Abstract：
:Growing evidence indicates that nomogram combined with the biomarkers of systemic inflammation response could provide more accurate prediction than conventional staging systems in tumors. This study aimed to establish an effective prognostic nomogram for resectable thoracic esophageal squamous cell carcinoma (ESCC) based on the clinicopathological parameters and inflammation-based prognostic scores. We retrospectively investigated 916 ESCC patients who underwent radical esophagectomy. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve, and compared with the 6(th) and 7(th) AJCC TNM classifications. The neutrophil lymphocyte ratio (NLR), C-reactive protein albumin (CRP/Alb) ratio, histological grade, T stage and modified N stage were integrated in the nomogram. The C-index of the nomogram for predicting the survival was 0.72, which showed better predictive ability of OS than the 6(th) or 7(th) TNM stages in the primary cohort (P < 0.001). The calibration curve showed high consistency between the nomogram and actual observation. The decision curve analysis showed more potential of clinical application of the prediction models compared with TNM staging system. Moreover, our findings were supported by the validation cohort. The proposed nomogram showed more accurate prognostic prediction for patients with ESCC after radical esophagectomy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shao Y,Ning Z,Chen J,Geng Y,Gu W,Huang J,Pei H,Shen Y,Jiang Jdoi
10.1038/srep18811subject
Has Abstractpub_date
2015-12-22 00:00:00pages
18811issn
2045-2322pii
srep18811journal_volume
5pub_type
杂志文章abstract：:Metformin is used to treat type 2 diabetes. Metformin activates AMP-activated kinase (AMPK), which may contribute to the action of metformin. Metformin also shows anti-proliferation activity. However, the mechanism is remained unknown. We found that treatment of MCF-7 cells with metformin induced the demethylase activ...
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abstract：:Interfacial Dzyaloshinskii-Moriya interaction (IDMI) is important for its roles in stabilizing the skyrmionic lattice as well as soliton-like domain wall motion leading towards new generation spintronic devices. However, achievement and detection of IDMI is often hindered by various spurious effects. Here, we demonstr...
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更新日期：2016-09-02 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-11-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-02-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-12-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-05 00:00:00
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更新日期：2019-10-23 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-04-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-04-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
