Increased rate of hysterectomy in women undergoing surgery for osteoarthritis of the knee.


:We performed a case-controlled study to determine whether previous gynecological surgery is associated with severe osteoarthritis (OA) of the knee, the hip or the spine, as well as mild OA of the knee. Patients who underwent surgical treatment for OA were defined as having severe OA. Patients with knee pain and radiographic grade 2 OA in a tibiofemoral joint on the Kellgren and Lawrence scale were defined as having mild knee OA. An increased rate of hysterectomy was observed in the severe knee OA group after adjustment for age and number of children, or even after adjustment for body mass index. Hysterectomy in this group was most often performed for myoma uteri. Patients with mild knee OA tended to have previous hysterectomy. From the results, we speculate that certain subsets of OA which often take a progressive course might be related to hysterectomy.


Inoue K,Ushiyama T,Kim Y,Shichikawa K,Nishioka J,Hukuda S




Has Abstract


1995-09-01 00:00:00














  • Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells.

    abstract:OBJECTIVE:Although SOX9 is a key molecule for chondrogenic differentiation, little is known about the upstream signal. The present study attempted to identify transcription factors to induce SOX9 expression and examined the mechanism. METHODS:Sequences of about 1 kb of 5'-end flanking regions were compared between hum...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Ushita M,Saito T,Ikeda T,Yano F,Higashikawa A,Ogata N,Chung U,Nakamura K,Kawaguchi H

    更新日期:2009-08-01 00:00:00

  • The validity of in vivo ultrasonographic grading of osteoarthritic femoral condylar cartilage: a comparison with in vitro ultrasonographic and histologic gradings.

    abstract:OBJECTIVES:To establish an ultrasonographic (US) grading for semiquantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vivo, and compare the in vivo US grading with the in vitro US and histologic gradings. DESIGN:Ninety-five patients going to receive total knee arthroplasty because ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Lee CL,Huang MH,Chai CY,Chen CH,Su JY,Tien YC

    更新日期:2008-03-01 00:00:00

  • Osteoarthritis year in review 2017: updates on imaging advancements.

    abstract:OBJECTIVE:This narrative review covers original research publications related to imaging advancements in osteoarthritis (OA) published in the English language between 1st April 2016 and 30th April 2017. METHODS:Relevant human studies (excluding pre-clinical and in vitro studies), were searched and selected from PubMed...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Hafezi-Nejad N,Demehri S,Guermazi A,Carrino JA

    更新日期:2018-03-01 00:00:00

  • Anti-inflammatory activity of chondroitin sulfate.

    abstract::Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha), enzymes with proteolytic activity (matrix metalloproteinases), and...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Iovu M,Dumais G,du Souich P

    更新日期:2008-01-01 00:00:00

  • Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice.

    abstract:OBJECTIVE:Lipocalin-2 (LCN2) is a recently characterized adipokine that is upregulated in chondrocytes treated with pro-inflammatory mediators and in the synovial fluid of osteoarthritis (OA) patients. Here, we explored the in vivo functions of LCN2 in OA cartilage destruction in mice. METHODS:The expression levels of...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Choi WS,Chun JS

    更新日期:2017-03-01 00:00:00

  • Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case-control analysis.

    abstract:OBJECTIVES:Emerging evidence suggests that diabetes may be a risk factor for osteoarthritis (OA). However, previous results on the association between diabetes and all OA were conflicting. We aimed to comprehensively analyse the association between type II diabetes mellitus (T2DM) and osteoarthritis of the hand (HOA) s...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Frey N,Hügle T,Jick SS,Meier CR,Spoendlin J

    更新日期:2016-09-01 00:00:00

  • Standing balance post total knee arthroplasty: sensitivity to change analysis from four to twelve weeks in 466 patients.

    abstract:OBJECTIVE:Little is known about how static standing balance changes post total knee arthroplasty (TKA). The primary aim of this study was to examine the sensitivity to change and redundancy of center of pressure (COP) variables post-TKA. The secondary aim was to compare the sensitivity of these measures to standard cli...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Clark RA,Seah FJ,Chong HC,Poon CL,Tan JW,Mentiplay BF,Pua YH

    更新日期:2017-01-01 00:00:00

  • Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile.

    abstract:OBJECTIVE:To examine the effect of beta-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase, on growth and remodeling of immature articular cartilage in vitro. DESIGN:Immature bovine articular cartilage explants from the superficial and middle layers were cultured for 13 days in serum-containing medium with or wi...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Asanbaeva A,Masuda K,Thonar EJ,Klisch SM,Sah RL

    更新日期:2008-01-01 00:00:00

  • Effectiveness of autologous chondrocyte implantation in cartilage repair of the knee: a systematic review of controlled trials.

    abstract:OBJECTIVE:The relative differences in effectiveness of subchondral stimulation, osteochondral grafts, and autologous chondrocyte implantation (ACI) are still unclear. It is the objective of this study to systematically review the literature on ACI compared to other treatments by clinical outcome and the quality of the ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Vavken P,Samartzis D

    更新日期:2010-06-01 00:00:00

  • Validation of cartilage volume and thickness measurements in the human shoulder with quantitative magnetic resonance imaging.

    abstract:OBJECTIVE:To validate quantitative magnetic resonance imaging (qMRI) for the assessment of cartilage volume and thickness in thin and curved cartilage layers, such as the shoulder. METHODS:Eight shoulder specimens from healthy individuals (aged 31-69 years) were investigated using a 3D gradient echo sequence with sele...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Graichen H,Jakob J,von Eisenhart-Rothe R,Englmeier KH,Reiser M,Eckstein F

    更新日期:2003-07-01 00:00:00

  • OARSI Clinical Trials Recommendations: Design and conduct of clinical trials of surgical interventions for osteoarthritis.

    abstract::To highlight methodological challenges in the design and conduct of randomized trials of surgical interventions and to propose strategies for addressing these challenges. This paper focuses on three broad areas: enrollment; intervention; and assessment including implications for analysis. For each challenge raised in ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Katz JN,Losina E,Lohmander LS

    更新日期:2015-05-01 00:00:00

  • Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK).

    abstract:OBJECTIVES:Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels,...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究


    authors: Vos PA,DeGroot J,Huisman AM,Oostveen JC,Marijnissen AC,Bijlsma JW,van El B,Zuurmond AM,Lafeber FP

    更新日期:2010-10-01 00:00:00

  • Preferences for physical activity: a conjoint analysis involving people with chronic knee pain.

    abstract:OBJECTIVE:To investigate individual preferences for physical activity (PA) attributes in adults with chronic knee pain, to identify clusters of individuals with similar preferences, and to identify whether individuals in these clusters differ by their demographic and health characteristics. DESIGN:An adaptive conjoint...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究


    authors: Pinto D,Bockenholt U,Lee J,Chang RW,Sharma L,Finn DJ,Heinemann AW,Holl JL,Hansen P

    更新日期:2019-02-01 00:00:00

  • Bisphosphonates reduce bone mineral loss at ligament entheses after joint injury.

    abstract:OBJECTIVE:To examine the effects of anterior cruciate ligament (ACL) insufficiency, and subsequent bisphosphonate (BP) antiresorptive therapy, on the bone mineral interface at the enthesis of remaining ligamentous restraints. METHODS:We measured bone mineral geometry (and subsequent adaptation) at the medial collatera...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Doschak MR,LaMothe JM,Cooper DM,Hallgrimsson B,Hanley DA,Bray RC,Zernicke RF

    更新日期:2005-09-01 00:00:00

  • Epigenetically mediated spontaneous reduction of NFAT1 expression causes imbalanced metabolic activities of articular chondrocytes in aged mice.

    abstract:OBJECTIVE:Abnormal metabolic activities of chondrocytes may cause articular cartilage (AC) degradation, but key transcription factors regulating metabolic activities in AC of aging individuals remain unknown. This study aimed to investigate the role of transcription factor NFAT1 in regulating the expression of anabolic...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Zhang M,Lu Q,Egan B,Zhong XB,Brandt K,Wang J

    更新日期:2016-07-01 00:00:00

  • Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts.

    abstract:OBJECTIVES:To investigate the secretion profiles of matrix metalloproteinases (MMP) and their inhibitors (TIMP) in synovial fluid-derived fibroblasts and to compare them with those of tissue-derived fibroblasts. METHODS:Fibroblast cultures established from synovial tissues (TSC) and fluids (FSC) of the same OA patient...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Fuchs S,Skwara A,Bloch M,Dankbar B

    更新日期:2004-05-01 00:00:00

  • Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis.

    abstract:OBJECTIVE:To evaluate the efficacy of a single intra-articular (IA) dose of FX006, an extended-release formulation of triamcinolone acetonide (TCA) in poly(lactic-co-glycolic acid) (PLGA) microspheres, on the sequelae of repeated episodes of synovitis. DESIGN:Three flares of localized synovitis in the right knee of ra...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Kumar A,Bendele AM,Blanks RC,Bodick N

    更新日期:2015-01-01 00:00:00

  • Reinforcement of articular cartilage with a tissue-interpenetrating polymer network reduces friction and modulates interstitial fluid load support.

    abstract:OBJECTIVE:Osteoarthritis (OA) is associated with increased articular cartilage hydraulic permeability and decreased maintenance of high interstitial fluid load support (IFLS) during articulation, resulting in increased friction on the cartilage solid matrix. This study assesses frictional response following in situ syn...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Cooper BG,Lawson TB,Snyder BD,Grinstaff MW

    更新日期:2017-07-01 00:00:00

  • Qualitative and quantitative assessment of cartilage degeneration using full-field optical coherence tomography ex vivo.

    abstract:OBJECTIVE:The purpose of this study was to investigate the ability of full-field optical coherence tomography (FFOCT) to qualitatively and quantitatively evaluate cartilage degeneration using the qualitative evaluation of histology sections as the reference. DESIGN:Thirty-three human knee cartilage samples of variable...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Pailhé R,Mounier A,Boisson B,Rouchy RC,Voros S,Chipon E,Boudry I,Medici M,Hughes C,Moreau-Gaudry A

    更新日期:2018-02-01 00:00:00

  • Stepwise preconditioning enhances mesenchymal stem cell-based cartilage regeneration through epigenetic modification.

    abstract:OBJECTIVE:This study is to investigate the functions and underlying mechanisms of mesenchymal stem cells (MSCs) underwent stepwise preconditioning in chondrogenic medium before expansion, then further explore their therapeutic effects in a surgically induced osteoarthritis (OA) model. METHODS:MSCs isolated from the ad...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Lin S,Lee WYW,Xu L,Wang Y,Chen Y,Ho KKW,Qin L,Jiang X,Cui L,Li G

    更新日期:2017-09-01 00:00:00

  • Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect induced osteoarthritis rat model.

    abstract:OBJECTIVES:To evaluate the effects of low-magnitude high-frequency vibration (LMHFV) on degenerated articular cartilage and subchondral bone in anterior cruciate ligament transection (ACLT) induced osteoarthritis (OA) rat model. METHODS:6 months old female Sprague-Dawley rats received ACLT on right knee and randomly d...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Qin J,Chow SK,Guo A,Wong WN,Leung KS,Cheung WH

    更新日期:2014-07-01 00:00:00

  • Subchondral bone in osteoarthritis: association between MRI texture analysis and histomorphometry.

    abstract:OBJECTIVE:Magnetic resonance imaging (MRI) texture analysis is a method of analyzing subchondral bone alterations in osteoarthritis (OA). The objective of this study was to evaluate the association between MR texture analysis and ground-truth subchondral bone histomorphometry at the tibial plateau. DESIGN:The local re...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: MacKay JW,Murray PJ,Kasmai B,Johnson G,Donell ST,Toms AP

    更新日期:2017-05-01 00:00:00

  • Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis.

    abstract:OBJECTIVE:Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was to examine the...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Harding GT,Hubley-Kozey CL,Dunbar MJ,Stanish WD,Astephen Wilson JL

    更新日期:2012-11-01 00:00:00

  • Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? - data from the Osteoarthritis Initiative (OAI).

    abstract:OBJECTIVE:To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally nor...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Wirth W,Maschek S,Roemer FW,Sharma L,Duda GN,Eckstein F

    更新日期:2019-11-01 00:00:00

  • Exercise-driven metabolic pathways in healthy cartilage.

    abstract:OBJECTIVE:Exercise is vital for maintaining cartilage integrity in healthy joints. Here we examined the exercise-driven transcriptional regulation of genes in healthy rat articular cartilage to dissect the metabolic pathways responsible for the potential benefits of exercise. METHODS:Transcriptome-wide gene expression...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Blazek AD,Nam J,Gupta R,Pradhan M,Perera P,Weisleder NL,Hewett TE,Chaudhari AM,Lee BS,Leblebicioglu B,Butterfield TA,Agarwal S

    更新日期:2016-07-01 00:00:00

  • Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-microCT.

    abstract:OBJECTIVE:The objective of this study was to evaluate the feasibility of quantifying the Equilibrium Partitioning of an Ionic Contrast agent via Microcomputed Tomography (EPIC-microCT) to nondestructively assess sulfated glycosaminoglycan (sGAG) content and distribution in rat articular cartilage ex vivo, and in doing ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Xie L,Lin AS,Guldberg RE,Levenston ME

    更新日期:2010-01-01 00:00:00

  • Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System.

    abstract:OBJECTIVE:For many years, the Histologic/Histochemical Grading System (HHGS) for osteoarthritis monitoring has been used as a histological scoring system for the quality of cartilage. There are, however, some limitations using this grading system. The goal of the investigation presented in this paper was to examine the...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Custers RJ,Creemers LB,Verbout AJ,van Rijen MH,Dhert WJ,Saris DB

    更新日期:2007-11-01 00:00:00

  • External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis.

    abstract:OBJECTIVE:Test the hypothesis that greater baseline peak external knee adduction moment (KAM), KAM impulse, and peak external knee flexion moment (KFM) during the stance phase of gait are associated with baseline-to-2-year medial tibiofemoral cartilage damage and bone marrow lesion progression, and cartilage thickness ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Chang AH,Moisio KC,Chmiel JS,Eckstein F,Guermazi A,Prasad PV,Zhang Y,Almagor O,Belisle L,Hayes K,Sharma L

    更新日期:2015-07-01 00:00:00

  • Changes in mechanics and composition of human talar cartilage anlagen during fetal development.

    abstract:OBJECTIVE:Fetal cartilage anlage provides a framework for endochondral ossification and organization into articular cartilage. We previously reported differences between mechanical properties of talar cartilage anlagen and adult articular cartilage. However, the underlying development-associated changes remain to be es...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Mahmoodian R,Leasure J,Philip P,Pleshko N,Capaldi F,Siegler S

    更新日期:2011-10-01 00:00:00

  • A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia.

    abstract:OBJECTIVE:To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density (sBMD). METHODS:A consecutive sample of 50 male and female participants from a population-based longitudinal study had sBMD assessed using dual energy X-ray absorptiometry scans. Ant...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Dore D,Ding C,Jones G

    更新日期:2008-12-01 00:00:00