Abstract:
OBJECTIVE:The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods for hip osteoarthritis (OA). METHODS:In data obtained from trials and cohorts, radiographs were evaluated using the Kellgren and Lawrence (KL) grading system, the Osteoarthritis Research Society International (OARSI) joint space narrowing score, and quantitative measurement of joint space width (JSW), analysed as a categorical variable according to Croft and Lane's cutoffs (1.5, 2.5 and 3mm). Predictive validity was assessed through logistic regression to predict joint replacement in one database. Construct validity was assessed through logistic regression between pain and function and X-ray stages. Inter-observer and intra-observer reliability were assessed in 50 subjects by weighted kappa. Sensitivity to change was assessed in 50 patients over a 24-month interval, by standardized response mean (SRM). RESULTS:Radiographs were available from one trial and two cohorts (1404 X-rays). All three methods predicted joint replacement in the trial. Correlation with clinical parameters was low for the three scoring methods, except for the single community-based cohort. Interrater reliability was higher for categorical JSW (kappa, 0.71 vs 0.44 and 0.47 for KL and OARSI, respectively). Intrarater reliability was similar for the three methods (0.79 vs 0.69 and 0.81). Sensitivity to change was higher for categorical JSW than KL and OARSI (SRM, 0.77 vs 0.28 and 0.35). CONCLUSION:Categorical JSW has similar validity and higher sensitivity to change than the other categorical scoring techniques in hip OA. These results indicate categorical JSW may be the preferred method to evaluate structural severity in hip OA clinical trials.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Gossec L,Jordan JM,Lam MA,Fang F,Renner JB,Davis A,Hawker GA,Dougados M,Maillefert JF,OARSI-OMERACT task force \total articular replacement as outcome measure in OA\.doi
10.1016/j.joca.2008.06.009subject
Has Abstractpub_date
2009-02-01 00:00:00pages
182-7issue
2eissn
1063-4584issn
1522-9653pii
S1063-4584(08)00206-9journal_volume
17pub_type
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pub_type: 共识发展会议,杂志文章,评审
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更新日期:2002-08-01 00:00:00
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更新日期:1995-09-01 00:00:00
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