Abstract:
OBJECTIVE:Prevalence of ankle osteoarthritis (OA) is lower than that of knee OA, however, the molecular mechanisms underlying the difference remain unrevealed. In the present study, we developed mouse ankle OA models for use as tools to investigate pathophysiology of ankle OA and molecular characteristics of ankle cartilage. DESIGN:We anatomically and histologically examined ankle and knee joints of C57BL/6 mice, and compared them with human samples. We examined joints of 8-week-old and 25-month-old mice. For experimental models, we developed three different ankle OA models: a medial model, a lateral model, and a bilateral model, by resection of respective structures. OA severity was evaluated 8 weeks after the surgery by safranin O staining, and cartilage degradation in the medial model was sequentially examined. RESULTS:Anatomical and histological features of human and mouse ankle joints were comparable. Additionally, the mouse ankle joint was more resistant to cartilage degeneration with aging than the mouse knee joint. In the medial model, the tibiotalar joint was markedly affected while the subtalar joint was less degenerated. In the lateral model, the subtalar joint was mainly affected while the tibiotalar joint was less altered. In the bilateral model, both joints were markedly degenerated. In the time course of the medial model, TdT-mediated dUTP nick end labeling (TUNEL) staining and Adamts5 expression were enhanced at early and middle stages, while Mmp13 expression was gradually increased during the OA development. CONCLUSION:Since human and mouse ankles are comparable, the present models will contribute to ankle OA pathophysiology and general cartilage research in future.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Chang SH,Yasui T,Taketomi S,Matsumoto T,Kim-Kaneyama JR,Omiya T,Hosaka Y,Inui H,Omata Y,Yamagami R,Mori D,Yano F,Chung U,Tanaka S,Saito Tdoi
10.1016/j.joca.2015.11.008subject
Has Abstractpub_date
2016-04-01 00:00:00pages
688-97issue
4eissn
1063-4584issn
1522-9653pii
S1063-4584(15)01389-8journal_volume
24pub_type
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2016.08.003
更新日期:2017-01-01 00:00:00
abstract::Human articular cartilage cells were cultured in 1.5% agarose in Dulbecco's modified Eagle's medium (DMEM) with 10% fetal calf serum or in serum-free DMEM with 0.15% bovine serum albumin. 35S-aggrecan synthesis in serum-free DMEM was between 20% and 30% of the value observed in DMEM supplemented with 10% fetal calf se...
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journal_title:Osteoarthritis and cartilage
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更新日期:2013-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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更新日期:2019-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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更新日期:2012-02-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2015.05.013
更新日期:2015-10-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 临床试验,杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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journal_title:Osteoarthritis and cartilage
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更新日期:1997-05-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1053/joca.2001.0438
更新日期:2001-01-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2013.08.004
更新日期:2013-11-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2004.05.001
更新日期:2004-08-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2004.08.004
更新日期:2004-12-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2013.09.004
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2010.03.016
更新日期:2010-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2008.08.003
更新日期:2009-04-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2006.06.017
更新日期:2007-01-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1053/joca.2002.0870
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2015.08.017
更新日期:2016-02-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,评审
doi:10.1016/j.joca.2010.03.005
更新日期:2010-06-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/s1063-4584(96)80015-x
更新日期:1996-09-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2011.07.013
更新日期:2011-10-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2004.07.004
更新日期:2004-11-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,评审
doi:10.1016/j.joca.2015.08.018
更新日期:2016-01-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,评审
doi:10.1016/j.joca.2006.02.026
更新日期:2006-01-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2004.10.023
更新日期:2005-04-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2018.08.003
更新日期:2018-12-01 00:00:00