Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis.


OBJECTIVE:Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was to examine the interacting role of moderate knee OA disease presence and obesity on knee joint mechanics during gait. METHODS:Gait analysis was performed on 104 asymptomatic and 140 individuals with moderate knee OA. Each subject group was divided into three body mass categories based on body mass index (BMI): healthy weight (BMI<25), overweight (25≤BMI≤30), and obese (BMI>30). Three-dimensional knee joint angles and net external knee joint moments were calculated and waveform principal component analysis (PCA) was applied to extract major patterns of variability from each. PC scores for major patterns were compared between groups using a two-factor ANOVA. RESULTS:Significant BMI main effects were found in the pattern of the knee adduction moment, the knee flexion moment, and the knee rotation moment during gait. Two interaction effects between moderate OA disease presence and BMI were also found that described different changes in the knee flexion moment and the knee flexion angle with increased BMI with and without knee OA. CONCLUSION:Our results suggest that increased BMI is associated with different changes in biomechanical patterns of the knee joint during gait depending on the presence of moderate knee OA.


Harding GT,Hubley-Kozey CL,Dunbar MJ,Stanish WD,Astephen Wilson JL




Has Abstract


2012-11-01 00:00:00














  • Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients.

    abstract:OBJECTIVE:Synovitis associated with osteoarthritis (OA) is directly responsible for several clinical symptoms and reflects OA's structural progression. This study sought to analyze the expression of proinflammatory mediations, including Interleukin (IL)-17 and IL-22, which play key roles in regulating inflammatory proc...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Deligne C,Casulli S,Pigenet A,Bougault C,Campillo-Gimenez L,Nourissat G,Berenbaum F,Elbim C,Houard X

    更新日期:2015-11-01 00:00:00

  • Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial.

    abstract:OBJECTIVES:Low-dose radiation therapy (LDRT) is widely used as treatment for osteoarthritis (OA) in some countries, while relatively unknown in others. Systematic literature review displayed a lack of high-level evidence for beneficial effects in clinical practice. The aim was to assess the efficacy of LDRT on symptoms...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验


    authors: Minten MJM,Leseman-Hoogenboom MM,Kloppenburg M,Kortekaas MC,Leer JW,Poortmans PMP,van den Hoogen FHJ,den Broeder AA,van den Ende CHM

    更新日期:2018-10-01 00:00:00

  • Regulation of inflammatory and catabolic responses to IL-1β in rat articular chondrocytes by microRNAs miR-122 and miR-451.

    abstract:OBJECTIVE:miR-122 stimulates proliferation of growth plate chondrocytes whereas miR-451 stimulates terminal differentiation and matrix turnover. Here, we examined the potential of these microRNA as regulators of articular chondrocytes using an in vitro model of osteoarthritis. METHODS:miR-122 and miR-451 presence in r...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Scott KM,Cohen DJ,Hays M,Nielson DW,Grinstaff MW,Lawson TB,Snyder BD,Boyan BD,Schwartz Z

    更新日期:2021-01-01 00:00:00

  • Validity of self-report measures of pain and disability for persons who have undergone arthroplasty for osteoarthritis of the carpometacarpal joint of the hand.

    abstract:OBJECTIVE:To establish the validity of three self-report scales used to measure function following arthroplasty for osteoarthritis (OA) of the carpometacarpal joint. METHOD:Persons with OA of the carpometacarpal joint (n=122) were assessed on one occasion 9-117 months following tendon interposition arthroplasty. They ...

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    pub_type: 杂志文章


    authors: MacDermid JC,Wessel J,Humphrey R,Ross D,Roth JH

    更新日期:2007-05-01 00:00:00

  • Meniscal subluxation: association with osteoarthritis and joint space narrowing.

    abstract:OBJECTIVE:Since complete meniscectomy leads to knee OA, we investigated the potential links among meniscal subluxation, joint space narrowing and symptomatic OA. MATERIALS AND METHODS:233 cases with symptomatic knee OA and 58 asymptomatic controls underwent radiography and MR imaging of the knee. Joint space narrowing...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Gale DR,Chaisson CE,Totterman SM,Schwartz RK,Gale ME,Felson D

    更新日期:1999-11-01 00:00:00

  • Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To evaluate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients using meta-analysis on randomized controlled trials (RCTs). METHOD:RCTs from systematic searches were included if they explicitly stated that hip and/or knee OA patients were randomized to eit...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审


    authors: Christensen R,Bartels EM,Astrup A,Bliddal H

    更新日期:2008-04-01 00:00:00

  • Persisting CAM deformity is associated with early cartilage degeneration after Slipped Capital Femoral Epiphysis: 11-year follow-up including dGEMRIC.

    abstract:OBJECTIVE:Slipped capital femoral epiphysis (SCFE) in adolescence is associated with increased risk of future osteoarthritis (OA). The purpose of this study was to study clinical and radiographic risk factors for early cartilage degeneration after SCFE. DESIGN:22 patients (44 hips) (mean age 24 years, range 18-27) tre...

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    pub_type: 杂志文章


    authors: Örtegren J,Peterson P,Svensson J,Tiderius CJ

    更新日期:2018-04-01 00:00:00

  • The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis.

    abstract:OBJECTIVE:A significant risk factor for anterior cruciate ligament (ACL) tears in young athletes is a reduced femoral Notch Width Index (NWI). The purpose of this study was to test if persons with knee osteoarthritis (OA) and ACL tears have smaller NWI independent of prior joint injury and osteophyte volume. METHODS:W...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究


    authors: Stein V,Li L,Guermazi A,Zhang Y,Kent Kwoh C,Eaton CB,Hunter DJ,OAI Investigators.

    更新日期:2010-02-01 00:00:00

  • Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human.

    abstract:OBJECTIVE:Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the oxidation of primary amines into ammonia and reactive species (hydrogen peroxide, aldehydes). It is highly expressed in mammalian tissues, especially in vascular smooth muscle cells and adipocytes, where it plays a role in cell differentiation and glu...

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    pub_type: 杂志文章


    authors: Filip A,Pinzano A,Bianchi A,Fève B,Jalkanen S,Gillet P,Mainard D,Lacolley P,Magdalou J,Mercier N

    更新日期:2016-07-01 00:00:00

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    abstract:OBJECTIVE:To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally nor...

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    pub_type: 杂志文章


    authors: Wirth W,Maschek S,Roemer FW,Sharma L,Duda GN,Eckstein F

    更新日期:2019-11-01 00:00:00

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    abstract:OBJECTIVE:In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engine...

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    pub_type: 杂志文章


    authors: Lee WD,Hurtig MB,Pilliar RM,Stanford WL,Kandel RA

    更新日期:2015-08-01 00:00:00

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    pub_type: 共识发展会议,杂志文章


    authors: Jordan JM,Sowers MF,Messier SP,Bradley J,Arangio G,Katz JN,Losina E,Rovati L,Bachtell N,Cooper C,Spector T,Zhang W,Gardiner J,Wahba M

    更新日期:2011-05-01 00:00:00

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    abstract:INTRODUCTION:Systematic reviews agree that knee osteoarthritis (OA) is related to occupational activities, but have not quantified the overall risks. METHODS:Systematic review of observational studies of knee OA and occupation. Job titles, elite sport, heavy work, kneeling, and other activities were included. Relative...

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    pub_type: 杂志文章,meta分析,评审


    authors: McWilliams DF,Leeb BF,Muthuri SG,Doherty M,Zhang W

    更新日期:2011-07-01 00:00:00

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    abstract:OBJECTIVE:Partial meniscectomy is the golden standard for treating a bucket-handle tear in the meniscus of the knee, but it inevitably leads to articular cartilage degeneration. Surgical creation of an access channel between the lesion and the vascularized synovial lining is intended to induce ingrowth of repair tissue...

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    pub_type: 杂志文章


    authors: van Tienen TG,Heijkants RG,de Groot JH,Pennings AJ,Poole AR,Veth RP,Buma P

    更新日期:2003-01-01 00:00:00

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Gelse K,Söder S,Eger W,Diemtar T,Aigner T

    更新日期:2003-02-01 00:00:00

  • Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice.

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    pub_type: 杂志文章


    authors: Zhu M,Chen M,Lichtler AC,O'Keefe RJ,Chen D

    更新日期:2008-01-01 00:00:00

  • Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects.

    abstract:OBJECTIVE:Currently, the surgical treatment of localized cartilage defects has limitations. Alternatively, localized cartilage defects may be treated with small biocompatible metal cartilage tacks. Our purpose was to investigate the applicability of defect-size femoral implants. Different bearing materials, cobalt-chro...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Custers RJ,Dhert WJ,van Rijen MH,Verbout AJ,Creemers LB,Saris DB

    更新日期:2007-08-01 00:00:00

  • The effects of hyaluronan during the development of osteoarthritis.

    abstract::Ninety-nine mature New Zealand White (NZW) rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups. The contralateral non-operated knees served as controls. The first group (SA) received intra-articular injections of 0.3 ml hyaluronan (HA: MW; 8 x 10(5)) beginning ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Yoshioka M,Shimizu C,Harwood FL,Coutts RD,Amiel D

    更新日期:1997-07-01 00:00:00

  • Exercise-driven metabolic pathways in healthy cartilage.

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Blazek AD,Nam J,Gupta R,Pradhan M,Perera P,Weisleder NL,Hewett TE,Chaudhari AM,Lee BS,Leblebicioglu B,Butterfield TA,Agarwal S

    更新日期:2016-07-01 00:00:00

  • Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study.

    abstract::The efficacy and the safety of intra-articular injections of sodium hyaluronate were studied in patients with osteoarthritis of the knee in a randomized multicenter double-blind study. Two hundred and nine patients received five injections of either 25 mg hyaluronate/2.5 ml (verum, N = 102) or 0.25 mg hyaluronate/2.5 ...

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:1993-10-01 00:00:00

  • Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles.

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Akhbari P,Jaggard MK,Boulangé CL,Vaghela U,Graça G,Bhattacharya R,Lindon JC,Williams HRT,Gupte CM

    更新日期:2019-12-01 00:00:00

  • Cartilage degeneration in the goat knee caused by treating localized cartilage defects with metal implants.

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Custers RJ,Dhert WJ,Saris DB,Verbout AJ,van Rijen MH,Mastbergen SC,Lafeber FP,Creemers LB

    更新日期:2010-03-01 00:00:00

  • Development and validation of a new population-based simulation model of osteoarthritis in New Zealand.

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    pub_type: 杂志文章


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    更新日期:2018-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Kendzerska T,Jüni P,King LK,Croxford R,Stanaitis I,Hawker GA

    更新日期:2017-11-01 00:00:00

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Casartelli NC,Maffiuletti NA,Item-Glatthorn JF,Staehli S,Bizzini M,Impellizzeri FM,Leunig M

    更新日期:2011-07-01 00:00:00

  • Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect induced osteoarthritis rat model.

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Qin J,Chow SK,Guo A,Wong WN,Leung KS,Cheung WH

    更新日期:2014-07-01 00:00:00

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: de Groot IB,Reijman M,Terwee CB,Bierma-Zeinstra SM,Favejee M,Roos EM,Verhaar JA

    更新日期:2007-01-01 00:00:00

  • Automated segmentation and analysis of normal and osteoarthritic knee menisci from magnetic resonance images--data from the Osteoarthritis Initiative.

    abstract:OBJECTIVE:To validate an automatic scheme for the segmentation and quantitative analysis of the medial meniscus (MM) and lateral meniscus (LM) in magnetic resonance (MR) images of the knee. METHOD:We analysed sagittal water-excited double-echo steady-state MR images of the knee from a subset of the Osteoarthritis Init...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Paproki A,Engstrom C,Chandra SS,Neubert A,Fripp J,Crozier S

    更新日期:2014-09-01 00:00:00

  • Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration.

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    pub_type: 杂志文章


    authors: Thote T,Lin AS,Raji Y,Moran S,Stevens HY,Hart M,Kamath RV,Guldberg RE,Willett NJ

    更新日期:2013-08-01 00:00:00

  • Effectiveness of autologous chondrocyte implantation in cartilage repair of the knee: a systematic review of controlled trials.

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Vavken P,Samartzis D

    更新日期:2010-06-01 00:00:00