.1.185
更新日期:2004-01-01 00:00:00
abstract::Spring viremia of carp virus (SVCV) causes the skin hemorrhagic disease in cyprinid species, but its molecular mechanism of skin immune response remains unclear at the protein level. In the present study, the differential proteomics of the zebrafish (Danio rerio) skin in response to SVCV infection were examined by iso...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1843
更新日期:2020-04-01 00:00:00
abstract::Microcystin-leucine arginine (MC-LR) is a natural toxin produced by cyanobacterial blooms that causes severe liver damage in fish. It is crucial to investigate if housekeeping genes are affected by MC-LR in zebrafish, to permit the adequate evaluation of gene expression by RT-qPCR. We evaluated the gene expression sta...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1598
更新日期:2018-10-01 00:00:00
abstract::Zebrafish embryos are widely used as a model to monitor the effect of chemicals on their survival and hatching at different time epochs. This experimental design generates longitudinal data in which the observations for a given subject are correlated and they are statistically independent across the subjects. This par...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2013.0921
更新日期:2014-08-01 00:00:00
abstract::Despite the broad repertoire of loss of function (LOF) tools available for use in the zebrafish, there remains a need for a simple and rapid method that can inhibit expression of genes at later stages. RNAi would fulfill that role, and a previous report (Dong et al. 2009) provided encouraging data. The goal of this st...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2012.0770
更新日期:2012-09-01 00:00:00
abstract::The genetic compensation response (GCR), triggered by deleterious mutations but not by gene knockdown, has been proposed to explain many phenotypic discrepancies between gene-knockout and gene-knockdown models. GCRs have been observed in many model organisms from mice to Arabidopsis. Although the GCR is beneficial for...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2019.1824
更新日期:2020-05-20 00:00:00
abstract::The Johns Hopkins Clinical Compound Library (JHCCL), a collection of Food and Drug Administration (FDA)-approved small molecules (1400), was screened in silico for identification of novel β2AR blockers and tested for hematopoietic stem cell (HSC) expansion and radioprotection in zebrafish embryos. Docking studies, fol...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2014.0992
更新日期:2015-02-01 00:00:00
abstract::Although zebrafish is used as a major model species for understanding a number of biological functions and mechanisms involved, there is practically no information on the nutritional requirements of this cyprinid. The rearing practices, especially with regard to feeds and feeding, also vary considerably. To obtain bas...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0696
更新日期:2011-06-01 00:00:00
abstract::Analysis of genes compromising the glomerular filtration barrier in rodent models using transgenic or knockdown approaches is time- and resource-consuming and often leads to unsatisfactory results. Therefore, it would be beneficial to have a selection tool indicating that your gene of interest is in fact associated wi...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1093
更新日期:2015-10-01 00:00:00
abstract::With worldwide rates of obesity and type-II diabetes increasing, it is essential to identify and understand the mechanisms involved during nutrient absorption and fuel allocation. Recent studies demonstrate that nutrients (e.g., lipids and carbohydrates) play a major regulatory role in gene transcription of glycolytic...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0702
更新日期:2011-09-01 00:00:00
abstract::For many years, zebrafish have been the prototypical model for studies in developmental biology. In recent years, zebrafish has emerged as a powerful model system to study infectious diseases, including viral infections. Experiments conducted with herpes simplex virus type-1 in adult zebrafish or in embryo models are ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2013.0920
更新日期:2014-02-01 00:00:00
abstract::We have shown that zebrafish (Danio rerio) are an excellent model for evaluating the link between early life stage exposure to environmental chemicals and disease in adulthood and subsequent unexposed generations. Previously, we used this model to identify transgenerational effects of dioxin (2,3,7,8-tetrachlorodibenz...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2016.1275
更新日期:2016-10-01 00:00:00
abstract::Our first Zebrafish Enhancer TRAP lines database (ZETRAP) generated a few years ago was a web-based system informing the scientific community about the developmental, genetic, and genomic aspects of transgenic zebrafish lines expressing the cytosolic version of EGFP. These transgenic lines were obtained in a primary s...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2011.0718
更新日期:2011-12-01 00:00:00
abstract::Astyanax is a genus with a wide distribution ranging from the south United States to north of Patagonia (Argentina). The available cytogenetic data on Astyanax indicate a high karyotypic diversity, with diploid number of 36-52 chromosomes, presence of B chromosomes, heterochromatin polymorphism, and variations with re...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2018.1647
更新日期:2019-02-01 00:00:00
abstract::The Cannabis sativa plant contains numerous phytocannabinoids and terpenes with known or potential biological activity. For decades, plant breeders have been breeding the Cannabis plant to control for a desired ratio of the major cannabinoids. A high-throughput in vivo model to understand the relationship between the ...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2017.1541
更新日期:2018-08-01 00:00:00
abstract::Zebrafish are increasingly used in neurobiological and behavioral studies. Possible stimuli to manipulate zebrafish behavior are being investigated. The presentation of colors appears to be one of the most used approaches, but there is much debate about the exact color preference. Here we have investigated the color p...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1150
更新日期:2016-08-01 00:00:00
abstract::Spatiotemporal regulation of DNA replication in the S-phase nucleus has been extensively studied in mammalian cells because it is tightly coupled with the regulation of other nuclear processes such as transcription. However, little is known about the replication dynamics in nonmammalian cells. Here, we analyzed the DN...
journal_title:Zebrafish
pub_type: 杂志文章
doi:10.1089/zeb.2015.1151
更新日期:2015-12-01 00:00:00