Effectiveness of autologous chondrocyte implantation in cartilage repair of the knee: a systematic review of controlled trials.

Abstract:

OBJECTIVE:The relative differences in effectiveness of subchondral stimulation, osteochondral grafts, and autologous chondrocyte implantation (ACI) are still unclear. It is the objective of this study to systematically review the literature on ACI compared to other treatments by clinical outcome and the quality of the repair tissue, including an assessment of the validity of these findings. METHOD:The online databases PubMed, EMBASE, Cochrane Controlled Trial Register, CENTRAL, CINAHL, and BioMed were searched. Controlled trials comparing ACI with other methods of cartilage repair or placebo were included. Data on clinical outcome and the quality of the repair tissue was abstracted in duplicate. Study validity was assessed by individual components (randomization, blinded outcome assessment, sample size, attrition, percentage biopsies). RESULTS:Nine studies were included. The internal validity of most of these studies was poor. Studies comparing ACI with subchondral stimulation have a higher quality and show no differences in clinical outcomes, but suggest better results in tissue quality. The high quality evidence comparing ACI with osteochondral grafts shows better clinical outcomes and higher tissue quality after ACI. CONCLUSION:Among the included studies there is much inconsistency in methodological quality and findings. Regardless of these problems, the absolute differences between groups are fairly small, thus raising questions about their clinical importance. Future studies will be needed to answer the question of benefits of ACI compared to other treatments, and could profit from addressing and avoiding the problems seen in this group. Finally conclusions concerning long-term effects are still difficult.

authors

Vavken P,Samartzis D

doi

10.1016/j.joca.2010.03.005

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

857-63

issue

6

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(10)00078-6

journal_volume

18

pub_type

杂志文章,评审
  • The contribution of hip geometry to the prediction of hip osteoarthritis.

    abstract:OBJECTIVE:To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors. DESIGN:The study population is part of the Rotterdam Study, a prospective population-based cohort. Baseline pelvic radiographs were used to measure hip geome...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2013.06.012

    authors: Castaño-Betancourt MC,Van Meurs JB,Bierma-Zeinstra S,Rivadeneira F,Hofman A,Weinans H,Uitterlinden AG,Waarsing JH

    更新日期:2013-10-01 00:00:00

  • Dimensionality and clinical importance of pain and disability in hand osteoarthritis: Development of the Australian/Canadian (AUSCAN) Osteoarthritis Hand Index.

    abstract:OBJECTIVE:To develop a reliable, valid, and responsive self-administered questionnaire to probe pain, stiffness and physical disability in patients with osteoarthritis (OA) of the hand. DESIGN:In order to assess the dimensionality of the symptomatology of hand OA, a self-administered questionnaire was developed to pro...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.2002.0837

    authors: Bellamy N,Campbell J,Haraoui B,Buchbinder R,Hobby K,Roth JH,MacDermid JC

    更新日期:2002-11-01 00:00:00

  • Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs.

    abstract:OBJECTIVE:The goal of this study was to characterize the proteoglycan (PG) production and processing by bone marrow stromal cells (BMSCs) within a tissue engineered construct. METHODS:Bovine BMSCs and articular chondrocytes (ACs) were isolated from an immature calf, seeded into agarose gels, and cultured up to 32 days...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2008.01.004

    authors: Connelly JT,Wilson CG,Levenston ME

    更新日期:2008-09-01 00:00:00

  • Precision and accuracy of joint space width measurements of the medial compartment of the knee using standardized MTP semi-flexed radiographs.

    abstract:OBJECTIVE:To quantify the precision and accuracy of measurements of joint space width (JSW) and joint space narrowing (JSN) from the medial tibiofemoral compartment of knee radiographs using a simple and easily adaptable protocol. METHODS:Radiographs of a caliper (a surrogate for JSW) were obtained to determine the pr...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(03)00158-4

    authors: Dupuis DE,Beynnon BD,Richard MJ,Novotny JE,Skelly JM,Cooper SM

    更新日期:2003-10-01 00:00:00

  • Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice.

    abstract:OBJECTIVE:Lipocalin-2 (LCN2) is a recently characterized adipokine that is upregulated in chondrocytes treated with pro-inflammatory mediators and in the synovial fluid of osteoarthritis (OA) patients. Here, we explored the in vivo functions of LCN2 in OA cartilage destruction in mice. METHODS:The expression levels of...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2016.07.009

    authors: Choi WS,Chun JS

    更新日期:2017-03-01 00:00:00

  • Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment.

    abstract:OBJECTIVE:Magnetic resonance imaging (MRI) is a three-dimensional imaging technique with unparalleled ability to evaluate articular cartilage. This report reviews the current status of morphological assessment of cartilage with quantitative MRI (qMRI), and its relevance for identifying disease status, and monitoring pr...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2006.02.026

    authors: Eckstein F,Cicuttini F,Raynauld JP,Waterton JC,Peterfy C

    更新日期:2006-01-01 00:00:00

  • Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1.

    abstract:OBJECTIVE:Diacetylrhein or diacerein has shown efficacy in the treatment of both major forms of osteoarthritis (OA), coxarthrosis as well as gonarthrosis, improving clinical symptoms of the disease (pain reduction and algo-functional index). Both in-vitro and animal models studies suggest that diacerein may have also d...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.1998.0199

    authors: Felisaz N,Boumediene K,Ghayor C,Herrouin JF,Bogdanowicz P,Galerra P,Pujol JP

    更新日期:1999-05-01 00:00:00

  • Electroporation-mediated gene transfer of SOX trio to enhance chondrogenesis in adipose stem cells.

    abstract:OBJECTIVE:The aim of the present study was to determine if the electroporation-mediated gene transfer of SOX trio enhances the chondrogenic potential of adipose stem cells (ASCs). DESIGN:ASCs were transfected with SOX trio genes using an electroporation technique and cultured for 3 weeks. The pellets were analyzed for...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2011.01.005

    authors: Im GI,Kim HJ

    更新日期:2011-04-01 00:00:00

  • Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement.

    abstract:OBJECTIVE:The European Society on Clinical and Economic aspects of Osteoporosis and Osteoarthritis (ESCEO) organised a working group to evaluate the need for updating the current European guideline on clinical investigation of drugs used in the treatment of osteoarthritis (OA). DESIGN:Areas of potential attention were...

    journal_title:Osteoarthritis and cartilage

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1016/j.joca.2015.07.001

    authors: Reginster JY,Reiter-Niesert S,Bruyère O,Berenbaum F,Brandi ML,Branco J,Devogelaer JP,Herrero-Beaumont G,Kanis J,Maggi S,Maheu E,Richette P,Rizzoli R,Cooper C

    更新日期:2015-12-01 00:00:00

  • Subchondral bone in osteoarthritis: association between MRI texture analysis and histomorphometry.

    abstract:OBJECTIVE:Magnetic resonance imaging (MRI) texture analysis is a method of analyzing subchondral bone alterations in osteoarthritis (OA). The objective of this study was to evaluate the association between MR texture analysis and ground-truth subchondral bone histomorphometry at the tibial plateau. DESIGN:The local re...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2016.12.011

    authors: MacKay JW,Murray PJ,Kasmai B,Johnson G,Donell ST,Toms AP

    更新日期:2017-05-01 00:00:00

  • Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To evaluate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients using meta-analysis on randomized controlled trials (RCTs). METHOD:RCTs from systematic searches were included if they explicitly stated that hip and/or knee OA patients were randomized to eit...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.joca.2007.10.003

    authors: Christensen R,Bartels EM,Astrup A,Bliddal H

    更新日期:2008-04-01 00:00:00

  • Prevalence of sarcopenic obesity in adults with end-stage knee osteoarthritis.

    abstract:OBJECTIVE:To identify the prevalence of sarcopenic obesity, a phenotype of low muscle mass and high adiposity, in adults with end-stage knee osteoarthritis (OA). Various diagnostic criteria, including assessment of muscle/fat mass, muscle strength and physical function, were used to identify patients with and without s...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2019.05.026

    authors: Godziuk K,Prado CM,Woodhouse LJ,Forhan M

    更新日期:2019-12-01 00:00:00

  • Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study.

    abstract:OBJECTIVE:Statistical shape modelling (SSM) of hip dual-energy X-ray absorptiometry (DXA) scans has identified relationships between hip shape and radiographic hip OA (rHOA). We aimed to further elucidate shape characteristics related to rHOA by focusing on subregions identified from whole-hip shape models. METHOD:SSM...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2020.04.011

    authors: Faber BG,Bredbenner TL,Baird D,Gregory J,Saunders F,Giuraniuc CV,Aspden RM,Lane NE,Orwoll E,Tobias JH,Osteoporotic Fractures in Men (MrOS) Study Research Group.

    更新日期:2020-08-01 00:00:00

  • Intra-articular injection of the selective cyclooxygenase-2 inhibitor meloxicam (Mobic) reduces experimental osteoarthritis and nociception in rats.

    abstract:OBJECTIVE:To study the effect of intra-articular injection of meloxicam (Mobic) on the development of osteoarthritis (OA) in rats and examine concomitant changes in nociceptive behavior and the expression of mitogen-activated protein kinases (MAPKs) in articular cartilage chondrocytes. METHODS:OA was induced in Wistar...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2013.09.005

    authors: Wen ZH,Tang CC,Chang YC,Huang SY,Chen CH,Wu SC,Hsieh SP,Hsieh CS,Wang KY,Lin SY,Lee HL,Lee CH,Kuo HC,Chen WF,Jean YH

    更新日期:2013-12-01 00:00:00

  • Ultrasonographic assessment of medial femoral cartilage deformation acutely following walking and running.

    abstract:OBJECTIVE:To determine the magnitude of medial femoral cartilage deformation using ultrasonography (US) following walking and running in healthy individuals. DESIGN:Twenty-five healthy participants with no history of osteoarthritis or knee injury volunteered for this study. Medial femoral cartilage thickness was asses...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2016.12.026

    authors: Harkey MS,Blackburn JT,Davis H,Sierra-Arévalo L,Nissman D,Pietrosimone B

    更新日期:2017-06-01 00:00:00

  • Expression of microRNAs during chondrogenesis of human adipose-derived stem cells.

    abstract:OBJECTIVES:MicroRNAs (miRNAs) play an important role in the regulation of chondrogenesis of mesenchymal stem cells, but their expression still remains unknown in human adipose-derived stem cells (hADSCs). In this study the miRNA expression profile during chondrogenic differentiation of hADSC and the potential mechanism...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2012.08.024

    authors: Zhang Z,Kang Y,Zhang Z,Zhang H,Duan X,Liu J,Li X,Liao W

    更新日期:2012-12-01 00:00:00

  • C-reactive protein as a biomarker of emergent osteoarthritis.

    abstract:OBJECTIVE:We evaluated C-reactive protein (C-RP), a quantitative marker of the acute phase response, as a potential biomarker of prevalent and incident osteoarthritis of the knee (OAK). METHODS:Serum C-reactive protein concentrations were characterized with ultrasensitive rate nephelometry in a population-based sample...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.2002.0800

    authors: Sowers M,Jannausch M,Stein E,Jamadar D,Hochberg M,Lachance L

    更新日期:2002-08-01 00:00:00

  • Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial.

    abstract:OBJECTIVE:To evaluate the effect of a brace intended to reduce load in patients with medial or lateral compartmental osteoarthritis (OA) and concurrent varus or valgus alignment, respectively. DESIGN:This multi-centre randomized controlled trial (performed 2001-2003) studies the additive effect of a brace intended to ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.joca.2006.02.004

    authors: Brouwer RW,van Raaij TM,Verhaar JA,Coene LN,Bierma-Zeinstra SM

    更新日期:2006-08-01 00:00:00

  • The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study.

    abstract:OBJECTIVE:To evaluate the efficacy, safety and carry-over effect of diacerein, in comparison to piroxicam, in the treatment of Thai patients with symptomatic knee osteoarthritis (OA). DESIGN:This was a double-blind, randomised, piroxicam-controlled, parallel-group study. A 7-day non-steroidal anti-inflammatory drug wa...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.joca.2007.02.021

    authors: Louthrenoo W,Nilganuwong S,Aksaranugraha S,Asavatanabodee P,Saengnipanthkul S,Thai Study Group.

    更新日期:2007-06-01 00:00:00

  • Analysis of changes in proteoglycan content in murine articular cartilage using image analysis.

    abstract::The extracellular matrix of articular cartilage consists mainly of type II collagen and large aggregating proteoglycan (aggrecan). During arthritis and other joint diseases, the proteoglycan (PG) level of cartilage matrix is diminished, leading to impairment of normal joint function. A new method is described for meas...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(05)80070-6

    authors: van der Kraan PM,de Lange J,Vitters EL,van Beuningen HM,van Osch GJ,van Lent PL,van den Berg WB

    更新日期:1994-09-01 00:00:00

  • Risk factors for osteoarthritis: genetics.

    abstract::Although the multifactorial nature of osteoarthritis (OA) is well recognized, genetic factors have been found to be strong determinants of the disease. Evidence of a genetic influence of OA comes from a number of sources, including epidemiological studies of family history and family clustering, twin studies, and expl...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2003.09.005

    authors: Spector TD,MacGregor AJ

    更新日期:2004-01-01 00:00:00

  • Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis.

    abstract:OBJECTIVE:Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was to examine the...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2012.08.004

    authors: Harding GT,Hubley-Kozey CL,Dunbar MJ,Stanish WD,Astephen Wilson JL

    更新日期:2012-11-01 00:00:00

  • Estimating contextual effect in nonpharmacological therapies for pain in knee osteoarthritis: a systematic analytic review.

    abstract:OBJECTIVE:Conduct a systematic review and use meta-analytic techniques to estimate the proportion of total treatment effect that can be attributable to contextual effects (PCE) in adults receiving nonpharmacological, nonsurgical (NPNS) treatments for knee osteoarthritis (OA). DESIGN:We reviewed the published literatur...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2020.05.007

    authors: Chen AT,Shrestha S,Collins JE,Sullivan JK,Losina E,Katz JN

    更新日期:2020-09-01 00:00:00

  • Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene.

    abstract::Objective To determine whether meniscal cells can express a TGFbeta(1)transgene delivered by a retroviral vector, and respond to the gene product by increasing matrix synthesis. Methods Monolayer cultures of human and canine meniscal cells were infected with retroviruses carrying either a human TGFbeta(1)cDNA or marke...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.1999.0300

    authors: Goto H,Shuler FD,Niyibizi C,Fu FH,Robbins PD,Evans CH

    更新日期:2000-07-01 00:00:00

  • Symptoms of the knee and hip in individuals with and without limb length inequality.

    abstract:OBJECTIVE:This cross-sectional study examined the association of limb length inequality (LLI) with chronic joint symptoms at the hip and knee in a large, community-based sample, adjusting for the presence of radiographic osteoarthritis (OA) and other confounders. METHODS:The total study group comprised 3012 participan...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2008.11.005

    authors: Golightly YM,Allen KD,Helmick CG,Renner JB,Jordan JM

    更新日期:2009-05-01 00:00:00

  • The relationship of tibial bone perfusion to pain in knee osteoarthritis.

    abstract:OBJECTIVE:To confirm altered perfusion within tibial bone marrow lesions (BMLs) and improve our understanding on the relationship between BMLs and pain in knee osteoarthritis (OA). METHODS:Participants with moderate to severe knee OA were recruited and pain was assessed using the pain subscale of the Western Ontario a...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2012.08.025

    authors: Seah S,Wheaton D,Li L,Dyke JP,Talmo C,Harvey WF,Hunter DJ

    更新日期:2012-12-01 00:00:00

  • Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury.

    abstract:OBJECTIVE:To examine the correlation between synovial fluid cartilage markers and degree of cartilage damage determined by arthroscopic evaluation in subjects with acute knee injury. DESIGN:Chondral damage was quantified using a validated arthroscopic scoring system in 20 subjects with effusive acute knee injuries of ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/s1063-4584(97)80046-5

    authors: Bello AE,Garrett WE Jr,Wang H,Lohnes J,DeLong E,Caterson B,Kraus VB

    更新日期:1997-11-01 00:00:00

  • Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS): Longitudinal MRI-based whole joint assessment of anterior cruciate ligament injury.

    abstract:OBJECTIVE:To develop a whole joint scoring system, the Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS), for magnetic resonance imaging (MRI)-based assessment of acute anterior cruciate ligament (ACL) injury and follow-up of structural sequelae, and to assess its reliability. DESIGN:Baseline and follow-up 1.5 ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.joca.2014.03.006

    authors: Roemer FW,Frobell R,Lohmander LS,Niu J,Guermazi A

    更新日期:2014-05-01 00:00:00

  • ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.

    abstract:INTRODUCTION:Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for devel...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2017.02.791

    authors: Yang CY,Chanalaris A,Troeberg L

    更新日期:2017-07-01 00:00:00

  • Influence of oxygen tension on nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes.

    abstract:OBJECTIVES:To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes. DESIGN:Enzymatically isolated bovine chondrocytes were cultured for different periods in suspension in 21 (atmospheric), 5 or 1% (low) o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2004.09.009

    authors: Mathy-Hartert M,Burton S,Deby-Dupont G,Devel P,Reginster JY,Henrotin Y

    更新日期:2005-01-01 00:00:00