当前位置： SCI文献检索 > OSTEOARTHRITIS AND CARTILAGE期刊下所有文献 > T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis.

T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis.

Abstract：

OBJECTIVE:To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. METHODS:3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of severe OA at baseline [Kellgren-Lawrence (KL) score of 0-3]. 2D fast spin-echo sequences were used for semi-quantitative morphological scoring of cartilage lesions and a combined T1ρ/T2 sequence was used to quantitatively assess cartilage composition. Progression of hip OA was defined based on incident or progression of morphological semi-quantitative grade at 18 months. Baseline T1ρ and T2 relaxation times were compared between progressors and non-progressors using one-way analysis of variance and Mann-Whitney U tests and used to predict progression with binary logistic regression after adjusting for age, gender, body mass index, and KL score. Additionally, a novel voxel-based relaxometry technique was used to compare the spatial distribution of baseline T1ρ and T2 between progressors and non-progressors. RESULTS:Significantly higher baseline T1ρ and T2 values were observed in hip OA progressors compared to non-progressors, particularly in the posterosuperior and anterior aspects of the femoral cartilage. Logistic regression showed that higher baseline T1ρ or T2 values in the femoral cartilage were significantly associated with progression of femoral cartilage lesions at 18 months. CONCLUSION:T1ρ and T2 relaxation parameters are associated with morphological cartilage degeneration at 18 months and may serve as potential imaging biomarkers for progression of cartilage lesions in hip OA.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Gallo MC,Wyatt C,Pedoia V,Kumar D,Lee S,Nardo L,Link TM,Souza RB,Majumdar S

doi

10.1016/j.joca.2016.03.005

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1399-407

issue

8

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(16)01062-1

journal_volume

24

pub_type

杂志文章

相关文献

OSTEOARTHRITIS AND CARTILAGE文献大全
  • Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilage.

    abstract：OBJECTIVE:Insulin-like growth factor-I (IGF-I) is critically involved in the control of cartilage matrix metabolism. It is well known that IGF-binding protein-3 (IGFBP-3) is increased during osteoarthritis (OA), but its function(s) is not known. In other cells, IGFBP-3 can regulate IGF-I action in the extracellular env...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.06.008

    authors： Hunziker EB,Kapfinger E,Martin J,Buckwalter J,Morales TI

    更新日期：2008-02-01 00:00:00

  • Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes.

    abstract：OBJECTIVE:Differentiated articular chondrocytes express a functional bisoform of the leptin receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We hypothesized that leptin-LRb signaling in articular chondrocytes functions to modulate canonical Wnt signaling events by altering the expressi...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2010.09.006

    authors： Ohba S,Lanigan TM,Roessler BJ

    更新日期：2010-12-01 00:00:00

  • Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo.

    abstract：OBJECTIVE:We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare the reliability of this approach with conventional arthroscopic scoring ex vivo. DESIGN:Areas of in...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2016.12.007

    authors： Sarin JK,Brommer H,Argüelles D,Puhakka PH,Inkinen SI,Afara IO,Saarakkala S,Töyräs J

    更新日期：2017-05-01 00:00:00

  • Mechanical properties of articular cartilage covered by the meniscus.

    abstract：OBJECTIVE:To investigate the mechanical properties and morphological characteristics of articular cartilage on the tibial plateau of human knees, including the region covered by the meniscus. DESIGN:Using a 1-mm diameter flat-ended cylindrical probe to apply a constant load (0.6 MPa) at specific sites on the tibial pl...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2006.01.015

    authors： Thambyah A,Nather A,Goh J

    更新日期：2006-06-01 00:00:00

  • Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters.

    abstract：OBJECTIVE:When chondrocytes prepared from cartilage are expanded in monolayer culture, fibroblast-like cells gradually prevail. Although these prevailing fibroblast-like cells are believed to emerge because of the dedifferentiation of chondrocytes, the definite origin of the prevailing fibroblast-like cells has not bee...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2013.09.004

    authors： Minegishi Y,Hosokawa K,Tsumaki N

    更新日期：2013-12-01 00:00:00

  • Standardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture.

    abstract：:Human articular cartilage cells were cultured in 1.5% agarose in Dulbecco's modified Eagle's medium (DMEM) with 10% fetal calf serum or in serum-free DMEM with 0.15% bovine serum albumin. 35S-aggrecan synthesis in serum-free DMEM was between 20% and 30% of the value observed in DMEM supplemented with 10% fetal calf se...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(05)80016-0

    authors： Verbruggen G,Malfait AM,Dewulf M,Broddelez C,Veys EM

    更新日期：1995-12-01 00:00:00

  • A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study.

    abstract：OBJECTIVE:To date semiquantitative whole-organ scoring of knee osteoarthritis (OA) relies on 1.5 Tesla (T) Magnetic resonance imaging (MRI) systems. Less costly 1.0 T extremity systems have been introduced that offer superior patient comfort, but may have limitations concerning field-of-view and image quality. The aim ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.joca.2009.08.017

    authors： Roemer FW,Lynch JA,Niu J,Zhang Y,Crema MD,Tolstykh I,El-Khoury GY,Felson DT,Lewis CE,Nevitt MC,Guermazi A

    更新日期：2010-02-01 00:00:00

  • MRI-based screening for structural definition of eligibility in clinical DMOAD trials: Rapid OsteoArthritis MRI Eligibility Score (ROAMES).

    abstract：PURPOSE:Our aim was to introduce a simplified MRI instrument, Rapid OsteoArthritis MRI Eligibility Score (ROAMES), for defining structural eligibility of patients for inclusion in disease-modifying osteoarthritis drug trials using a tri-compartmental anatomic approach that enables stratification of knees into different...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2019.08.005

    authors： Roemer FW,Collins J,Kwoh CK,Hannon MJ,Neogi T,Felson DT,Hunter DJ,Lynch JA,Guermazi A

    更新日期：2020-01-01 00:00:00

  • WOMAC Osteoarthritis Index--additional dimensions for use in subjects with post-traumatic osteoarthritis of the knee. Western Ontario and MacMaster Universities.

    abstract：OBJECTIVE:To compare the sensitivity of WOMAC and the two added dimensions Sport and Recreation Function and Knee Related Quality of Life in subjects with radiographic knee OA to that in controls. To study the influence of age on the reported outcomes. DESIGN:Outcomes were compared between subjects having had meniscec...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.1998.0153

    authors： Roos EM,Roos HP,Lohmander LS

    更新日期：1999-03-01 00:00:00

  • Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells.

    abstract：OBJECTIVE:Although SOX9 is a key molecule for chondrogenic differentiation, little is known about the upstream signal. The present study attempted to identify transcription factors to induce SOX9 expression and examined the mechanism. METHODS:Sequences of about 1 kb of 5'-end flanking regions were compared between hum...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.02.003

    authors： Ushita M,Saito T,Ikeda T,Yano F,Higashikawa A,Ogata N,Chung U,Nakamura K,Kawaguchi H

    更新日期：2009-08-01 00:00:00

  • Cartilage loss in radiographically normal knees depends on radiographic status of the contralateral knee - data from the Osteoarthritis Initiative.

    abstract：OBJECTIVE:To test whether radiographically normal knees with contralateral radiographic knee osteoarthritis (OA), but without contralateral trauma history, display greater cartilage thickness loss than knees from subjects with bilaterally radiographically normal knees. METHODS:828 radiographically normal knees (Kellgr...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2018.10.006

    authors： Eckstein F,Maschek S,Roemer FW,Duda GN,Sharma L,Wirth W

    更新日期：2019-02-01 00:00:00

  • Presence and mechanism of knee articular cartilage degeneration after meniscal reconstruction in dogs.

    abstract：OBJECTIVE:Partial meniscectomy is the golden standard for treating a bucket-handle tear in the meniscus of the knee, but it inevitably leads to articular cartilage degeneration. Surgical creation of an access channel between the lesion and the vascularized synovial lining is intended to induce ingrowth of repair tissue...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2002.0870

    authors： van Tienen TG,Heijkants RG,de Groot JH,Pennings AJ,Poole AR,Veth RP,Buma P

    更新日期：2003-01-01 00:00:00

  • Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.

    abstract：OBJECTIVE:The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN:Six experimental groups included norm...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2003.11.007

    authors： Hulmes DJ,Marsden ME,Strachan RK,Harvey RE,McInnes N,Gardner DL

    更新日期：2004-03-01 00:00:00

  • Non-invasive mouse models of post-traumatic osteoarthritis.

    abstract：:Animal models of osteoarthritis (OA) are essential tools for investigating the development of the disease on a more rapid timeline than human OA. Mice are particularly useful due to the plethora of genetically modified or inbred mouse strains available. The majority of available mouse models of OA use a joint injury o...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,评审

    doi：10.1016/j.joca.2015.05.009

    authors： Christiansen BA,Guilak F,Lockwood KA,Olson SA,Pitsillides AA,Sandell LJ,Silva MJ,van der Meulen MC,Haudenschild DR

    更新日期：2015-10-01 00:00:00

  • Should subchondral bone turnover be targeted when treating osteoarthritis?

    abstract：OBJECTIVE:Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, including bone and cartilage, thereby presenting alternative approaches for treatment. This review summarizes emergi...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,评审

    doi：10.1016/j.joca.2008.01.014

    authors： Karsdal MA,Leeming DJ,Dam EB,Henriksen K,Alexandersen P,Pastoureau P,Altman RD,Christiansen C

    更新日期：2008-06-01 00:00:00

  • ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.

    abstract：INTRODUCTION:Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for devel...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,评审

    doi：10.1016/j.joca.2017.02.791

    authors： Yang CY,Chanalaris A,Troeberg L

    更新日期：2017-07-01 00:00:00

  • Cytochrome c oxidase levels in chondrocytes during monolayer expansion and after return to three dimensional culture.

    abstract：OBJECTIVE:Here we investigate whether monolayer culture or culture at 21% oxygen influences activity of cytochrome c oxidase, the terminal enzyme in the respiratory chain whose activity is essential for oxidative metabolism and whether return to three dimensional (3-D) culture restores cytochrome c oxidase activity to ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.03.001

    authors： Boubriak OA,Brooks JT,Urban JP

    更新日期：2009-08-01 00:00:00

  • Response of engineered cartilage to mechanical insult depends on construct maturity.

    abstract：UNLABELLED:Injury to articular cartilage leads to degenerative changes resulting in a loss of mechanical and biochemical properties. In engineered cartilage, the injury response of developing constructs is unclear. OBJECTIVE:To characterize the cellular response of tissue-engineered constructs cultured in chemically-d...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2010.09.003

    authors： Tan AR,Dong EY,Ateshian GA,Hung CT

    更新日期：2010-12-01 00:00:00

  • Expression of microRNAs during chondrogenesis of human adipose-derived stem cells.

    abstract：OBJECTIVES:MicroRNAs (miRNAs) play an important role in the regulation of chondrogenesis of mesenchymal stem cells, but their expression still remains unknown in human adipose-derived stem cells (hADSCs). In this study the miRNA expression profile during chondrogenic differentiation of hADSC and the potential mechanism...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2012.08.024

    authors： Zhang Z,Kang Y,Zhang Z,Zhang H,Duan X,Liu J,Li X,Liao W

    更新日期：2012-12-01 00:00:00

  • Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells.

    abstract：OBJECTIVES:To compare the epigenetic landscape of 3D cell models of human primary articular chondrocytes (hPACs) and human bone-marrow derived mesenchymal stem cells (hBMSCs) and their respective autologous articular cartilage. DESIGN:Using Illumina Infinium HumanMethylation450 BeadChip arrays, the DNA methylation lan...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2016.03.009

    authors： Bomer N,den Hollander W,Suchiman H,Houtman E,Slieker RC,Heijmans BT,Slagboom PE,Nelissen RG,Ramos YF,Meulenbelt I

    更新日期：2016-08-01 00:00:00

  • Validation of cartilage volume and thickness measurements in the human shoulder with quantitative magnetic resonance imaging.

    abstract：OBJECTIVE:To validate quantitative magnetic resonance imaging (qMRI) for the assessment of cartilage volume and thickness in thin and curved cartilage layers, such as the shoulder. METHODS:Eight shoulder specimens from healthy individuals (aged 31-69 years) were investigated using a 3D gradient echo sequence with sele...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(03)00077-3

    authors： Graichen H,Jakob J,von Eisenhart-Rothe R,Englmeier KH,Reiser M,Eckstein F

    更新日期：2003-07-01 00:00:00

  • Depth-dependent compressive properties of normal aged human femoral head articular cartilage: relationship to fixed charge density.

    abstract：OBJECTIVES:Determine the depth-varying confined and osmotic compression moduli of normal human articular cartilage from the femoral head, and test whether these moduli are dependent on fixed charge density. METHODS AND RESULTS:Using an automated instrument to allow epifluorescence microscopy analysis during confined c...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2001.0424

    authors： Chen SS,Falcovitz YH,Schneiderman R,Maroudas A,Sah RL

    更新日期：2001-08-01 00:00:00

  • The role of the PCM in reducing oxidative stress induced by radical initiated photoencapsulation of chondrocytes in poly(ethylene glycol) hydrogels.

    abstract：OBJECTIVE:The objectives for this study were to determine whether radical initiated photopolymerizations typically employed for cell encapsulations lead to oxidative stress incurred by chondrocytes and whether the development of a pericellular matrix (PCM) decreases this oxidative stress and has longer-term benefits on...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2012.06.015

    authors： Farnsworth N,Bensard C,Bryant SJ

    更新日期：2012-11-01 00:00:00

  • Establishment of a bipotent cell line CL-1 which differentiates into chondrocytes and adipocytes from adult mouse.

    abstract：OBJECTIVE:Establishment of a clonal bipotent chondroprogenitor cell line from adult mouse to provide a new tool for the elucidation of chondrogenesis in adult animal. DESIGN:A clonal cell line CL-1 was established from tibia of adult mouse. Differentiation of CL-1 was characterized in monolayer culture. Effects of gro...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2003.09.002

    authors： Kitamura H

    更新日期：2004-01-01 00:00:00

  • Radiographic hand osteoarthritis: patterns and associations with hand pain and function in a community-dwelling sample.

    abstract：OBJECTIVE:Patterns of radiographic osteoarthritis (ROA) of the hand are often examined by row, with the four joints of the thumb studied inconsistently. The objectives of this study were to determine relationships of ROA at different hand joints, use the findings to define radiographic sub-groups and investigate their ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.05.009

    authors： Marshall M,van der Windt D,Nicholls E,Myers H,Hay E,Dziedzic K

    更新日期：2009-11-01 00:00:00

  • Prevalence of and factors associated with glucosamine use in Canada.

    abstract：OBJECTIVE:Glucosamine is commonly used for the treatment of osteoarthritis, and its use is increasing in the general population. The Canadian Multicentre Osteoporosis Study (CaMos) provided an opportunity to examine the prevalence of glucosamine use across age and gender groups, and to assess the factors associated wit...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.joca.2006.06.003

    authors： Hopman WM,Towheed TE,Gao Y,Berger C,Joseph L,Vik SA,Hanley DA,Carran J,Anastassiades T

    更新日期：2006-12-01 00:00:00

  • Clinical, biochemical and imaging methods of assessing osteoarthritis and clinical trials with agents claiming 'chondromodulating' activity.

    abstract：:This paper reviews, in a first part, methods used for the clinical assessment of osteoarthritis (OA) with special reference, in a second part, to trials of drugs claimed to be chondromodulating agents. The agents examined include glycosaminoglycan-peptide complex (GP-C, Rumalon) and glycosaminoglycan-polysulfate (GAGP...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,评审

    doi：10.1016/s1063-4584(05)80002-0

    authors： Theiler R,Ghosh P,Brooks P

    更新日期：1994-03-01 00:00:00

  • Sliding enhances fluid and solute transport into buried articular cartilage contacts.

    abstract：OBJECTIVE:Solutes and interstitial water are naturally transported from cartilage by load-induced interstitial fluid pressures. Fluid and solute recovery during joint articulation have been primarily attributed to passive diffusion and mechanical 'pumping' from dynamic loading. This paper tests if the sliding action of...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2017.08.014

    authors： Graham BT,Moore AC,Burris DL,Price C

    更新日期：2017-12-01 00:00:00

  • Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis.

    abstract：OBJECTIVE:To investigate the association between smoking and the risk for knee osteoarthritis (OA). DESIGN:Cohort, case-control, and cross-sectional studies were obtained from the Medline, Embase, and Web of Science databases. Estimates were calculated using a random-effects model. Subgroup analyses and meta-regressio...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.joca.2016.12.020

    authors： Kong L,Wang L,Meng F,Cao J,Shen Y

    更新日期：2017-06-01 00:00:00

  • Osteoarthritis and the incidence of fracture in the United Kingdom: a retrospective cohort study of 258,696 patients.

    abstract：OBJECTIVE:The goal of this study was to analyze the relationship between osteoarthritis and the incidence of fracture in men and women aged ≥18 years followed in general practices in the United Kingdom. METHODS:This study included patients aged ≥18 years who had received an initial diagnosis of osteoarthritis in one o...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2020.12.006

    authors： Jacob L,Kostev K

    更新日期：2020-12-21 00:00:00