Abstract:
:While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which causes long-lasting side effects. Identification of molecules controlling drug resistance in T-ALL is crucial for treatment optimisation in both scenarios. We report here the EphB6 receptor is frequently overexpressed in T-ALL. Remarkably, our observations indicate that EphB6 acts in T-ALL cells to enhance sensitivity to a DNA-damaging drug, doxorubicin, as interruption of EphB6 activity interferes with the efficiency of doxorubicin-induced eradication of T-ALL cells in cell culture and in xenograft animals. This effect relies on the protection of Akt kinase signaling, while Akt inhibition combined with doxorubicin application produces synergistic effects on the elimination of EphB6-deficient T-ALL cells. These data imply that EphB6 suppresses T-ALL resistance by interfering with Akt activity. Our observations highlight a novel role for EphB6 in reducing drug resistance of T-ALL and suggest that doxorubicin treatment should produce better results if personalised based on EphB6 levels. If successfully verified in clinical studies, this approach should improve outcomes for T-ALL patients resistant to current therapies and for patients, who are being overtreated.
journal_name
Sci Repjournal_title
Scientific reportsauthors
El Zawily A,McEwen E,Toosi B,Vizeacoumar FS,Freywald T,Vizeacoumar FJ,Freywald Adoi
10.1038/s41598-017-15200-3subject
Has Abstractpub_date
2017-11-07 00:00:00pages
14767issue
1issn
2045-2322pii
10.1038/s41598-017-15200-3journal_volume
7pub_type
杂志文章abstract::The current study aims at characterizing the mechanisms that allow humans to entrain the mind and body to incoming rhythmic sensory inputs in real time. We addressed this unresolved issue by examining the relationship between covert neural processes and overt behavior in the context of musical rhythm. We measured temp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20612
更新日期:2016-02-05 00:00:00
abstract::Although microbes influence plant growth, little is known about the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil nutrient dynamics in the context of biodiversity-ecosystem functioning (BEF) research. The BEF theory states that higher species richness can enhance ecosy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72516-3
更新日期:2020-09-22 00:00:00
abstract::Network robustness represents the ability of networks to withstand failures and perturbations. In social networks, maintenance of individual activities, also called persistence, is significant towards understanding robustness. Previous works usually consider persistence on pre-generated network structures; while in so...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42956
更新日期:2017-02-21 00:00:00
abstract::The present study aimed to explore a new source of montmorillonite and to develop an extraction and purification protocol for its isolation from raw clay samples acquired from the Koh-e-Suleiman mountain range in Pakistan. The process involved the collection of raw clay from the source, identification and quantificati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57511-y
更新日期:2020-01-17 00:00:00
abstract::Marine blue holes are precious geological heritages with high scientific research values. Their physical and chemical characteristics are unique because of the steep-walled structure and isolated water column which create isolated ecosystems in geographically restricted areas. The Sansha Yongle Blue Hole (SYBH) is the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67221-0
更新日期:2020-06-24 00:00:00
abstract::Anthracnose caused by Colletotrichum is one of the most severe diseases of Hevea brasiliensis. However, research on the diversity and geographical distribution of Colletotrichum remains limited in China. In this study, we investigated the phylogenetic diversity of Colletotrichum isolates associated with symptomatic ti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28166-7
更新日期:2018-07-11 00:00:00
abstract::Today's electronic devices are fabricated using highly toxic materials and processes which limits their applications in environmental sensing applications and mandates complex encapsulation methods in biological and medical applications. This paper proposes a fully resorbable high density bio-compatible and environmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15395-5
更新日期:2017-11-07 00:00:00
abstract::Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01774
更新日期:2013-01-01 00:00:00
abstract::In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to a delicate balance betwe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16567
更新日期:2015-11-16 00:00:00
abstract::Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18380
更新日期:2015-12-18 00:00:00
abstract::Because of the critical role of transportation in modern times, one of the most successful application areas of statistical physics of complex networks is the study of traffic dynamics. However, the vast majority of works treat transportation networks as an isolated system, which is inconsistent with the fact that man...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19059
更新日期:2016-01-21 00:00:00
abstract::To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that resulted in steatosis. Here we show time-of-day specific changes in expression of clock genes and clock-controlled genes, including those associa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03725
更新日期:2014-01-16 00:00:00
abstract::This study analyzed hourly mass concentration observations of PM2.5 (particulate matters with diameter less than 2.5 μm) at 512 stations in China from December 2013 to May 2015. We found that the mean concentrations of PM2.5 during the winter and spring of 2015 Dec. 2014 to Feb. 2015 and Mar. 2015 to May 2015) decreas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36404
更新日期:2016-11-02 00:00:00
abstract::The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09124-1
更新日期:2017-08-17 00:00:00
abstract::Vδ2 γδ (Vδ2) T cells, a major human γδ T cell subset, exhibit broad anti-tumor and anti-infective activity; however, their precise role in chronic hepatitis C virus (HCV) infections remains unclear. In this study, we analyzed the phenotype and function of Vδ2 T cells in 43 HCV-infected patients compared to 39 healthy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26296
更新日期:2016-05-19 00:00:00
abstract::We performed two phase I trials of the histone deacetylase inhibitor vorinostat combined with either the vascular endothelial growth factor inhibitor pazopanib (NCT01339871) or the proteasome inhibitor ixazomib (NCT02042989) in patients with metastatic TP53 mutant solid tumors. Both trials followed a 3 + 3 dose-escala...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58366-z
更新日期:2020-02-20 00:00:00
abstract::Non-forest ecosystems (predominant in semi-arid and arid regions) contribute significantly to the increasing trend and interannual variation of land carbon uptake over the last three decades, yet the mechanisms are poorly understood. By analysing the flux measurements from 23 ecosystems in Australia, we found the the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11063-w
更新日期:2017-09-15 00:00:00
abstract::A novel process to control light through the coupling modulation by surface acoustic wave (SAW) is presented in an optical micro resonator. An optical waveguide modulator of a racetrack resonator on silicon-on-insulator (SOI) technology is took as an example to explore the mechanism. A finite-difference time-domain (F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30681
更新日期:2016-08-03 00:00:00
abstract::Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs. These events were enriched in seed sequence (73.33%), which was not obser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02397-6
更新日期:2017-05-26 00:00:00
abstract::Heterostructures consisting of two-dimensional materials have shown new physical phenomena, novel electronic and optical properties, and new device concepts not observed in bulk material systems or purely three dimensional heterostructures. These new effects originated mostly from the van der Waals interaction between...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14374
更新日期:2015-09-23 00:00:00
abstract::The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on the growth of Bradyrhizobium liaoningense CCBAU05525 and its nodulation on soybean. Results showed that WSHM ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10836
更新日期:2015-06-08 00:00:00
abstract::Among atrial fibrillation (AF) patients, Danish nationwide registries (2011-2015) were used to examine temporal trends of initiation patterns of oral anticoagulation (OAC) treatment according to age. Overall, 43,299 AF patients initiating vitamin K antagonists (VKA) (42%), dabigatran (29%), rivaroxaban (13%), or apixa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31477
更新日期:2016-08-11 00:00:00
abstract::Laparoscopic cholecystectomy (LC) is the standard technique for treatment of gallbladder disease. In case of acute cholecystitis we can identify preoperative factors associated with an increased risk of conversion and intraoperative complications. The aim of our study was to detect preoperative laboratory and radiolog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81938-6
更新日期:2021-01-28 00:00:00
abstract::Objectum-sexuality (OS) is a sexual orientation which has received little attention in the academic literature. Individuals who identify as OS experience emotional, romantic and/or sexual feelings towards inanimate objects (e.g. a bridge, a statue). We tested 34 OS individuals and 88 controls, and provide the first em...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56449-0
更新日期:2019-12-27 00:00:00
abstract::Chemical purity of RNA samples is important for high-precision studies of RNA folding and catalytic behavior, but photodamage accrued during ultraviolet (UV) shadowing steps of sample preparation can reduce this purity. Here, we report the quantitation of UV-induced damage by using reverse transcription and single-nuc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00517
更新日期:2012-01-01 00:00:00
abstract::Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10008-7
更新日期:2017-08-24 00:00:00
abstract::The migration of oligodendrocyte progenitor cells (OPCs) to the white matter is an indispensable requirement for an intact brain function. The mechanism of cell migration in general is not yet completely understood. Nevertheless, evidence is accumulating that besides the coordinated rearrangement of the cytoskeleton, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01806
更新日期:2013-01-01 00:00:00
abstract::Although geological and modelling evidence indicate that the last glacial inception in North America was in NE Canada, little is known about the glacial response of the nearby western Greenland Ice Sheet (GIS) during the glacial advance of marine oxygen isotope stage 4 (MIS4). Our multi-proxy study of a marine sedimen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51983-3
更新日期:2019-10-30 00:00:00
abstract::Betel quid is one of the most widely used psychoactive substances, and is consumed by approximately 10% of the world's population. In addition to its carcinogenicity, betel quid has also been reported to affect many organs, including the brain, heart, lungs, gastrointestinal tract, and reproductive organs. As betel qu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49815-5
更新日期:2019-10-10 00:00:00
abstract::Power induced wave collapse is one of the most fascinating phenomena in optics as it provides extremely high intensities, thus stimulating a range of nonlinear processes. For low power levels, propagation of beams in bulk media is dominated by diffraction, while above a certain threshold self-focusing is steadily enha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46060-8
更新日期:2019-07-02 00:00:00