Development, validation and application of a LC-MS/MS method for quantification of 15 cannabinoids in food.

Abstract:

:In this study, the occurrence of cannabinoids in hemp-based food products was investigated. For that purpose, a new liquid chromatography tandem mass spectrometry method for the quantification of fifteen cannabinoids was developed and validated for multiple matrices. Method performances were good, fulfilling the SANTE/11813/2017 requirements, and allowing for products compliance testing with various national legislations on cannabinoids levels in food products. The limit of quantification of each analyte was 0.15 mg/kg for hemp seed and hemp protein, 0.6 mg/kg for hemp seed oil, and 0.005 mg/kg for raw milk and milk powder. The applicability of the method was further demonstrated by conducting a limited survey on twenty hemp-based food products. The survey revealed that products from the same category can have very different cannabinoids profiles and levels. These results highlighted the importance of cannabinoids testing of food products in view of the current heterogeneous and fast evolving regulatory landscape worldwide.

journal_name

Food Chem

journal_title

Food chemistry

authors

Christinat N,Savoy MC,Mottier P

doi

10.1016/j.foodchem.2020.126469

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

126469

eissn

0308-8146

issn

1873-7072

pii

S0308-8146(20)30331-9

journal_volume

318

pub_type

杂志文章
  • Effect of acid deamidation-alcalase hydrolysis induced modification on functional and bitter-masking properties of wheat gluten hydrolysates.

    abstract::The low solubility of wheat gluten (WG) considerably limits its application. Owing to its high hydrolytic efficiency, alcalase was the protease selected for the enzymatic hydrolysis of WG. The functional properties of WG hydrolysate prepared by alcalase (AHWG) with a hydrolysis degree (DH) of 10% were better than thos...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2018.11.004

    authors: He W,Yang R,Zhao W

    更新日期:2019-03-30 00:00:00

  • The kinetics of Maillard reaction in lactose-hydrolysed milk powder and related systems containing carbohydrate mixtures.

    abstract::The kinetics of Maillard reaction in lactose-hydrolysed skim milk powder and related systems containing carbohydrate mixtures were analysed. The effect of the increase of water activity and temperature during storage of the commercial product was also evaluated. In systems with two and three carbohydrates, a marked de...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.06.093

    authors: Naranjo GB,Pereyra Gonzales AS,Leiva GE,Malec LS

    更新日期:2013-12-15 00:00:00

  • Near infrared spectroscopy for prediction of antioxidant compounds in the honey.

    abstract::The selection of antioxidant variables in honey is first time considered applying the near infrared (NIR) spectroscopic technique. A total of 60 honey samples were used to develop the calibration models using the modified partial least squares (MPLS) regression method and 15 samples were used for external validation. ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.06.066

    authors: Escuredo O,Seijo MC,Salvador J,González-Martín MI

    更新日期:2013-12-15 00:00:00

  • Glucosinolates redox activities: can they act as antioxidants?

    abstract::Glucosinolates are a class of secondary plant metabolites particularly occurring in Cruciferae with potential health-promoting properties, as their hydrolysis products, isothiocyanates, possess chemopreventive and antioxidant activities. In the present study, we systematically studied the in vitro redox behaviour of 1...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.10.134

    authors: Natella F,Maldini M,Leoni G,Scaccini C

    更新日期:2014-04-15 00:00:00

  • High-yield synthesis of bioactive ethyl cinnamate by enzymatic esterification of cinnamic acid.

    abstract::In this paper, Lipozyme TLIM-catalyzed synthesis of ethyl cinnamate through esterification of cinnamic acid with ethanol was studied. In order to increase the yield of ethyl cinnamate, several media, including acetone, isooctane, DMSO and solvent-free medium, were investigated in this reaction. The reaction showed a h...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.06.017

    authors: Wang Y,Zhang DH,Zhang JY,Chen N,Zhi GY

    更新日期:2016-01-01 00:00:00

  • Isolation of a tyrosinase inhibitor from unripe grapes juice: A spectrophotometric study.

    abstract::Grapes are known to contain high quantity of polyphenolic compounds, including caffeic, coumaric and ferulic acids esterified with tartaric acid, to yield caftaric, coutaric and fertaric acids, respectively. These acids are more abundant in unripe grapes, which can be processed into verjuice, a product that shows intr...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.125506

    authors: Honisch C,Osto A,Dupas de Matos A,Vincenzi S,Ruzza P

    更新日期:2020-02-01 00:00:00

  • The beneficial effects of rutin on myofibrillar protein gel properties and related changes in protein conformation.

    abstract::Effects of different levels of rutin (0, 10, 50, 100 and 200 μmol/g protein) on the conformational changes and gel properties of myofibrillar protein (MP) were investigated. Rutin at 200 μmol/g caused the greatest carbonyl content. The incorporation of rutin caused the losses of thiol, free amine and α-helix contents,...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.125206

    authors: Jia N,Zhang F,Liu Q,Wang L,Lin S,Liu D

    更新日期:2019-12-15 00:00:00

  • Effect of adding different thickening agents on the viscosity properties and in vitro mineral availability of infant formula.

    abstract::The effect of adding different thickening agents (locust bean gum (LBG), modified corn and rice starches (MCS, MRS)) to an infant formula on both in vitro mineral availability (Ca, Fe and Zn), quantified by atomic absorption spectrophotometry (AAS), and formula viscosity, after in vitro gastrointestinal digestion, was...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.02.168

    authors: González-Bermúdez CA,Frontela-Saseta C,López-Nicolás R,Ros-Berruezo G,Martínez-Graciá C

    更新日期:2014-09-15 00:00:00

  • Metal ion interactions with methyl gallate characterized by UV spectroscopic and computational methods.

    abstract::A simple biologically active phenolic methyl gallate (MeG) was used as a model compound to identify the nature of the complexes it formed with Al3+, Fe3+, Cu2+, and Sn2+ as analyzed by ultraviolet (UV) spectroscopic and computational methods. The results showed that, among all the metal ions studied in the present stu...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.04.083

    authors: Zhang L,Liu Y,Hu X,Wang Y,Xu M

    更新日期:2019-09-30 00:00:00

  • Accurate and sensitive determination of lead in black tea samples using cobalt magnetic particles based dispersive solid-phase microextraction prior to slotted quartz tube-flame atomic absorption spectrometry.

    abstract::Newly developed combination of magnetic cobalt particles based dispersive solid-phase microextraction (Co-MP-DSPME) and slotted quartz tube attached flame atomic absorption spectrometry (SQT-FAAS) was utilized to determine lead at trace levels in tea samples. Co-MPs' adsorbent properties were tested and validated for ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.06.014

    authors: Akkaya E,Erulas FA,Büyükpinar Ç,Bakirdere S

    更新日期:2019-11-01 00:00:00

  • In depth study of phenolic profile and PTP-1B inhibitory power of cold-pressed grape seed oils of different varieties.

    abstract::This paper investigates the phenolic composition of 17 monocultivar commercial cold-pressed grape seed oils. Chromatographic profiles showed the presence of more than 28 molecules, 11 of which were successfully identified by HPLC-DAD-MS-TOF and HPLC-FLD analysis. Pinoresinol, ethyl caffeate and ethyl gallate were dete...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2018.07.140

    authors: Cecchi L,Innocenti M,Urciuoli S,Arlorio M,Paoli P,Mulinacci N

    更新日期:2019-01-15 00:00:00

  • Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon.

    abstract::The effect of dietary supplementation with Se-enriched Agaricus bisporus on cytosolic gluthathione peroxidase-1 (GPx-1), gastrointestinal specific glutathione peroxidase-2 (GPx-2), thioredoxin reductase-1 (TrxR-1) and selenoprotein P (SeP) mRNA expression and GPx-1 enzyme activity in rat colon was examined. Rats were ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.09.074

    authors: Maseko T,Howell K,Dunshea FR,Ng K

    更新日期:2014-03-01 00:00:00

  • Automatic determination of nickel in foods by flame atomic absorption spectrometry.

    abstract::A new sensitive and low cost flow injection method that combines acid extraction, preconcentration and flame atomic absorption spectrometric determination of nickel in food samples at μg/g levels is described. The dynamic acid extraction step was carried out by using a continuous ultrasound-assisted extraction system....

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2007.11.019

    authors: Yebra MC,Cancela S,Cespón RM

    更新日期:2008-05-15 00:00:00

  • Quantitative analysis of phenolic compounds in Chinese hawthorn (Crataegus spp.) fruits by high performance liquid chromatography-electrospray ionisation mass spectrometry.

    abstract::Eleven major phenolic compounds (hyperoside, isoquercitrin, chlorogenic acid, ideain, epicatechin, two procyanidin (PA) dimers, three PA trimers and a PA dimer-hexoside) were quantified in the fruits of 22 cultivars/origins of three species of the Chinese hawthorn (Crataegus spp.) by HPLC-ESI-MS-SIR. Hyperoside (0.1-0...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2011.01.103

    authors: Liu P,Kallio H,Lü D,Zhou C,Yang B

    更新日期:2011-08-01 00:00:00

  • Nutritional and physicochemical characteristic of commercial Spanish citrus juices.

    abstract::Citrus juices are perceived as healthy foods by consumers due to their richness in antioxidant compounds. Despite the large number of papers about the antioxidant activity of citrus juices, less is known about the relationship with physicochemical properties. This paper shows that the overall antioxidant activity of c...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.05.047

    authors: Alvarez J,Pastoriza S,Alonso-Olalla R,Delgado-Andrade C,Rufián-Henares JA

    更新日期:2014-12-01 00:00:00

  • Phosphoproteome analysis of sarcoplasmic and myofibrillar proteins in bovine longissimus muscle in response to postmortem electrical stimulation.

    abstract::Protein phosphorylation changes of the sarcoplasmic and myofibrillar proteins in beef longissimus muscle in response to electrical stimulation (ES) was investigated. Sarcoplasmic and myofibrillar proteins purified from muscle samples taken at 0, 3 and 10h after ES were separated on SDS-PAGE and stained with phosphorou...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.11.139

    authors: Li C,Zhou G,Xu X,Lundström K,Karlsson A,Lametsch R

    更新日期:2015-05-15 00:00:00

  • Phenylalanine ammonia-lyase, flavanone 3β-hydroxylase and flavonol synthase enzyme activity by a new in vitro assay method in berry fruits.

    abstract::An HPLC method for the determination of phenylalanine ammonia-lyase, flavanone 3β-hydroxylase and flavonol synthase enzyme activity is proposed. This method is based on the determination of the compounds produced and consumed on the enzymatic reaction in just one chromatographic analysis. Optimisation of the method co...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2013.12.034

    authors: Flores G,De la Peña Moreno F,Blanch GP,Del Castillo ML

    更新日期:2014-06-15 00:00:00

  • Bioactive compounds and antioxidant potential fruit of Ximenia americana L.

    abstract::The caatinga ecoregion in northeast Brazil presents a wide variety in plant species. However, the potential of these species as a source of energy, carbohydrates, vitamins, minerals and bioactive properties beneficial to health is still unknown. Among these species we can find the wild plum (Ximenia americana). Due to...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.07.129

    authors: Almeida ML,Freitas WE,de Morais PL,Sarmento JD,Alves RE

    更新日期:2016-02-01 00:00:00

  • Relationships of damaged starch granules and particle size distribution with pasting and thermal profiles of milled MR263 rice flour.

    abstract::This research was conducted to investigate the effects of different grinding techniques (dry, semi-wet and wet) of milled rice grains on the damaged starch and particle size distribution of flour produced from a new variety, MR263, specifically related to the pasting and thermal profiles. The results indicated that gr...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.05.095

    authors: Asmeda R,Noorlaila A,Norziah MH

    更新日期:2016-01-15 00:00:00

  • iTRAQ-based quantitative proteomics reveals the biochemical mechanism of cold stress adaption of razor clam during controlled freezing-point storage.

    abstract::Razor clam is a major cultivated shellfish of great economic importance and high nutritional value. Due to high corruptible potential, razor clam is generally preserved by controlled freezing-point storage (CFPS). Here, we applied isobaric tags for relative and absolute quantification (iTRAQ) labeling to investigate t...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2017.12.004

    authors: Wang C,Chu J,Fu L,Wang Y,Zhao F,Zhou D

    更新日期:2018-05-01 00:00:00

  • Coupling of ultrafiltration and enzymatic hydrolysis aiming at valorizing shrimp wastewater.

    abstract::The objective of this work was to obtain a protein hydrolysate from the wastewater generated during shrimp cooking, by coupling ultrafiltration and enzymatic hydrolysis processes. Initially, the effluent was concentrated by ultrafiltration, reaching a protein concentration factor of 3.2. The concentrated effluent was ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.11.094

    authors: Tonon RV,dos Santos BA,Couto CC,Mellinger-Silva C,Brígida AI,Cabral LM

    更新日期:2016-05-01 00:00:00

  • Malondialdehyde determination in raw and processed meat products by UPLC-DAD and UPLC-FLD.

    abstract::The objective of this study was to develop an accurate and fast method to determine malondialdehyde (MDA) levels in raw and processed meat. This method is based on extraction with trichloroacetic acid (TCA), reaction with 2-thiobarbituric acid (TBA) and quantification with ultraperformance liquid chromatography with a...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2019.125009

    authors: Bertolín JR,Joy M,Blanco M

    更新日期:2019-11-15 00:00:00

  • γ-Oryzanol and tocopherol contents in residues of rice bran oil refining.

    abstract::Rice bran oil (RBO) contains significant amounts of the natural antioxidants γ-oryzanol and tocopherols, which are lost to a large degree during oil refining. This results in a number of industrial residues with high contents of these phytochemicals. With the aim of supporting the development of profitable industrial ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2012.03.059

    authors: Pestana-Bauer VR,Zambiazi RC,Mendonça CR,Beneito-Cambra M,Ramis-Ramos G

    更新日期:2012-10-01 00:00:00

  • Development of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of hen's egg white allergens Gal d 1-4 in fresh and processed eggs.

    abstract::Hen's egg white allergens, namely Gal d 1-4, cause food allergies worldwide and their intake must be strictly controlled by allergic individuals. However, an efficient method for quantifying these allergens is currently unavailable. We aimed to develop an LC-MS/MS method for simultaneous Gal d 1-4 quantification. Puri...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2020.128022

    authors: Kiyota K,Yoshimitsu M,Uchida K,Kajimura K

    更新日期:2020-09-06 00:00:00

  • The effect of vacuum frying on starch gelatinization and its in vitro digestibility in starch-gluten matrices.

    abstract::Starch digestibility in a food matrix depends on processing conditions that may affect its physical state and microstructure. Starch gelatinization is one critical change that takes place during frying which could be affected during low-pressure processing. This study assessed the effect of vacuum frying on starch gel...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2015.10.028

    authors: Contardo I,Parada J,Leiva A,Bouchon P

    更新日期:2016-04-15 00:00:00

  • A case of milk traceability in small-scale districts-Inner Mongolia of China by nutritional and geographical parameters.

    abstract::As far as we known, recent studies on the origin of agricultural products rarely focus on the source of cities or counties even small-scale districts, but traceability of small-scale districts of food is the research trend and difficulty of future researches. The most commonly used methods of origin tracing researches...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2020.126332

    authors: Xie L,Zhao S,Rogers KM,Xia Y,Zhang B,Suo R,Zhao Y

    更新日期:2020-06-30 00:00:00

  • Effects of industrial canning on the proximate composition, bioactive compounds contents and nutritional profile of two Spanish common dry beans (Phaseolus vulgaris L.).

    abstract::This study investigated the changes produced by canning in the proximate composition and in the bioactive constituents of two "ready to eat" Spanish beans. The foremost difference in the raw beans corresponded to the lectin: a higher content was found in raw Curruquilla beans (16.50 mg 100 mg(-1)) compared with raw Al...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.05.158

    authors: Pedrosa MM,Cuadrado C,Burbano C,Muzquiz M,Cabellos B,Olmedilla-Alonso B,Asensio-Vegas C

    更新日期:2015-01-01 00:00:00

  • Physicochemical properties of whole fruit plum powders obtained using different drying technologies.

    abstract::Physicochemical quality parameters of plum powders obtained by applying conventional drying methods and their combination devised to process plums were evaluated. The effect of freeze-drying (FD), vacuum drying (VD), convective drying (CD), microwave-vacuum drying (MVD) and combination of convective pre-drying and mic...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2016.03.075

    authors: Michalska A,Wojdyło A,Lech K,Łysiak GP,Figiel A

    更新日期:2016-09-15 00:00:00

  • Study on flavonoid migration from active low-density polyethylene film into aqueous food simulants.

    abstract::The migration of flavonoids from low-density polyethylene (LDPE) film (0.4%, w/w) to aqueous food simulants over 16 weeks at 0, 15, and 30 °C was investigated. The migration amount of total flavonoids was calculated based on the rutin contents determined by high-performance liquid chromatography (HPLC). Diffusion and ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.02.018

    authors: Zhang S,Zhao H

    更新日期:2014-08-15 00:00:00

  • Targeted separation of antibacterial peptide from protein hydrolysate of anchovy cooking wastewater by equilibrium dialysis.

    abstract::Anchovy (Engraulis japonicus) cooking wastewater (ACWW) is a by-product resulted from the production of boiled-dried anchovies in the seafood processing industry. In this study, the protein hydrolysate of ACWW (ACWWPH) was found to have antimicrobial activity after enzymatic hydrolysis with Protamex. For the targeted ...

    journal_title:Food chemistry

    pub_type: 杂志文章

    doi:10.1016/j.foodchem.2014.07.027

    authors: Tang W,Zhang H,Wang L,Qian H,Qi X

    更新日期:2015-02-01 00:00:00