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Anti-inflammatory activity of chondroitin sulfate.

Abstract：

:Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha), enzymes with proteolytic activity (matrix metalloproteinases), and enzymes with pro-inflammatory activity (cyclooxygenase-2 and nitric oxide synthase-2). Enhanced expression of these proteins in chondrocytes and in synovial membrane appears associated to the activation and nuclear translocation of nuclear factor-kappaB (NF-kappaB). Chondroitin sulfate (CS) prevents joint space narrowing and reduces joint swelling and effusion. To produce these effects, CS elicits an anti-inflammatory effect at the chondral and synovial levels. CS and its disaccharides reduce NF-kappaB nuclear translocation, probably by diminishing extracellular signal-regulated kinase1/2, p38mitogen-activated protein kinase and c-Jun N-terminal kinase activation. This review discusses the evidence supporting that CS pleiotropic effects in chondrocytes and synoviocytes are primarily due to a common mechanism, e.g., the inhibition of NF-kappaB nuclear translocation.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Iovu M,Dumais G,du Souich P

doi

10.1016/j.joca.2008.06.008

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

S14-8

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(08)00202-1

journal_volume

16 Suppl 3

pub_type

杂志文章

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