当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats.

Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats.

Abstract：

:Although the pathogenesis of diabetic retinopathy (DR) is still insufficiently understood, new evidences indicate 'retinal inflammation' as an important player in the pathogenesis of the complication. Accordingly, common sets of upregulated inflammatory cytokines are found in serum, vitreous and aqueous samples obtained from subjects with DR, and these cytokines can have multiple interactions to impact the pathogenesis of the disease. Thus, based on previously published data, we investigated the effects of Palmitoylethanolamide (PEA), an endogenous lipid amide that belongs to the N-acyl-ethanolamines family, on DR in streptozotocin (STZ)-induced diabetic rats. PEA (10mg/kg) was administered orally daily starting 3 days after the iv administration of STZ. The rats were killed 15 and 60day later and eyes were enucleated to evaluate, through immunohistochemical analysis, the key inflammatory events involved in the breakdown of blood retinal barrier (BRB). Immunohistochemical analysis confirmed the presence of VEGF, ICAM-1, nitrotyrosine (a marker of peroxynitrite), and tight junctions in the retina of STZ-treated rats. Of interest, the extent of injury was significantly reduced after treatment with PEA. Altogether, this study provides the first evidence that PEA attenuates the degree of inflammation while preserving the blood-retinal barrier in rats with experimental DR.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Paterniti I,Di Paola R,Campolo M,Siracusa R,Cordaro M,Bruschetta G,Tremolada G,Maestroni A,Bandello F,Esposito E,Zerbini G,Cuzzocrea S

doi

10.1016/j.ejphar.2015.11.035

subject

Has Abstract

pub_date

2015-12-15 00:00:00

pages

313-23

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(15)30376-9

journal_volume

769

pub_type

杂志文章

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