Increased rate of hysterectomy in women undergoing surgery for osteoarthritis of the knee.


:We performed a case-controlled study to determine whether previous gynecological surgery is associated with severe osteoarthritis (OA) of the knee, the hip or the spine, as well as mild OA of the knee. Patients who underwent surgical treatment for OA were defined as having severe OA. Patients with knee pain and radiographic grade 2 OA in a tibiofemoral joint on the Kellgren and Lawrence scale were defined as having mild knee OA. An increased rate of hysterectomy was observed in the severe knee OA group after adjustment for age and number of children, or even after adjustment for body mass index. Hysterectomy in this group was most often performed for myoma uteri. Patients with mild knee OA tended to have previous hysterectomy. From the results, we speculate that certain subsets of OA which often take a progressive course might be related to hysterectomy.


Inoue K,Ushiyama T,Kim Y,Shichikawa K,Nishioka J,Hukuda S




Has Abstract


1995-09-01 00:00:00














  • The response of elderly human articular cartilage to mechanical stimuli in vitro.

    abstract:OBJECTIVE:To investigate the biosynthetic response of elderly human femoral head articular cartilage to mechanical stimulation in vitro and its variation with site. METHOD:Full-depth cartilage biopsies of articular cartilage were removed from defined sites on 10 femoral heads from patients aged 68-95 years. Cartilage ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Plumb MS,Aspden RM

    更新日期:2005-12-01 00:00:00

  • Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry.

    abstract:OBJECTIVE:To elucidate variations in tissue ultrastructure and incidence of pathology between fibromodulin (FM)-null mice and wild-type (WT) animals. DESIGN:FM-null and WT siblings from different age groups were compared. Serial sections were made through paraffin-embedded whole knees and investigated histologically. ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Gill MR,Oldberg A,Reinholt FP

    更新日期:2002-10-01 00:00:00

  • Bisphosphonates reduce bone mineral loss at ligament entheses after joint injury.

    abstract:OBJECTIVE:To examine the effects of anterior cruciate ligament (ACL) insufficiency, and subsequent bisphosphonate (BP) antiresorptive therapy, on the bone mineral interface at the enthesis of remaining ligamentous restraints. METHODS:We measured bone mineral geometry (and subsequent adaptation) at the medial collatera...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Doschak MR,LaMothe JM,Cooper DM,Hallgrimsson B,Hanley DA,Bray RC,Zernicke RF

    更新日期:2005-09-01 00:00:00

  • Mechanical properties of articular cartilage covered by the meniscus.

    abstract:OBJECTIVE:To investigate the mechanical properties and morphological characteristics of articular cartilage on the tibial plateau of human knees, including the region covered by the meniscus. DESIGN:Using a 1-mm diameter flat-ended cylindrical probe to apply a constant load (0.6 MPa) at specific sites on the tibial pl...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Thambyah A,Nather A,Goh J

    更新日期:2006-06-01 00:00:00

  • T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis.

    abstract:OBJECTIVE:To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. METHODS:3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of seve...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Gallo MC,Wyatt C,Pedoia V,Kumar D,Lee S,Nardo L,Link TM,Souza RB,Majumdar S

    更新日期:2016-08-01 00:00:00

  • Influence of oxygen tension on nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes.

    abstract:OBJECTIVES:To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes. DESIGN:Enzymatically isolated bovine chondrocytes were cultured for different periods in suspension in 21 (atmospheric), 5 or 1% (low) o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Mathy-Hartert M,Burton S,Deby-Dupont G,Devel P,Reginster JY,Henrotin Y

    更新日期:2005-01-01 00:00:00

  • Altered cartilage mechanics and histology in knee osteoarthritis: relation to clinical assessment (ICRS Grade).

    abstract:OBJECTIVE:Substantial changes in articular cartilage composition and mechanical properties occur during the development of osteoarthritis (OA). While softening in the initial stage is reported and sometimes used as an indicator of early OA, there is a lack of data relating the macroscopic appearance of cartilage to its...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Kleemann RU,Krocker D,Cedraro A,Tuischer J,Duda GN

    更新日期:2005-11-01 00:00:00

  • Systematic review of non-surgical therapies for osteoarthritis of the hand: an update.

    abstract:OBJECTIVE:To update our earlier systematic review which evaluated all published randomized controlled trials (RCTs) evaluating pharmacological and non-pharmacological therapies in patients with hand osteoarthritis (OA). Surgical therapies were not evaluated. METHOD:RCTs published between August 2004 and February 2008 ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Mahendira D,Towheed TE

    更新日期:2009-10-01 00:00:00

  • Subsets of symptomatic hand osteoarthritis in community-dwelling older adults in the United Kingdom: prevalence, inter-relationships, risk factor profiles and clinical characteristics at baseline and 3-years.

    abstract:OBJECTIVE:To compare the population prevalence, inter-relationships, risk factor profiles and clinical characteristics of subsets of symptomatic hand osteoarthritis (OA) with a view to understanding their relative frequency and distinctiveness. METHOD:1076 community-dwelling adults with hand symptoms (60% women, mean ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Marshall M,Peat G,Nicholls E,van der Windt D,Myers H,Dziedzic K

    更新日期:2013-11-01 00:00:00

  • Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects.

    abstract:OBJECTIVE:Currently, the surgical treatment of localized cartilage defects has limitations. Alternatively, localized cartilage defects may be treated with small biocompatible metal cartilage tacks. Our purpose was to investigate the applicability of defect-size femoral implants. Different bearing materials, cobalt-chro...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Custers RJ,Dhert WJ,van Rijen MH,Verbout AJ,Creemers LB,Saris DB

    更新日期:2007-08-01 00:00:00

  • Dynamic knee loading is related to cartilage defects and tibial plateau bone area in medial knee osteoarthritis.

    abstract:OBJECTIVE:To evaluate the relationship between dynamic mechanical loading, as indicated by external knee adduction moment (KAM) measures during walking, and measures of articular cartilage morphology and subchondral bone size in people with medial knee osteoarthritis (OA). DESIGN:180 individuals with radiographic medi...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Creaby MW,Wang Y,Bennell KL,Hinman RS,Metcalf BR,Bowles KA,Cicuttini FM

    更新日期:2010-11-01 00:00:00

  • Low-energy impact of human cartilage: predictors for microcracking the network of collagen.

    abstract:OBJECTIVE:We aimed to determine the minimum mechanical impact to cause microstructural damage in the network of collagen (microcracking) within human cartilage and hypothesized that energies below 0.1 J or 1 mJ/mm3 would suffice. DESIGN:We completed 108 low-energy impact tests (0.05, 0.07, or 0.09 J; 0.75 or 1.0 m/s2)...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Kaleem B,Maier F,Drissi H,Pierce DM

    更新日期:2017-04-01 00:00:00

  • Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration.

    abstract:OBJECTIVE:To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magnetic resonance imaging (MRI) to detect those changes. METHODS:Human cadaver patellae were investigated with quant...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Lammentausta E,Kiviranta P,Töyräs J,Hyttinen MM,Kiviranta I,Nieminen MT,Jurvelin JS

    更新日期:2007-10-01 00:00:00

  • Effectiveness of autologous chondrocyte implantation in cartilage repair of the knee: a systematic review of controlled trials.

    abstract:OBJECTIVE:The relative differences in effectiveness of subchondral stimulation, osteochondral grafts, and autologous chondrocyte implantation (ACI) are still unclear. It is the objective of this study to systematically review the literature on ACI compared to other treatments by clinical outcome and the quality of the ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Vavken P,Samartzis D

    更新日期:2010-06-01 00:00:00

  • Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.

    abstract:OBJECTIVE:To investigate the in vivo role of the IRE1/XBP1 unfolded protein response (UPR) signaling pathway in cartilage. DESIGN:Xbp1(flox/flox).Col2a1-Cre mice (Xbp1(CartΔEx2)), in which XBP1 activity is ablated specifically from cartilage, were analyzed histomorphometrically by Alizarin red/Alcian blue skeletal pre...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Cameron TL,Gresshoff IL,Bell KM,Piróg KA,Sampurno L,Hartley CL,Sanford EM,Wilson R,Ermann J,Boot-Handford RP,Glimcher LH,Briggs MD,Bateman JF

    更新日期:2015-04-01 00:00:00

  • The impact of a significant weight loss on inflammation assessed on DCE-MRI and static MRI in knee osteoarthritis: a prospective cohort study.

    abstract:OBJECTIVE:To study the impact of weight loss on inflammation in individuals with overweight and knee osteoarthritis (OA) using both static- and dynamic contrast-enhanced (DCE)-MRI and assess the association of these changes to pain. DESIGN:Individuals with overweight (BMI > 27) and knee OA were examined before and aft...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Daugaard CL,Henriksen M,Riis RGC,Bandak E,Nybing JD,Hangaard S,Bliddal H,Boesen M

    更新日期:2020-06-01 00:00:00

  • The association between patella alignment and knee pain and function: an MRI study in persons with symptomatic knee osteoarthritis.

    abstract:OBJECTIVE:The aim of the study was to examine the association between patellofemoral (PF) alignment (using standard magnetic resonance imaging (MRI) images of extended knees) and knee pain and function. DESIGN:Subjects were recruited to participate in a natural history study of symptomatic knee osteoarthritis, called ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Kalichman L,Zhu Y,Zhang Y,Niu J,Gale D,Felson DT,Hunter D

    更新日期:2007-11-01 00:00:00

  • Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles.

    abstract:OBJECTIVE:The hip and knee joints differ biomechanically in terms of contact stresses, fluid lubrication and wear patterns. These differences may be reflected in the synovial fluid (SF) composition of the two joints, but the nature of these differences remains unknown. The objective was to identify differences in osteo...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Akhbari P,Jaggard MK,Boulangé CL,Vaghela U,Graça G,Bhattacharya R,Lindon JC,Williams HRT,Gupte CM

    更新日期:2019-12-01 00:00:00

  • Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case-control analysis.

    abstract:OBJECTIVES:Emerging evidence suggests that diabetes may be a risk factor for osteoarthritis (OA). However, previous results on the association between diabetes and all OA were conflicting. We aimed to comprehensively analyse the association between type II diabetes mellitus (T2DM) and osteoarthritis of the hand (HOA) s...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Frey N,Hügle T,Jick SS,Meier CR,Spoendlin J

    更新日期:2016-09-01 00:00:00

  • Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice.

    abstract:OBJECTIVE:To determine the specificity and efficiency of the tamoxifen (TM)-induced Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. METHODS:Col2a1-CreER(T2) transgenic mice were bred with Rosa26 reporter mice. Two-week-old Col2a1-CreER(T2);R26R mice were administered TM for 5 day...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Zhu M,Chen M,Lichtler AC,O'Keefe RJ,Chen D

    更新日期:2008-01-01 00:00:00

  • Osteoarthritis year 2012 in review: imaging.

    abstract:PURPOSE:This article reviews original publications related to imaging in osteoarthritis (OA) published in English from September 2011 through March 2012. In vitro data and animal studies are not covered. METHODS:To extract relevant studies, an extensive PubMed database search was performed using the query terms "osteo...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Roemer FW,Guermazi A

    更新日期:2012-12-01 00:00:00

  • Osteoarthritis of the knee after meniscal resection: long term radiographic evaluation of disease progression.

    abstract:OBJECTIVE:To determine prevalence, incidence and progression of radiographic knee osteoarthritis (OA) in a cohort of subjects with previous meniscectomy. METHODS:We assessed 221 subjects (177 men and 44 women) with weight bearing knee radiography twice (assessment A and B) with a follow-up time ranging from 4 to 10 ye...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Paradowski PT,Lohmander LS,Englund M

    更新日期:2016-05-01 00:00:00

  • Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis.

    abstract:OBJECTIVE:To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究


    authors: Chaganti RK,Kelman A,Lui L,Yao W,Javaid MK,Bauer D,Nevitt M,Lane NE,Study Of Osteoporotic Fractures Research Group Sof.

    更新日期:2008-05-01 00:00:00

  • Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To investigate the association between smoking and the risk for knee osteoarthritis (OA). DESIGN:Cohort, case-control, and cross-sectional studies were obtained from the Medline, Embase, and Web of Science databases. Estimates were calculated using a random-effects model. Subgroup analyses and meta-regressio...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审


    authors: Kong L,Wang L,Meng F,Cao J,Shen Y

    更新日期:2017-06-01 00:00:00

  • Tibial cancellous bone changes in patients with knee osteoarthritis. A short-term longitudinal study using Fractal Signature Analysis.

    abstract:OBJECTIVE:To quantify tibial cancellous bone changes over 24 months in patients with medial compartment knee osteoarthritis (OA) subdivided into those with slow or detectable joint space narrowing (JSN). METHOD:Digitised macroradiographs (4x) were obtained at baseline and 24 months from 40 patients (F:26) and subdivid...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Messent EA,Ward RJ,Tonkin CJ,Buckland-Wright C

    更新日期:2005-06-01 00:00:00

  • Modeling and predicting osteoarthritis progression: data from the osteoarthritis initiative.

    abstract:OBJECTIVE:The goal of this study was to model the longitudinal progression of knee osteoarthritis (OA) and build a prognostic tool that uses data collected in 1 year to predict disease progression over 8 years. DESIGN:To model OA progression, we used a mixed-effects mixture model and 8-year data from the Osteoarthriti...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Halilaj E,Le Y,Hicks JL,Hastie TJ,Delp SL

    更新日期:2018-12-01 00:00:00

  • Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities.

    abstract:OBJECTIVE:To determine the within- and between-patient variability in the concentrations of synovial fluid, serum and urine markers of joint tissue metabolism in a cohort of patients with knee pain and cartilage changes consistent with early-stage knee osteoarthritis. DESIGN:Samples of synovial fluid, serum, and urine...

    journal_title:Osteoarthritis and cartilage

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lohmander LS,Dahlberg L,Eyre D,Lark M,Thonar EJ,Ryd L

    更新日期:1998-09-01 00:00:00

  • Should subchondral bone turnover be targeted when treating osteoarthritis?

    abstract:OBJECTIVE:Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, including bone and cartilage, thereby presenting alternative approaches for treatment. This review summarizes emergi...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Karsdal MA,Leeming DJ,Dam EB,Henriksen K,Alexandersen P,Pastoureau P,Altman RD,Christiansen C

    更新日期:2008-06-01 00:00:00

  • Psychological health impact on 2-year changes in pain and function in persons with knee pain: data from the Osteoarthritis Initiative.

    abstract:OBJECTIVE:We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. DESIGN:We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in a...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究


    authors: Riddle DL,Kong X,Fitzgerald GK

    更新日期:2011-09-01 00:00:00

  • Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.

    abstract:OBJECTIVE:To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. MATERIALS AND METHODS:Venous blood and synovial ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Verwilghen DR,Enzerink E,Martens A,Franck T,Balligand M,Henrotin Y,Detilleux J,Serteyn D

    更新日期:2011-11-01 00:00:00