当前位置： SCI文献检索 > OSTEOARTHRITIS AND CARTILAGE期刊下所有文献 > Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile.

Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile.

Abstract：

OBJECTIVE:To examine the effect of beta-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase, on growth and remodeling of immature articular cartilage in vitro. DESIGN:Immature bovine articular cartilage explants from the superficial and middle layers were cultured for 13 days in serum-containing medium with or without BAPN. Variations in tissue size, accumulation of proteoglycan and collagen (COL), and tensile mechanical properties were assessed. RESULTS:The inclusion of serum resulted in expansive tissue growth, stimulation of proteoglycan and COL deposition, and a diminution of tensile integrity. Supplementation of medium with BAPN accentuated this phenotype in terms of a further increase in tissue size in explants from the superficial layer and further diminution of tensile integrity, without affecting the contents of proteoglycan and COL in explants from both the superficial and middle layers. CONCLUSION:COL crosslinking is a major factor in modulating the phenotype of cartilage growth and the associated balance between proteoglycan content and integrity of the COL network.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Asanbaeva A,Masuda K,Thonar EJ,Klisch SM,Sah RL

doi

10.1016/j.joca.2007.05.019

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

1-11

issue

1

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(07)00198-7

journal_volume

16

pub_type

杂志文章

相关文献

OSTEOARTHRITIS AND CARTILAGE文献大全
  • Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene.

    abstract：:Objective To determine whether meniscal cells can express a TGFbeta(1)transgene delivered by a retroviral vector, and respond to the gene product by increasing matrix synthesis. Methods Monolayer cultures of human and canine meniscal cells were infected with retroviruses carrying either a human TGFbeta(1)cDNA or marke...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.1999.0300

    authors： Goto H,Shuler FD,Niyibizi C,Fu FH,Robbins PD,Evans CH

    更新日期：2000-07-01 00:00:00

  • The association between patella alignment and knee pain and function: an MRI study in persons with symptomatic knee osteoarthritis.

    abstract：OBJECTIVE:The aim of the study was to examine the association between patellofemoral (PF) alignment (using standard magnetic resonance imaging (MRI) images of extended knees) and knee pain and function. DESIGN:Subjects were recruited to participate in a natural history study of symptomatic knee osteoarthritis, called ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.04.014

    authors： Kalichman L,Zhu Y,Zhang Y,Niu J,Gale D,Felson DT,Hunter D

    更新日期：2007-11-01 00:00:00

  • The role of the PCM in reducing oxidative stress induced by radical initiated photoencapsulation of chondrocytes in poly(ethylene glycol) hydrogels.

    abstract：OBJECTIVE:The objectives for this study were to determine whether radical initiated photopolymerizations typically employed for cell encapsulations lead to oxidative stress incurred by chondrocytes and whether the development of a pericellular matrix (PCM) decreases this oxidative stress and has longer-term benefits on...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2012.06.015

    authors： Farnsworth N,Bensard C,Bryant SJ

    更新日期：2012-11-01 00:00:00

  • Hip muscle weakness in patients with symptomatic femoroacetabular impingement.

    abstract：OBJECTIVE:Femoroacetabular impingement (FAI) is a pathomechanical process, which may cause hip pain, disability and early development of hip osteoarthritis (OA) in young and active adults. Patients with FAI experience functional disability during dynamic weight-bearing activities, which could originate from weakness of...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2011.04.001

    authors： Casartelli NC,Maffiuletti NA,Item-Glatthorn JF,Staehli S,Bizzini M,Impellizzeri FM,Leunig M

    更新日期：2011-07-01 00:00:00

  • The effects of hyaluronan during the development of osteoarthritis.

    abstract：:Ninety-nine mature New Zealand White (NZW) rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups. The contralateral non-operated knees served as controls. The first group (SA) received intra-articular injections of 0.3 ml hyaluronan (HA: MW; 8 x 10(5)) beginning ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(97)80021-0

    authors： Yoshioka M,Shimizu C,Harwood FL,Coutts RD,Amiel D

    更新日期：1997-07-01 00:00:00

  • The innate immune response as a mediator of osteoarthritis pain.

    abstract：:In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis (OA) joint pain. First, we give a brief description of the pain pathway in the context of OA. Then we consider how neuro-immune signaling pathways may promote OA pain. First, activation of neuronal Pattern Recognition Receptors...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,评审

    doi：10.1016/j.joca.2019.11.006

    authors： Miller RJ,Malfait AM,Miller RE

    更新日期：2020-05-01 00:00:00

  • Cytochrome c oxidase levels in chondrocytes during monolayer expansion and after return to three dimensional culture.

    abstract：OBJECTIVE:Here we investigate whether monolayer culture or culture at 21% oxygen influences activity of cytochrome c oxidase, the terminal enzyme in the respiratory chain whose activity is essential for oxidative metabolism and whether return to three dimensional (3-D) culture restores cytochrome c oxidase activity to ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.03.001

    authors： Boubriak OA,Brooks JT,Urban JP

    更新日期：2009-08-01 00:00:00

  • External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis.

    abstract：OBJECTIVE:Test the hypothesis that greater baseline peak external knee adduction moment (KAM), KAM impulse, and peak external knee flexion moment (KFM) during the stance phase of gait are associated with baseline-to-2-year medial tibiofemoral cartilage damage and bone marrow lesion progression, and cartilage thickness ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2015.02.005

    authors： Chang AH,Moisio KC,Chmiel JS,Eckstein F,Guermazi A,Prasad PV,Zhang Y,Almagor O,Belisle L,Hayes K,Sharma L

    更新日期：2015-07-01 00:00:00

  • ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.

    abstract：INTRODUCTION:Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for devel...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,评审

    doi：10.1016/j.joca.2017.02.791

    authors： Yang CY,Chanalaris A,Troeberg L

    更新日期：2017-07-01 00:00:00

  • Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method.

    abstract：OBJECTIVE:To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. DESIGN:Subjects with knee OA (Kellgren & Lawrence grade > or =2) and controls without OA (both n=26, seven women) were ma...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2010.01.002

    authors： Wolski M,Podsiadlo P,Stachowiak GW,Lohmander LS,Englund M

    更新日期：2010-05-01 00:00:00

  • Flow cytometric analysis of the human articular chondrocyte phenotype in vitro.

    abstract：OBJECTIVE:To develop flow cytometry for the study of human articular cartilage cell phenotype and to validate the method on chondrocytes cultured in different in-vitro systems. METHODS:Chondrocyte phenotype was modulated by culturing the cells under different in-vitro conditions: i.e. in monolayer and in suspension cu...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2000.0352

    authors： Wang L,Verbruggen G,Almqvist KF,Elewaut D,Broddelez C,Veys EM

    更新日期：2001-01-01 00:00:00

  • Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis.

    abstract：OBJECTIVES:To characterize the molecular events underlying cartilage injury in the early phase of mono-iodoacetate-induced osteoarthritis (OA) in rats. METHODS:Experimental osteoarthritis was induced by intra-articular injection of 0.03mg mono-iodoacetate (MIA) in Wistar rats. Animals were killed 2, 5, 10, 15 and 20 d...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2003.11.008

    authors： Dumond H,Presle N,Pottie P,Pacquelet S,Terlain B,Netter P,Gepstein A,Livne E,Jouzeau JY

    更新日期：2004-04-01 00:00:00

  • Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?

    abstract：OBJECTIVE:Adipose tissue-derived mesenchymal stem cells (ATMSCs) have been shown to differentiate into bone, cartilage, fat or muscle. However, it is not certain that ATMSCs are equal to bone marrow-derived mesenchymal stem cells (BMMSC) for their bone and cartilage forming potential. The purpose of this study was to a...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2005.05.005

    authors： Im GI,Shin YW,Lee KB

    更新日期：2005-10-01 00:00:00

  • Effect of hyaluronic acid (MW 500-730 kDa) on proteoglycan and nitric oxide production in human osteoarthritic chondrocyte cultures exposed to hydrostatic pressure.

    abstract：OBJECTIVE:This study investigated the in vitro effects of hyaluronic acid (HA) of molecular weight (MW) 500-730 kDa on human articular chondrocytes cultivated for 48 h in the presence of interleukin-1beta (IL-1beta) with and without hydrostatic cyclical pressure. DESIGN:The effects of 10 and 100 microg/ml HA with and ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2005.03.006

    authors： Fioravanti A,Cantarini L,Chellini F,Manca D,Paccagnini E,Marcolongo R,Collodel G

    更新日期：2005-08-01 00:00:00

  • Detection of changes in cartilage water content using MRI T2-mapping in vivo.

    abstract：OBJECTIVES:Osteoarthritis (OA) is the most prevalent chronic disease in the elderly, and it is generally diagnosed at an advanced state when treatment is difficult if not impossible. The early form of OA is characterized by an elevated water content in the cartilage tissue. The purpose of this study was to verify in vi...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2002.0847

    authors： Liess C,Lüsse S,Karger N,Heller M,Glüer CC

    更新日期：2002-12-01 00:00:00

  • Hypo-osmotic stress induces calcium-dependent actin reorganization in articular chondrocytes.

    abstract：OBJECTIVE:The aim of this study was to investigate the effects of hypo-osmotically induced calcium (Ca(2+)) transients on the organization of the actin cytoskeleton in articular chondrocytes. The secondary hypothesis tested was that actin restructuring following hypo-osmotic stress is mediated by gelsolin. METHODS:Iso...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/s1063-4584(02)00347-3

    authors： Erickson GR,Northrup DL,Guilak F

    更新日期：2003-03-01 00:00:00

  • Changes in biomechanical properties of tendons and ligaments from joint disuse.

    abstract：OBJECTIVE:The purpose of this paper is to review changes in the biomechanical properties of tendons and ligaments from joint disuse. METHOD:We have reviewed 37 experimental studies on joint disuse, which have been carried out with various models of disuse and with various animals. RESULTS:Immobilization of joints has...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.1998.0167

    authors： Yasuda K,Hayashi K

    更新日期：1999-01-01 00:00:00

  • Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement.

    abstract：OBJECTIVE:The European Society on Clinical and Economic aspects of Osteoporosis and Osteoarthritis (ESCEO) organised a working group to evaluate the need for updating the current European guideline on clinical investigation of drugs used in the treatment of osteoarthritis (OA). DESIGN:Areas of potential attention were...

    journal_title：Osteoarthritis and cartilage

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1016/j.joca.2015.07.001

    authors： Reginster JY,Reiter-Niesert S,Bruyère O,Berenbaum F,Brandi ML,Branco J,Devogelaer JP,Herrero-Beaumont G,Kanis J,Maggi S,Maheu E,Richette P,Rizzoli R,Cooper C

    更新日期：2015-12-01 00:00:00

  • C-reactive protein as a biomarker of emergent osteoarthritis.

    abstract：OBJECTIVE:We evaluated C-reactive protein (C-RP), a quantitative marker of the acute phase response, as a potential biomarker of prevalent and incident osteoarthritis of the knee (OAK). METHODS:Serum C-reactive protein concentrations were characterized with ultrasensitive rate nephelometry in a population-based sample...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2002.0800

    authors： Sowers M,Jannausch M,Stein E,Jamadar D,Hochberg M,Lachance L

    更新日期：2002-08-01 00:00:00

  • Expression of microRNAs during chondrogenesis of human adipose-derived stem cells.

    abstract：OBJECTIVES:MicroRNAs (miRNAs) play an important role in the regulation of chondrogenesis of mesenchymal stem cells, but their expression still remains unknown in human adipose-derived stem cells (hADSCs). In this study the miRNA expression profile during chondrogenic differentiation of hADSC and the potential mechanism...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2012.08.024

    authors： Zhang Z,Kang Y,Zhang Z,Zhang H,Duan X,Liu J,Li X,Liao W

    更新日期：2012-12-01 00:00:00

  • Proportion and associated factors of meeting the 2018 Physical Activity Guidelines for Americans in adults with or at risk for knee osteoarthritis.

    abstract：OBJECTIVES:Evaluate the prevalence of meeting the updated 2018 Physical Activity Guidelines for Americans (150 unbouted minutes in moderate-to-vigorous intensity physical activity [MVPA]) and determine cross-sectional factors associated with Guideline attainment in a community-based cohort of adults with or at elevated...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2020.03.007

    authors： Chang AH,Song J,Lee J,Chang RW,Semanik PA,Dunlop DD

    更新日期：2020-06-01 00:00:00

  • The associations between parity, other reproductive factors and cartilage in women aged 50-80 years.

    abstract：OBJECTIVE:Sex hormones and reproductive factors may be important for osteoarthritis (OA). The aim of this study was to describe the associations of parity, use of hormone replacement therapy (HRT) and oral contraceptives (OCs) with cartilage volume, cartilage defects and radiographic OA in a population-based sample of ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2011.07.020

    authors： Wei S,Venn A,Ding C,Martel-Pelletier J,Pelletier JP,Abram F,Cicuttini F,Jones G

    更新日期：2011-11-01 00:00:00

  • Persisting CAM deformity is associated with early cartilage degeneration after Slipped Capital Femoral Epiphysis: 11-year follow-up including dGEMRIC.

    abstract：OBJECTIVE:Slipped capital femoral epiphysis (SCFE) in adolescence is associated with increased risk of future osteoarthritis (OA). The purpose of this study was to study clinical and radiographic risk factors for early cartilage degeneration after SCFE. DESIGN:22 patients (44 hips) (mean age 24 years, range 18-27) tre...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2018.01.013

    authors： Örtegren J,Peterson P,Svensson J,Tiderius CJ

    更新日期：2018-04-01 00:00:00

  • Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model.

    abstract：OBJECTIVE:Protective effects of SKI 306X, a natural herbal product extracted from three herbs Clematis mandshurica, Trichosanthes kirilowii, and Prunella vulgaris, on articular cartilage was examined and compared with other osteoarthritis (OA) drugs using in vitro and in vivo models. METHODS:In vitro culture of rabbit...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2002.0526

    authors： Choi JH,Choi JH,Kim DY,Yoon JH,Youn HY,Yi JB,Rhee HI,Ryu KH,Jung K,Han CK,Kwak WJ,Cho YB

    更新日期：2002-06-01 00:00:00

  • Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla.

    abstract：OBJECTIVE:The aim of the study was to investigate the association of T2 relaxation times of the knee with early degenerative cartilage changes. Furthermore the impact of unloading the knee on T2 values was evaluated. METHODS:Forty-three patients with knee pain and an ICRS (International Cartilage Repair Society) carti...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2010.06.002

    authors： Apprich S,Welsch GH,Mamisch TC,Szomolanyi P,Mayerhoefer M,Pinker K,Trattnig S

    更新日期：2010-09-01 00:00:00

  • Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects.

    abstract：OBJECTIVE:Currently, the surgical treatment of localized cartilage defects has limitations. Alternatively, localized cartilage defects may be treated with small biocompatible metal cartilage tacks. Our purpose was to investigate the applicability of defect-size femoral implants. Different bearing materials, cobalt-chro...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.02.007

    authors： Custers RJ,Dhert WJ,van Rijen MH,Verbout AJ,Creemers LB,Saris DB

    更新日期：2007-08-01 00:00:00

  • Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells.

    abstract：OBJECTIVE:In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engine...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2015.04.010

    authors： Lee WD,Hurtig MB,Pilliar RM,Stanford WL,Kandel RA

    更新日期：2015-08-01 00:00:00

  • Articular cartilage calcification of the hip and knee is highly prevalent, independent of age but associated with histological osteoarthritis: evidence for a systemic disorder.

    abstract：OBJECTIVES:Based on the concept of a systemic predisposition for articular cartilage calcification (CC), the aim of this study was to determine the prevalence and amount of bilateral CC of hip and knee joints in an unselected sample cohort by high-resolution digital contact radiography (DCR) and to analyze the associat...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2016.06.020

    authors： Hawellek T,Hubert J,Hischke S,Krause M,Bertrand J,Pap T,Püschel K,Rüther W,Niemeier A

    更新日期：2016-12-01 00:00:00

  • Automated segmentation and analysis of normal and osteoarthritic knee menisci from magnetic resonance images--data from the Osteoarthritis Initiative.

    abstract：OBJECTIVE:To validate an automatic scheme for the segmentation and quantitative analysis of the medial meniscus (MM) and lateral meniscus (LM) in magnetic resonance (MR) images of the knee. METHOD:We analysed sagittal water-excited double-echo steady-state MR images of the knee from a subset of the Osteoarthritis Init...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2014.06.029

    authors： Paproki A,Engstrom C,Chandra SS,Neubert A,Fripp J,Crozier S

    更新日期：2014-09-01 00:00:00

  • Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities.

    abstract：OBJECTIVE:To determine the within- and between-patient variability in the concentrations of synovial fluid, serum and urine markers of joint tissue metabolism in a cohort of patients with knee pain and cartilage changes consistent with early-stage knee osteoarthritis. DESIGN:Samples of synovial fluid, serum, and urine...

    journal_title：Osteoarthritis and cartilage

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/joca.1998.0134

    authors： Lohmander LS,Dahlberg L,Eyre D,Lark M,Thonar EJ,Ryd L

    更新日期：1998-09-01 00:00:00