Abstract:
:A complex antioxidant system has been developed in mammals to relieve oxidative stress. However, excessive reactive species derived from oxygen and nitrogen may still lead to oxidative damage to tissue and organs. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression of liver injury. A lot of risk factors, including alcohol, drugs, environmental pollutants and irradiation, may induce oxidative stress in liver, which in turn results in severe liver diseases, such as alcoholic liver disease and non-alcoholic steatohepatitis. Application of antioxidants signifies a rational curative strategy to prevent and cure liver diseases involving oxidative stress. Although conclusions drawn from clinical studies remain uncertain, animal studies have revealed the promising in vivo therapeutic effect of antioxidants on liver diseases. Natural antioxidants contained in edible or medicinal plants often possess strong antioxidant and free radical scavenging abilities as well as anti-inflammatory action, which are also supposed to be the basis of other bioactivities and health benefits. In this review, PubMed was extensively searched for literature research. The keywords for searching oxidative stress were free radicals, reactive oxygen, nitrogen species, anti-oxidative therapy, Chinese medicines, natural products, antioxidants and liver diseases. The literature, including ours, with studies on oxidative stress and anti-oxidative therapy in liver diseases were the focus. Various factors that cause oxidative stress in liver and effects of antioxidants in the prevention and treatment of liver diseases were summarized, questioned, and discussed.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Li S,Tan HY,Wang N,Zhang ZJ,Lao L,Wong CW,Feng Ydoi
10.3390/ijms161125942subject
Has Abstractpub_date
2015-11-02 00:00:00pages
26087-124issue
11issn
1422-0067pii
ijms161125942journal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:This study aims to investigate: (a) the putative association between the presence of microcalcifications and the expression of both epithelial-to-mesenchymal transition and bone biomarkers, (b) the role of microcalcifications in the breast osteoblast-like cells (BOLCs) formation, and (c) the association betw...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2013-01-14 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2019-02-13 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms19041001
更新日期:2018-03-27 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19092630
更新日期:2018-09-05 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21197267
更新日期:2020-10-01 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2013-09-12 00:00:00
abstract::n/a. ...
journal_title:International journal of molecular sciences
pub_type: 评论,杂志文章
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更新日期:2017-05-05 00:00:00
abstract::Variegated plants are valuable materials for investigating leaf color regulated mechanisms. To unveil the role of posttranslational modification in the variegated phenotype, we conducted global quantitative phosphoproteomic analysis on different leaf color sectors of Maiyuanjinqiu and the corresponding of Catalpa farg...
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abstract::The phylum Thermotogae is composed of a single class (Thermotogae), 4 orders (Thermotogales, Kosmotogales, Petrotogales, Mesoaciditogales), 5 families (Thermatogaceae, Fervidobacteriaceae, Kosmotogaceae, Petrotogaceae, Mesoaciditogaceae), and 13 genera. They have been isolated from extremely hot environments whose cha...
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