Abstract:
OBJECTIVE:We investigated whether innate differences in cytokine response were associated with the absence of osteoarthritis (OA) in old age. DESIGN:In 82 participants from a cross-sectional birth cohort, radiographs of hands, hips and knees were taken at the age of 90 years. OA was defined as a Kellgren-Lawrence score of at least two. "Free from OA" was defined at patient level as absence of hip and knee OA, and presence of OA in maximally two hand joints. The innate cytokine response was determined in whole-blood samples upon stimulation with lipopolysaccharide. Logistic regression analyses were used to investigate associations between absence of OA in relation to tertiles of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, IL-1 receptor antagonist (RA) and IL-10. Adjustments were made for gender and body mass index. RESULTS:Sixteen percent of the participants were "free from OA". Subjects in the lowest tertile of Il-1beta production had a 11-fold increased chance to be free of OA [odds ratio (OR) 11.3, confidence intervals (CI) 95% 1.1-115.9], subjects in the lowest tertile of IL-6 production had an almost 7-fold increased chance to be free of OA (OR 6.7, 95% CI 1.1-41.2). Absence of hand OA was associated with low innate production of IL-6 and IL-1RA, absence of hip OA was associated with low innate IL-1beta production. No associations were found for TNF-alpha and IL-10. CONCLUSIONS:Low innate capacity to produce the pro-inflammatory cytokines IL-1beta and IL-6 is associated with the absence of OA in old age.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Goekoop RJ,Kloppenburg M,Kroon HM,Frölich M,Huizinga TW,Westendorp RG,Gussekloo Jdoi
10.1016/j.joca.2010.03.016subject
Has Abstractpub_date
2010-07-01 00:00:00pages
942-7issue
7eissn
1063-4584issn
1522-9653pii
S1063-4584(10)00116-0journal_volume
18pub_type
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journal_title:Osteoarthritis and cartilage
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更新日期:2008-08-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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journal_title:Osteoarthritis and cartilage
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更新日期:2005-09-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.joca.2006.03.012
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To explore the relationships between C-reactive protein (CRP), metabolic syndrome (MetS) and incidence of severe knee or hip osteoarthritis (OA) in a prospective study. METHODS:A population-based cohort (n=5171, mean age 57.5+/-5.9 years) was examined between 1991 and 1994. Data was collected on lifestyle ha...
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pub_type: 杂志文章
doi:10.1016/j.joca.2008.07.003
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2015.01.001
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magnetic resonance imaging (MRI) to detect those changes. METHODS:Human cadaver patellae were investigated with quant...
journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2007.03.019
更新日期:2007-10-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2013.08.007
更新日期:2013-11-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2020.07.004
更新日期:2020-11-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2014.04.021
更新日期:2014-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2008.06.008
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joca.2016.12.007
更新日期:2017-05-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2013.01.010
更新日期:2013-04-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2009.10.009
更新日期:2010-03-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2018.08.007
更新日期:2018-12-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2005.06.008
更新日期:2005-11-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2016.06.012
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1053/joca.2000.0396
更新日期:2001-05-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1999-09-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,随机对照试验
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更新日期:2017-09-01 00:00:00
abstract::Recent analyses of Col2a1-Cre; ROSA26R reporter mice showed that synovial fibroblasts in 7-day mice were LacZ positive, due to a history of Col2a1-Cre expression conferred by their origin in the interzone of the developing joint. We have examined LacZ staining in adult Col2a1-Cre(+/0); ROSA26R(LacZ) mice, with and wit...
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