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The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice.

Abstract：

:Our previous study indicated that the combination of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1), the main components of Salvia miltiorrhizae and Panax notoginseng, improves myocardium structure and ventricular function in rats with ischemia/reperfusion injury. The present study aimed to determine the safety of the combined SalB and Rg1 (SalB-Rg1) in mice. The safety of SalB-Rg1 was evaluated through acute toxicity and repeated-dose toxicity. In the acute toxicity study, the up and down procedure was carried out firstly, and then, the Bliss method was applied. In the toxicity study for seven-day repeated treatment of SalB-Rg1, forty Kunming mice were randomly divided into four groups. The intravenous median lethal dose (LD50) of the SalB-Rg1 combination was 1747 mg/kg using the Bliss method. For both the acute toxicity study and the seven-day repeated toxicity study, SalB-Rg1 did not induce significant abnormality on brain, heart, kidney, liver and lung structure at any dose based on H&E stain. There were no significant changes related to the SalB-Rg1 toxicity detected on biochemical parameters for two kinds of toxicity studies. The LD50 in mice was 1747 mg/kg, which was more than one hundred times higher than the effective dose. Both studies of acute toxicity and seven-day repeated dose toxicity indicated the safety of the SalB-Rg1 combination.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Zhao Q,Yang M,Deng Y,Yu H,Wang L,Teng F,Cho K,Ma H,Wu P,Li X,Wu W,Liu X,Xu F,Jiang B,Guo DA

doi

10.3390/ijms161226176

subject

Has Abstract

pub_date

2015-12-09 00:00:00

pages

29345-56

issue

12

issn

1422-0067

pii

ijms161226176

journal_volume

16

pub_type

杂志文章

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