Screening of selected Asian spices for anti obesity-related bioactivities.

Abstract:

:The potential health effects of 30 spices, commonly used for daily consumption, were submitted to bioactivity screening with several anti-obesity related bioassays: adenosine A1 receptor binding, cannabinoid CB1 receptor binding, TNF-α and 3T3-L1 adipocytes differentiation induction. Sesame seed and red chilli exhibited high binding activity to the adenosine A1 receptor and nutmeg, mace, black pepper and turmeric to the cannabinoid CB1 receptor, while piment and turmeric showed high inhibition of TNF-α accumulation. Black onion seed proved to be the only spice with high 3T3-L1 adipocyte differentiation induction activity. Several well known major compounds found in these active spices were tested with the respective bioassays but did not show activity. Thus, it appears that other minor compounds or the synergistic effects of different constituents are responsible for the observed activity.

journal_name

Food Chem

journal_title

Food chemistry

authors

Yuliana ND,Iqbal M,Jahangir M,Wijaya CH,Korthout H,Kottenhage M,Kim HK,Verpoorte R

doi

10.1016/j.foodchem.2010.12.066

subject

Has Abstract

pub_date

2011-06-15 00:00:00

pages

1724-9

issue

4

eissn

0308-8146

issn

1873-7072

pii

S0308-8146(10)01687-0

journal_volume

126

pub_type

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