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Degeneration alters the biomechanical properties and structural composition of lateral human menisci.

Abstract：

OBJECTIVE:Because the literature relating to the influence of degeneration on the viscoelasticity and tissue composition of human lateral menisci remains contradictory or completely lacking, the aim of this study was to fill these gaps by comprehensively characterising the biomechanical properties of menisci with regard to the degree of degeneration. DESIGN:Meniscal tissue from 24 patients undergoing a total knee replacement was collected and the degeneration of each region classified according to Pauli et al. For biomechanical characterisation, compression and tensile tests were performed. Additionally, the water content was determined and infrared (IR) spectroscopy was applied to detect changes in the structural composition, particularly of the proteoglycan and collagen content. RESULTS:With an increasing degree of degeneration, a significant decrease of the equilibrium modulus was detected, while simultaneously the water content and the hydraulic permeability significantly increased. However, the tensile modulus displayed a tendency to decrease with increasing degeneration, which might be due to the significantly decreasing amount of collagen content identified by the IR measurements. CONCLUSION:The findings of the current study may contribute to the understanding of meniscus degeneration, showing that degenerative processes appear to mainly worsen viscoelastic properties of the inner circumference by disrupting the collagen integrity.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Warnecke D,Balko J,Haas J,Bieger R,Leucht F,Wolf N,Schild NB,Stein SEC,Seitz AM,Ignatius A,Reichel H,Mizaikoff B,Dürselen L

doi

10.1016/j.joca.2020.07.004

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1482-1491

issue

11

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(20)31080-3

journal_volume

28

pub_type

杂志文章

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