Effects of treadmill running and limb immobilization on knee cartilage degeneration and locomotor joint kinematics in rats following knee meniscal transection.

abstract：OBJECTIVE:To examine the association between sedentary behavior and blood pressure (BP) among Osteoarthritis Initiative (OAI) participants. DESIGN:We conducted a cross-sectional analysis of the OAI 48-month visit participants whose physical activity was measured using accelerometers. Participants were classified into ...

journal_title：Osteoarthritis and cartilage

authors： Sohn MW,Manheim LM,Chang RW,Greenland P,Hochberg MC,Nevitt MC,Semanik PA,Dunlop DD

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. MATERIALS AND METHODS:Venous blood and synovial ...

journal_title：Osteoarthritis and cartilage

authors： Verwilghen DR,Enzerink E,Martens A,Franck T,Balligand M,Henrotin Y,Detilleux J,Serteyn D

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Meniscal injuries can lead to mechanical overloading of articular cartilage and eventually to knee osteoarthritis. The objective was to evaluate the potential of contrast enhanced computed tomography (CECT) to image contrast agent (CA) diffusion in human menisci with a clinical cone beam CT scanner. DESIGN:I...

journal_title：Osteoarthritis and cartilage

authors： Honkanen JT,Danso EK,Suomalainen JS,Tiitu V,Korhonen RK,Jurvelin JS,Töyräs J

更新日期：2015-08-01 00:00:00

abstract：AIM:The goal of this study was to determine whether or not the intraarticular administration of hyaluronic acid can improve functional parameters, such as isokinetic muscle strength or total work and clinical test results in patients with osteoarthritis (OA) of the knee. METHOD:As part of a prospective, controlled stu...

journal_title：Osteoarthritis and cartilage

authors： Miltner O,Schneider U,Siebert CH,Niedhart C,Niethard FU

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Sensitive biomarkers are needed to understand synovial response to therapy in osteoarthritis (OA). Dynamic, contrast-enhanced magnetic resonance imaging (DCE MRI) provides quantitative, novel measures of synovial inflammation. This exploratory study examined DCE-assessed synovial response to intra-articular c...

journal_title：Osteoarthritis and cartilage

authors： Wenham CY,Balamoody S,Grainger AJ,Hensor EM,Draycott S,Hodgson R,Conaghan PG

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To characterize a novel secreted frizzled-related protein (SFRP) and determine its tissue distribution at the mRNA and protein level. METHODS:The FrzB-2 gene was identified by expressed sequence tag (EST) analysis of human tissue-derived libraries. Tissue distribution of FrzB-2 mRNA was determined by Norther...

journal_title：Osteoarthritis and cartilage

authors： James IE,Kumar S,Barnes MR,Gress CJ,Hand AT,Dodds RA,Connor JR,Bradley BR,Campbell DA,Grabill SE,Williams K,Blake SM,Gowen M,Lark MW

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:Determine the depth-varying confined and osmotic compression moduli of normal human articular cartilage from the femoral head, and test whether these moduli are dependent on fixed charge density. METHODS AND RESULTS:Using an automated instrument to allow epifluorescence microscopy analysis during confined c...

journal_title：Osteoarthritis and cartilage

authors： Chen SS,Falcovitz YH,Schneiderman R,Maroudas A,Sah RL

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:The effect of mechanical injury on chondrocyte viability and matrix degradation was studied. It was proposed that mechanical injury to human cartilage explants results in chondrocyte apoptosis with associated loss of glycosaminoglycans. DESIGN:Full thickness human cartilage explants, 5 mm in diameter were su...

journal_title：Osteoarthritis and cartilage

authors： D'Lima DD,Hashimoto S,Chen PC,Colwell CW Jr,Lotz MK

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. METHODS:3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of seve...

journal_title：Osteoarthritis and cartilage

authors： Gallo MC,Wyatt C,Pedoia V,Kumar D,Lee S,Nardo L,Link TM,Souza RB,Majumdar S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this paper is to review changes in the biomechanical properties of tendons and ligaments from joint disuse. METHOD:We have reviewed 37 experimental studies on joint disuse, which have been carried out with various models of disuse and with various animals. RESULTS:Immobilization of joints has...

journal_title：Osteoarthritis and cartilage

authors： Yasuda K,Hayashi K

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the psychometric properties of the French KOOS physical function (KOOS-PS) and HOOS physical function (HOOS-PS), specifically its feasibility, reliability, construct validity, and responsiveness. METHODS:Consecutive outpatients consulting for primary knee or hip osteoarthritis (OA) in a rheumatol...

journal_title：Osteoarthritis and cartilage

authors： Ornetti P,Perruccio AV,Roos EM,Lohmander LS,Davis AM,Maillefert JF

更新日期：2009-12-01 00:00:00

abstract：:Osteoarthritis (OA) is not caused by a simple consequence of aging and cartilage degradation. Based on the conventional paradigm, OA has been considered a degenerative joint disorder. However, the dominant clinical symptom has been characterized by a non-infectious chronic inflammatory condition with infiltration of i...

journal_title：Osteoarthritis and cartilage

authors： Nakamura H,Yoshino S,Kato T,Tsuruha J,Nishioka K

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To describe changes to the cancellous structure of femoral bone from patients with severe primary osteoarthritis by comparison with age and sex matched controls. METHOD:Specimens were taken from 18 male and 18 female pairs. One of each pair was a normal control, the other having severe primary osteoarthritis...

journal_title：Osteoarthritis and cartilage

authors： Fazzalari NL,Parkinson IH

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:In the current studies we have examined the effects of nitric oxide, and its redox derivatives peroxynitrite and S-nitrosothiol, S-nitrosocysteine, on nuclear factor kappaB (NF-kappaB) activation in cytokine-stimulated bovine chondrocytes. METHODS:The kinetics of NF-kappaB activation (p65 nuclear translocati...

journal_title：Osteoarthritis and cartilage

authors： Clancy RM,Gomez PF,Abramson SB

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI) texture analysis is a method of analyzing subchondral bone alterations in osteoarthritis (OA). The objective of this study was to evaluate the association between MR texture analysis and ground-truth subchondral bone histomorphometry at the tibial plateau. DESIGN:The local re...

journal_title：Osteoarthritis and cartilage

authors： MacKay JW,Murray PJ,Kasmai B,Johnson G,Donell ST,Toms AP

更新日期：2017-05-01 00:00:00

abstract：:The articular tissue generated on carbon fiber rods in rabbit knee joints after 75 days of intermittent active motion was compared with tissue generated on carbon fiber rods whose articular surfaces were covered with a free reversed periosteal graft. Both methods were effective in generating articular tissue; however,...

journal_title：Osteoarthritis and cartilage

authors： Curtin W,Reville W,Heapes M,Lyons J,Muckle D

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the thickness of cartilage at the posterior aspect of the medial and lateral condyle in Osteoarthritis (OA) knees compared to non-OA knees using computed tomography arthrography (CTA). DESIGN:535 consecutive knee CTAs (mean patient age = 48.7 ± 16.0; 286 males), were retrospectively analyzed. Kne...

journal_title：Osteoarthritis and cartilage

authors： Omoumi P,Michoux N,Roemer FW,Thienpont E,Vande Berg BC

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of chondroitin sulfate and/or glucosamine hydrochloride in alleviating symptoms and improving the dysfunction of Kashin-Beck disease (KBD) patients. METHODS:We undertook a cluster-randomized, placebo-controlled trial in 251 patients with KBD. Participants were randomly all...

journal_title：Osteoarthritis and cartilage

authors： Yue J,Yang M,Yi S,Dong B,Li W,Yang Z,Lu J,Zhang R,Yong J

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify differences in osteo...

journal_title：Osteoarthritis and cartilage

authors： Akhbari P,Jaggard MK,Boulangé CL,Vaghela U,Graça G,Bhattacharya R,Lindon JC,Williams HRT,Gupte CM

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:We aimed to (1) determine reference values for trochlear morphology and patellofemoral (PF) alignment in adults without magnetic resonance imaging (MRI)-defined PF full thickness cartilage damage or knee pain; and (2) evaluate dose-response patterns for these measures with prevalent MRI-defined PF structural ...

journal_title：Osteoarthritis and cartilage

authors： Macri EM,Felson DT,Zhang Y,Guermazi A,Roemer FW,Crossley KM,Khan KM,Stefanik JJ

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms contributing to the a...

journal_title：Osteoarthritis and cartilage

authors： Xu L,Nwosu LN,Burston JJ,Millns PJ,Sagar DR,Mapp PI,Meesawatsom P,Li L,Bennett AJ,Walsh DA,Chapman V

更新日期：2016-09-01 00:00:00

abstract：:Although the multifactorial nature of osteoarthritis (OA) is well recognized, genetic factors have been found to be strong determinants of the disease. Evidence of a genetic influence of OA comes from a number of sources, including epidemiological studies of family history and family clustering, twin studies, and expl...

journal_title：Osteoarthritis and cartilage

authors： Spector TD,MacGregor AJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the oxidation of primary amines into ammonia and reactive species (hydrogen peroxide, aldehydes). It is highly expressed in mammalian tissues, especially in vascular smooth muscle cells and adipocytes, where it plays a role in cell differentiation and glu...

journal_title：Osteoarthritis and cartilage

authors： Filip A,Pinzano A,Bianchi A,Fève B,Jalkanen S,Gillet P,Mainard D,Lacolley P,Magdalou J,Mercier N

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:To determine the within- and between-patient variability in the concentrations of synovial fluid, serum and urine markers of joint tissue metabolism in a cohort of patients with knee pain and cartilage changes consistent with early-stage knee osteoarthritis. DESIGN:Samples of synovial fluid, serum, and urine...

journal_title：Osteoarthritis and cartilage

authors： Lohmander LS,Dahlberg L,Eyre D,Lark M,Thonar EJ,Ryd L

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVES:To determine T2* relaxation in articular cartilage using ultrashort echo time (UTE) imaging and bi-component analysis, with an emphasis on the deep radial and calcified cartilage. METHODS:Ten patellar samples were imaged using two-dimensional (2D) UTE and Car-Purcell-Meiboom-Gill (CPMG) sequences. UTE image...

journal_title：Osteoarthritis and cartilage

authors： Shao H,Chang EY,Pauli C,Zanganeh S,Bae W,Chung CB,Tang G,Du J

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:The effects of mechanical deformation of intact cartilage tissue on chondrocyte biosynthesis in situ have been well documented, but the mechanotransduction pathways that regulate such phenomena have not been elucidated completely. The goal of this study was to examine the effects of tissue deformation on the ...

journal_title：Osteoarthritis and cartilage

authors： Szafranski JD,Grodzinsky AJ,Burger E,Gaschen V,Hung HH,Hunziker EB

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To elucidate variations in tissue ultrastructure and incidence of pathology between fibromodulin (FM)-null mice and wild-type (WT) animals. DESIGN:FM-null and WT siblings from different age groups were compared. Serial sections were made through paraffin-embedded whole knees and investigated histologically. ...

journal_title：Osteoarthritis and cartilage

authors： Gill MR,Oldberg A,Reinholt FP

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Until now there have been no appropriate models for metacarpophalangeal osteoarthritis (OA), even though OA in this joint is a significant medical and economic problem in horses. A good model would be useful to evaluate progression and treatment of OA, particularly in this joint. Therefore, we translated the ...

journal_title：Osteoarthritis and cartilage

authors： Mastbergen SC,Pollmeier M,Fischer L,Vianen ME,Lafeber FP

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of waiting time on health and quality of life outcomes and costs of medication in total hip replacement (THR) patients in a randomized clinical trial. METHODS:395 THR patients were recruited into the study. When placed on the waiting list, patients were randomized into a short (< or =3...

journal_title：Osteoarthritis and cartilage

authors： Tuominen U,Sintonen H,Hirvonen J,Seitsalo S,Paavolainen P,Lehto M,Hietaniemi K,Blom M

更新日期：2009-09-01 00:00:00

abstract：:Animal models of osteoarthritis (OA) are essential tools for investigating the development of the disease on a more rapid timeline than human OA. Mice are particularly useful due to the plethora of genetically modified or inbred mouse strains available. The majority of available mouse models of OA use a joint injury o...

journal_title：Osteoarthritis and cartilage

authors： Christiansen BA,Guilak F,Lockwood KA,Olson SA,Pitsillides AA,Sandell LJ,Silva MJ,van der Meulen MC,Haudenschild DR

更新日期：2015-10-01 00:00:00