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Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration.

Abstract：

OBJECTIVE:To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magnetic resonance imaging (MRI) to detect those changes. METHODS:Human cadaver patellae were investigated with quantitative MRI methods, T(2) and dGEMRIC, at 1.5T. Same measurements for isolated cartilage samples were performed at 9.4T. Bone samples, taken at sites matched with cartilage analyses, were measured with MRI and peripheral quantitative computed tomography (pQCT). Mechanical and quantitative microscopic methods were also utilized for both cartilage and bone samples. RESULTS:Significant differences were found between the samples with different stages of degeneration in mechanical properties, T(2) at 1.5T and proteoglycan (PG) content of articular cartilage. dGEMRIC at 9.4T discerned samples with advanced degeneration from the others. Bone variables measured with pQCT discerned samples with no or minimal and advanced degeneration, and mechanical properties of trabecular bone discerned samples with no or minimal degeneration from the others. Significant linear correlations were found between the bone and cartilage parameters. Characteristically, associations between variables were stronger within the samples with no or minimal degeneration compared to all samples. CONCLUSIONS:Quantitative MRI variables, especially T(2) relaxation time of articular cartilage, may be feasible surrogate markers for early and advanced osteoarthritic changes in joint tissues, including decreased elastic moduli, PG and collagen contents of cartilage and mineral density and volume fraction of trabecular bone. Further work is required to resolve the relaxation mechanisms at clinically applicable field strengths.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Lammentausta E,Kiviranta P,Töyräs J,Hyttinen MM,Kiviranta I,Nieminen MT,Jurvelin JS

doi

10.1016/j.joca.2007.03.019

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1149-57

issue

10

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(07)00123-9

journal_volume

15

pub_type

杂志文章

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