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Depth-dependent compressive properties of normal aged human femoral head articular cartilage: relationship to fixed charge density.

Abstract：

OBJECTIVES:Determine the depth-varying confined and osmotic compression moduli of normal human articular cartilage from the femoral head, and test whether these moduli are dependent on fixed charge density. METHODS AND RESULTS:Using an automated instrument to allow epifluorescence microscopy analysis during confined compression testing on cartilage samples, the equilibrium confined compression modulus (H(A 0)) was found to vary markedly with depth (z=0-1500 microm) from the articular surface. H(A 0) increased from 1.16+/-0.20 MPa in the superficial (0-125 microm) layer to 7.75+/-1.45 MPa in the deepest (1250-1500 microm) layer tested, and was fit by the expression, H(A 0)(z) [MPa]=1.44 exp(0.0012.z [microm]). Also, in successive slices of cartilage extending from the articular surface to the middle-deep regions, the bulk modulus (K(0)) and fixed charge density (FCD) increased, consistent with previous findings. While H(A 0), K(0), and FCD each varied with depth from the articular surface, the dependence of H(A 0) and K(0) on depth did not appear to be completely related to variations in FCD. CONCLUSIONS:The confined compression modulus of normal aged human femoral head articular cartilage increases markedly with depth from the articular surface, a trend similar to that observed for articular cartilage from other joints in animals but with an absolute amplitude that is several-fold higher. The compressive properties were not simply related to FCD at different depths from the articular surface, suggesting that other as yet undefined factors also contribute to compressive properties.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Chen SS,Falcovitz YH,Schneiderman R,Maroudas A,Sah RL

doi

10.1053/joca.2001.0424

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

561-9

issue

6

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(01)90424-8

journal_volume

9

pub_type

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