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Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

Abstract：

OBJECTIVES:To address the hypothesis that different types of established osteoarthritis (OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosodium iodoacetate (MIA) in the rat. METHODS:Rats received a single intra-articular injection of 0.1 mg or 1 mg MIA or saline (control). Pain behaviour (hind limb weight bearing asymmetry (WB) and hindpaw withdrawal threshold (PWT) to punctate stimulation) was assessed. Cartilage and synovium were examined by macroscopic visualisation of articular surfaces and histopathology. RESULTS:Both doses of MIA lowered PWTs, 1 mg MIA also resulted in WB asymmetry. Both doses were associated with cartilage macroscopic appearance, proteoglycan loss, abnormal chondrocyte morphology, increased numbers of vessels crossing the osteochondral junction, synovitis and macrophage infiltration into the synovium. PWTs were more strongly associated with chondrocyte morphology, synovitis and macrophage infiltration than with loss of cartilage surface integrity. CONCLUSIONS:Both pain behaviours were associated with OA structural severity and synovitis. Differences in pain phenotype following low vs higher dose of MIA were identified despite similar structural pathology. OA structural pathology as traditionally measured only partially explains the MIA-induced pain phenotype.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Nwosu LN,Mapp PI,Chapman V,Walsh DA

doi

10.1016/j.joca.2016.06.012

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1910-1917

issue

11

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(16)30144-3

journal_volume

24

pub_type

杂志文章

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