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Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry.

Abstract：

OBJECTIVE:To elucidate variations in tissue ultrastructure and incidence of pathology between fibromodulin (FM)-null mice and wild-type (WT) animals. DESIGN:FM-null and WT siblings from different age groups were compared. Serial sections were made through paraffin-embedded whole knees and investigated histologically. Additionally, medial femoral condyle peaks from sibling pairs were investigated ultrastructurally using transmission electron microscopy. RESULTS:Histological findings demonstrated a clear and increasing disparity between tissue degeneration in WT and FM-null animal knees with progressing age. Distinct differences were apparent by 36 weeks. Around the 80 week period and onward these differences became profound. However, qualitative ultrastructural investigation did not indicate either any aberrant tissue ultrastructure or any abnormal collagen fibril forms in FM-null articular cartilage compared with WT. Biochemical and immunohistochemical investigation of FM-null articular cartilage showed a significant increase in tissue levels of lumican (LUM). Conversely, the cruciate ligaments of the knee showed both an increase in LUM content and considerable structural abnormalities including the tendency towards rupture. CONCLUSION:This report indicates for the first time that FM-null mice have a higher propensity towards degenerative changes in their knee joints than comparable WT animals. Interestingly, no underlying ultrastructural or fibril abnormalities within the articular cartilage could be identified to explain why FM-null cartilage is more prone to pathological changes than wild-type tissue. We conclude that alterations in ligaments, and possibly other tissues within the knee, are of considerable importance in the pathogenesis of the observed articular cartilage degeneration.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Gill MR,Oldberg A,Reinholt FP

doi

10.1053/joca.2002.0527

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

751-7

issue

eissn

1063-4584

issn

1522-9653

pii

S1063458402905273

journal_volume

pub_type

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Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry.