Abstract:
:The potential health effects of 30 spices, commonly used for daily consumption, were submitted to bioactivity screening with several anti-obesity related bioassays: adenosine A1 receptor binding, cannabinoid CB1 receptor binding, TNF-α and 3T3-L1 adipocytes differentiation induction. Sesame seed and red chilli exhibited high binding activity to the adenosine A1 receptor and nutmeg, mace, black pepper and turmeric to the cannabinoid CB1 receptor, while piment and turmeric showed high inhibition of TNF-α accumulation. Black onion seed proved to be the only spice with high 3T3-L1 adipocyte differentiation induction activity. Several well known major compounds found in these active spices were tested with the respective bioassays but did not show activity. Thus, it appears that other minor compounds or the synergistic effects of different constituents are responsible for the observed activity.
journal_name
Food Chemjournal_title
Food chemistryauthors
Yuliana ND,Iqbal M,Jahangir M,Wijaya CH,Korthout H,Kottenhage M,Kim HK,Verpoorte Rdoi
10.1016/j.foodchem.2010.12.066subject
Has Abstractpub_date
2011-06-15 00:00:00pages
1724-9issue
4eissn
0308-8146issn
1873-7072pii
S0308-8146(10)01687-0journal_volume
126pub_type
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