Abstract：
:Tyramine and histamine, the most toxic biogenic amines (BA), are often found in high concentrations in certain foods. Prompted by the limited knowledge of BA toxicity, and increasing awareness of the risks associated with high intakes of dietary BA, the in vitro cytotoxicity of tyramine and histamine was investigated. Tyramine and histamine were toxic for HT29 intestinal cell cultures at concentrations commonly found in BA-rich food, as determined by real-time cell analysis. Surprisingly, tyramine had a stronger and more rapid cytotoxic effect than histamine. Their mode of action was also different, while tyramine caused cell necrosis, histamine induced apoptosis. To avoid health risks, the BA content of foods should be reduced and legal limits established for tyramine.
journal_name
Food Chemjournal_title
Food chemistryauthors
Linares DM,del Rio B,Redruello B,Ladero V,Martin MC,Fernandez M,Ruas-Madiedo P,Alvarez MAdoi
10.1016/j.foodchem.2015.11.013subject
Has Abstractpub_date
2016-04-15 00:00:00pages
658-63issue
Pt Aeissn
0308-8146issn
1873-7072pii
S0308-8146(15)30158-8journal_volume
197pub_type
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