Abstract:
OBJECTIVE:To analyze knee trabecular bone structure and spatial cartilage T(1ρ) and T(2) relaxation times using 3-T magnetic resonance imaging (MRI) in subjects with and without tears of posterior horn of the medial meniscus (PHMM). DESIGN:3-T MRI from 59 subjects (>18 years), were used to evaluate PHMM tears based on modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) scoring; and to calculate apparent trabecular bone-volume over total bone volume fraction (app. BV/TV), apparent trabecular number (app. Tb.N), apparent trabecular separation (app. Tb.Sp) and apparent trabecular thickness (app. Tb.Th) for overall femur/tibia and medial/lateral femur/tibia; and relaxation times for deep and superficial layers of articular cartilage. A repeated measures analysis using Generalized Estimating Equation (GEE) was performed to compare trabecular bone and cartilage relaxation time parameters between people with (n = 35) and without (n = 24) PHMM tears, while adjusting for age and knee OA presence. RESULTS:Subjects with PHMM tears had lower app. BV/TV and app. Tb.N, and greater app. Tb.Th, and app. Tb.Sp. They also had higher T(1ρ) times in the deep cartilage layer for lateral tibia and medial femur and higher T(2) relaxation times for the deep cartilage layer across all compartments. CONCLUSIONS:PHMM tears are associated with differences in underlying trabecular bone and deep layer of cartilage. Over-load of subchondral bone can lead to its sclerosis and stress shielding of trabecular bone leading to the resorptive changes observed in this study. The results underline the importance of interactions of trabecular bone and cartilage in the pathogenesis of knee OA in people with PHMM tears.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Kumar D,Schooler J,Zuo J,McCulloch CE,Nardo L,Link TM,Li X,Majumdar Sdoi
10.1016/j.joca.2012.09.014subject
Has Abstractpub_date
2013-01-01 00:00:00pages
86-93issue
1eissn
1063-4584issn
1522-9653pii
S1063-4584(12)00989-2journal_volume
21pub_type
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,多中心研究
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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journal_title:Osteoarthritis and cartilage
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更新日期:2017-03-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joca.2012.03.013
更新日期:2012-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/s1063-4584(03)00007-4
更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2012.08.004
更新日期:2012-11-01 00:00:00
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更新日期:2014-07-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1016/j.joca.2007.03.009
更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1053/joca.1999.0293
更新日期:2000-05-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
doi:10.1053/joca.2002.0873
更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 共识发展会议,杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00