Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease.

abstract：AIM:To determine if liver stiffness (LS) measurements by means of transient elastography (TE) correlate with the presence of significant esophageal varices (EV) and if they can predict the occurrence of variceal bleeding. METHODS:We studied 1000 cases of liver cirrhosis divided into 2 groups: patients without EV or wi...

journal_title：World journal of gastroenterology

authors： Sporea I,Raţiu I,Sirli R,Popescu A,Bota S

更新日期：2011-05-07 00:00:00

abstract：:Hepatitis B virus (HBV) and hepatitis C virus (HCV) share common mode of transmission and both are able to induce a chronic infection. Dual HBV/HCV chronic coinfection is a fairly frequent occurrence, especially in high endemic areas and among individuals at high risk of parenterally transmitted infections. The intrac...

journal_title：World journal of gastroenterology

authors： Caccamo G,Saffioti F,Raimondo G

更新日期：2014-10-28 00:00:00

abstract：AIM:To investigate functional change of dendritic cells (DCs) derived from allogeneic partial liver graft undergoing acute rejection in rats. METHODS:Allogeneic (SD rat to LEW rat) whole and 50 % partial liver transplantation were performed. DCs from liver grafts 0 hr and 4 days after transplantation were isolated and...

journal_title：World journal of gastroenterology

authors： Xu MQ,Yao ZX

更新日期：2003-01-01 00:00:00

abstract：AIM:To investigate the effects of osteopontin (OPN) gene expression knockdown on colon cancer Lovo cells in vitro. METHODS:Four candidate small interfering RNA (siRNA) constructs targeting the OPN gene and a scrambled control sequence (NC-siRNA) were synthesized and inserted into a pGPU6/GFP/Neo expression vector. Aft...

journal_title：World journal of gastroenterology

authors： Wu XL,Lin KJ,Bai AP,Wang WX,Meng XK,Su XL,Hou MX,Dong PD,Zhang JJ,Wang ZY,Shi L

更新日期：2014-08-14 00:00:00

abstract：:This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma. The bleeding was stopped by selective embolization of right hepatic artery branches. Subsequently, partial hepatectomy was performed afte...

journal_title：World journal of gastroenterology

authors： Huurman VA,Stoot JH,van der Linden E,Terpstra OT,Schaapherder AF

更新日期：2006-10-07 00:00:00

abstract：:A 53-year-old male patient with a large hydatid cyst of the left hemidiaphragm and smaller secondary cysts located in the left thoracic cavity and upper left abdominal quadrant presented with two progressively enlarging lipoma-like masses in the left hypochondrium and under the left scapulae respectively. Total excisi...

journal_title：World journal of gastroenterology

authors： Marinis A,Fragulidis G,Karapanos K,Konstantinidis C,Brestas P,Vassiliou J,Smyrniotis V

更新日期：2006-11-28 00:00:00

abstract：:The anti-tumor necrosis factor (TNF)alpha medications demonstrate efficacy in the induction of remission and its maintenance in numerous chronic inflammatory conditions. With the increasing number of patients receiving anti-TNFalpha agents, however, less common adverse reactions will occur. Cutaneous eruptions complic...

journal_title：World journal of gastroenterology

authors： Salama M,Lawrance IC

更新日期：2009-09-21 00:00:00

abstract：AIM:To explore molecular mechanism of nicotinamide adenine dinucleotide (NADH) antagonization against X-ray induced L02 cells damage. METHODS:L02 liver cells were cultured in RPMI 1640, exposed to X-ray irradiation and continued to culture in the presence or absence of NADH. Cellular viability was analyzed by routine ...

journal_title：World journal of gastroenterology

authors： Liu FQ,Zhang JR

更新日期：2003-08-01 00:00:00

abstract：AIM:To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS:After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type I),...

journal_title：World journal of gastroenterology

authors： Ewald N,Marzeion AM,Bretzel RG,Kloer HU,Hardt PD

更新日期：2007-02-14 00:00:00

abstract：AIM:To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats. METHODS:Gastric mucosal injury was induced in male Hos:Donryu rats by oral administration of indomethacin at a dose of 48 mg/kg. One hour before in...

journal_title：World journal of gastroenterology

authors： Zhang X,Tajima K,Kageyama K,Kyoi T

更新日期：2008-08-14 00:00:00

abstract：AIM:To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS:Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanofor...

journal_title：World journal of gastroenterology

authors： Dianzani C,Foglietta F,Ferrara B,Rosa AC,Muntoni E,Gasco P,Della Pepa C,Canaparo R,Serpe L

更新日期：2017-06-21 00:00:00

abstract：:The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence...

journal_title：World journal of gastroenterology

authors： Babickova J,Gardlik R

更新日期：2015-10-28 00:00:00

abstract：AIM:To explore the relationship among interferon-gamma (IFN-gamma) activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity. METHODS:Peripheral blood samples from a total of 43 hepatitis B cirrhotic patients (LC) and 19 healthy controls (NC) were collected to measure their serum levels of IFN-...

journal_title：World journal of gastroenterology

authors： Tang JT,Fang JY,Gu WQ,Li EL

更新日期：2006-05-21 00:00:00

abstract：AIM:To determine the incidence of Epstein Barr virus associated gastric carcinoma (GC) in Brazil and compare the expressions of apoptosis related proteins and nitric oxide synthases between EBV positive and negative gastric carcinoma. METHODS:In situ hybridization of EBV-encoded small RNA-1 (EBER-1) and PCR was perfor...

journal_title：World journal of gastroenterology

authors： Begnami MD,Montagnini AL,Vettore AL,Nonogaki S,Brait M,Simoes-Sato AY,Seixas AQ,Soares FA

更新日期：2006-08-21 00:00:00

abstract：AIM:To evaluate the effects of combined radiofrequency ablation and transcatheter arterial embolization with iodized oil on ablation time, maximum output, coagulation diameter, and portal angiography in a porcine liver model. METHODS:Radiofrequency ablation (RFA) was applied to in vivo livers of 10 normal pigs using a...

journal_title：World journal of gastroenterology

authors： Nakai M,Sato M,Sahara S,Kawai N,Tanihata H,Kimura M,Terada M

更新日期：2007-05-28 00:00:00

abstract：AIM:To study the differential protein profile in serum of hepatitis B patients. METHODS:Serum samples were obtained from patients with chronic hepatitis B who were receiving peginterferon alfa-2b. The serum samples were subjected to albumin depletion and analyzed by two-dimensional gel electrophoresis (2-DE). Differen...

journal_title：World journal of gastroenterology

authors： Kuakarn S,SomParn P,Tangkijvanich P,Mahachai V,Thongboonkerd V,Hirankarn N

更新日期：2013-08-21 00:00:00

abstract：:Multiple pathogenic mechanisms have been implicated in autoimmune hepatitis, but they have not fully explained susceptibility, triggering events, and maintenance or escalation of the disease. Furthermore, they have not identified a critical defect that can be targeted. The goals of this review are to examine the diver...

journal_title：World journal of gastroenterology

authors： Czaja AJ

更新日期：2019-12-07 00:00:00

abstract：AIM:To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS:From September 2003 to January 2004, we perfo...

journal_title：World journal of gastroenterology

authors： Cho YK,Choi MG,Park JM,Oh JH,Paik CN,Lee JW,Lee IS,Kim SW,Chung IS

更新日期：2006-10-21 00:00:00

abstract：AIM:To investigate the apoptotic effect of photoexcited titanium dioxide (TiO(2)) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS:Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human...

journal_title：World journal of gastroenterology

authors： Wang L,Mao J,Zhang GH,Tu MJ

更新日期：2007-08-07 00:00:00

abstract：:Because of the low prevalence of non-ampullary duodenal epithelial tumors (NADETs), standardized clinical management of sporadic superficial NADETs, including diagnosis, treatment, and follow-up, has not yet been established. Retrospective studies have revealed certain endoscopic findings suggestive of malignancy. Duo...

journal_title：World journal of gastroenterology

authors： Kakushima N,Kanemoto H,Tanaka M,Takizawa K,Ono H

更新日期：2014-09-21 00:00:00

abstract：AIM:To assess intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for monitoring early efficacy of chemotherapy in a human gastric cancer mouse model. METHODS:IVIM-DWI was performed with 12 b-values (0-800 s/mm(2)) in 25 human gastric cancer-bearing nude mice at baseline (day 0), and then they were rand...

journal_title：World journal of gastroenterology

authors： Song XL,Kang HK,Jeong GW,Ahn KY,Jeong YY,Kang YJ,Cho HJ,Moon CM

更新日期：2016-06-28 00:00:00

abstract：AIM:To investigate serum mean platelet volume (MPV) levels in acute pancreatitis (AP) patients and assess whether MPV effectively predicts the disease severity of AP. METHODS:We included 117 consecutive patients with AP as the AP group and 34 consecutive patients with colorectal polyps (before endoscopic treatment) as...

journal_title：World journal of gastroenterology

authors： Lei JJ,Zhou L,Liu Q,Xiong C,Xu CF

更新日期：2017-04-07 00:00:00

abstract：AIM:To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS:Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were d...

journal_title：World journal of gastroenterology

authors： Shi LH,Zhu XQ,Zhao GH,Xia YB,Zhang YS

更新日期：2006-10-21 00:00:00

abstract：:Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Most evidence points towards screening with fecal occult blood testing. The immunochemical fecal occult blood te...

journal_title：World journal of gastroenterology

authors： McLoughlin RM,O'Morain CA

更新日期：2006-11-14 00:00:00

abstract：:A 55-year old male patient was diagnosed with strongy-loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life-threatening gastrointestinal (GI) bleeding. Repeate...

journal_title：World journal of gastroenterology

authors： Csermely L,Jaafar H,Kristensen J,Castella A,Gorka W,Chebli AA,Trab F,Alizadeh H,Hunyady B

更新日期：2006-10-21 00:00:00

abstract：AIM:To investigate serum insulin-like growth factor-binding protein 5 (IGFBP-5) levels and intestinal IGFBP-5 expression in patients with Crohn's disease (CD). METHODS:We analyzed the serum concentrations and intestinal expression of IGFBP-5 in 42 patients with CD, of whom 26 had endoscopically or radiologically prove...

journal_title：World journal of gastroenterology

authors： Adali G,Yorulmaz E,Ozkanli S,Ulasoglu C,Bayraktar B,Orhun A,Colak Y,Tuncer I

更新日期：2013-12-21 00:00:00

abstract：:Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepati...

journal_title：World journal of gastroenterology

authors： Paschos KA,Majeed AW,Bird NC

更新日期：2014-04-14 00:00:00

abstract：AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for <2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to study its enzymatic activity...

journal_title：World journal of gastroenterology

authors： Zhuge J,Yu YN,Wu XD

更新日期：2004-01-15 00:00:00

abstract：:Fermented foods have been consumed for centuries across many geographical locales and have traditionally been considered healthy foods, partly because of the live microbes contained in them. The concept of "probiotics" further requires that the microbes be defined and their health effects be demonstrated through human...

journal_title：World journal of gastroenterology

authors： Ebner S,Smug LN,Kneifel W,Salminen SJ,Sanders ME

更新日期：2014-11-21 00:00:00

abstract：:To review the underlying pathophysiology and currently available treatments for pruritis associated with jaundice. English language literature was reviewed using MEDLINE, PubMed, EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jau...

journal_title：World journal of gastroenterology

authors： Bassari R,Koea JB

更新日期：2015-02-07 00:00:00