Meniscal subluxation: association with osteoarthritis and joint space narrowing.


OBJECTIVE:Since complete meniscectomy leads to knee OA, we investigated the potential links among meniscal subluxation, joint space narrowing and symptomatic OA. MATERIALS AND METHODS:233 cases with symptomatic knee OA and 58 asymptomatic controls underwent radiography and MR imaging of the knee. Joint space narrowing was measured on weight-bearing PA fluoroscopy-positioned radiographs. The amount of medial or lateral meniscal subluxation was measured on coronal MR images. The prevalence and severity of meniscal subluxation was compared in cases and controls. We evaluated the correlation of the degree of meniscal subluxation with joint space narrowing, Kellgren and Lawrence grade, and two major risk factors for the development of OA, age and weight. RESULTS:Cases had more medial and lateral subluxation than controls. Mean medial meniscal subluxation was 5.1 mm in cases and 2.8 mm in controls (P=0.001). Modest degrees of meniscal subluxation were common in both cases and controls: 81% of cases and 64% of controls had >/=3 mm of subluxation; age and gender adjusted (P=0.006). Severe degrees of subluxation were almost unique to OA cases (e.g. prevalence of >/=7 mm, 35% cases vs. 7% controls, P< 0.001). Among controls, severe degrees of subluxation were present only in those with radiographic joint space narrowing (defined as >/=grade 1 narrowing on a 0-3 scale). In cases, there was a strong correlation between the degree of medial meniscal subluxation and the severity of medial joint space narrowing (r=0.56, P=0.0001). Similar results were present in the lateral compartment. Meniscal subluxation did not correlate with age or weight. CONCLUSION:Meniscal subluxation is highly associated with symptomatic knee OA. In subjects with osteoarthritis, increasing meniscal subluxation on MR correlates with the severity of joint space narrowing.


Gale DR,Chaisson CE,Totterman SM,Schwartz RK,Gale ME,Felson D





Has Abstract


1999-11-01 00:00:00














  • Differential regulation of chondrocyte metabolism by oncostatin M and interleukin-6.

    abstract:OBJECTIVE:To determine the effects of interleukin (IL)-6 and oncostatin M (OSM) added separately or in combination with IL-1beta on human osteoarthritic (OA) chondrocytes in alginate beads. DESIGN:Human chondrocytes were isolated from OA cartilage and cultured in alginate beads for 12 days, in the absence or in the pr...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Sanchez C,Deberg MA,Burton S,Devel P,Reginster JY,Henrotin YE

    更新日期:2004-10-01 00:00:00

  • Mechanical symptoms as an indication for knee arthroscopy in patients with degenerative meniscus tear: a prospective cohort study.

    abstract:OBJECTIVE:According to prevailing consensus, patients with mechanical symptoms are those considered to most likely benefit from arthroscopic surgery. The aim of this study was to determine the value of using patients' pre-operative self-reports of mechanical symptoms as a justification surgery in patients with degenera...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Sihvonen R,Englund M,Turkiewicz A,Järvinen TL

    更新日期:2016-08-01 00:00:00

  • The response of elderly human articular cartilage to mechanical stimuli in vitro.

    abstract:OBJECTIVE:To investigate the biosynthetic response of elderly human femoral head articular cartilage to mechanical stimulation in vitro and its variation with site. METHOD:Full-depth cartilage biopsies of articular cartilage were removed from defined sites on 10 femoral heads from patients aged 68-95 years. Cartilage ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Plumb MS,Aspden RM

    更新日期:2005-12-01 00:00:00

  • The volume and morphology of chondrocytes within non-degenerate and degenerate human articular cartilage.

    abstract:OBJECTIVE:Cartilage swelling is an early event in osteoarthritis (OA). However, the response of chondrocytes to increased tissue hydration is unknown. This work studied the volume and morphology of living in situ human chondrocytes as a function of cartilage degeneration. METHODS:The tibial plateaus from knee joints o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Bush PG,Hall AC

    更新日期:2003-04-01 00:00:00

  • Changes in mechanics and composition of human talar cartilage anlagen during fetal development.

    abstract:OBJECTIVE:Fetal cartilage anlage provides a framework for endochondral ossification and organization into articular cartilage. We previously reported differences between mechanical properties of talar cartilage anlagen and adult articular cartilage. However, the underlying development-associated changes remain to be es...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Mahmoodian R,Leasure J,Philip P,Pleshko N,Capaldi F,Siegler S

    更新日期:2011-10-01 00:00:00

  • Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration.

    abstract:OBJECTIVE:To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magnetic resonance imaging (MRI) to detect those changes. METHODS:Human cadaver patellae were investigated with quant...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Lammentausta E,Kiviranta P,Töyräs J,Hyttinen MM,Kiviranta I,Nieminen MT,Jurvelin JS

    更新日期:2007-10-01 00:00:00

  • Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a randomized controlled trial comparing two different physical therapy interventions.

    abstract:OBJECTIVE:To determine if behavioral graded activity (BGA) results in better long-term effectiveness (5 years after inclusion) than usual exercise therapy (UC; usual care) in patients with osteoarthritis (OA) of the hip or knee. METHOD:Long-term follow-up study of a single blind cluster randomized trial comparing BGA ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验


    authors: Pisters MF,Veenhof C,Schellevis FG,De Bakker DH,Dekker J

    更新日期:2010-08-01 00:00:00

  • "I was considering surgery because I believed that was how it was treated": a qualitative study on willingness for joint surgery after completion of a digital management program for osteoarthritis.

    abstract:OBJECTIVE:To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA). DESIGN:Nineteen patients with hi...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Cronström A,Dahlberg LE,Nero H,Hammarlund CS

    更新日期:2019-07-01 00:00:00

  • Studies of pain management in osteoarthritis: bedside to policy.

    abstract:OBJECTIVE:Osteoarthritis (OA) is a debilitating chronic condition requiring long-term treatment of pain and functional impairment. Our objective was to characterize studies addressing management of OA-related pain with respect to the breadth of interventions, trial duration and size, outcome measures, and funding sourc...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析


    authors: Losina E,Dervan EE,Daigle ME,Katz JN

    更新日期:2013-09-01 00:00:00

  • A randomized trial of patellofemoral bracing for treatment of patellofemoral osteoarthritis.

    abstract:PURPOSE:The number of effective knee osteoarthritis (OA) interventions, especially those tailored to specific compartmental involvement, are small. The objective of this study was to determine the efficacy of a realigning patellofemoral (PF) brace in improving pain and function among persons with symptomatic lateral PF...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验


    authors: Hunter DJ,Harvey W,Gross KD,Felson D,McCree P,Li L,Hirko K,Zhang B,Bennell K

    更新日期:2011-07-01 00:00:00

  • Relationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial.

    abstract:OBJECTIVE:To explore effects of weight loss and maintenance on serum cartilage biomarkers denaturation neoepitope for Collagen2 (Coll2-1) and Fibulin3 fragment (Fib3-2), as well as correlations between Coll2-1 and Fib3-2 and symptomatic improvement, in a knee osteoarthritis (KOA) population. DESIGN:192 obese KOA patie...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验


    authors: Bartels EM,Henrotin Y,Bliddal H,Centonze P,Henriksen M

    更新日期:2017-10-01 00:00:00

  • Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients.

    abstract:OBJECTIVE:Synovitis associated with osteoarthritis (OA) is directly responsible for several clinical symptoms and reflects OA's structural progression. This study sought to analyze the expression of proinflammatory mediations, including Interleukin (IL)-17 and IL-22, which play key roles in regulating inflammatory proc...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Deligne C,Casulli S,Pigenet A,Bougault C,Campillo-Gimenez L,Nourissat G,Berenbaum F,Elbim C,Houard X

    更新日期:2015-11-01 00:00:00

  • Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? - data from the Osteoarthritis Initiative (OAI).

    abstract:OBJECTIVE:To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally nor...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Wirth W,Maschek S,Roemer FW,Sharma L,Duda GN,Eckstein F

    更新日期:2019-11-01 00:00:00

  • Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.

    abstract:OBJECTIVE:To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS:Body mass index (BMI) was calculated in 45 patients (16 women),...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Ericsson YB,Tjörnstrand J,Tiderius CJ,Dahlberg LE

    更新日期:2009-05-01 00:00:00

  • Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial.

    abstract:OBJECTIVE:Recently we reported that glucosamine sulphate (GS) did not have an effect on the symptoms and progression of primary care patients with hip osteoarthritis (OA). The aim of this present study was to investigate whether there are subgroups of patients with hip OA for whom GS might be an effective therapy. MET...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验


    authors: Rozendaal RM,Uitterlinden EJ,van Osch GJ,Garling EH,Willemsen SP,Ginai AZ,Verhaar JA,Weinans H,Koes BW,Bierma-Zeinstra SM

    更新日期:2009-04-01 00:00:00

  • Evidence that human cartilage and chondrocytes do not express calcitonin receptor.

    abstract:OBJECTIVE:Calcitonin (CT) has been recently shown to exhibit direct protective effects on articular cartilage against joint degenerative disease. It has been proposed that CT might act via the CT receptor (CTR) to activate the cyclic AMP (cAMP) pathway and protect type II collagen degradation. In this study, we investi...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Lin Z,Pavlos NJ,Cake MA,Wood DJ,Xu J,Zheng MH

    更新日期:2008-04-01 00:00:00

  • Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case-control analysis.

    abstract:OBJECTIVES:Emerging evidence suggests that diabetes may be a risk factor for osteoarthritis (OA). However, previous results on the association between diabetes and all OA were conflicting. We aimed to comprehensively analyse the association between type II diabetes mellitus (T2DM) and osteoarthritis of the hand (HOA) s...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Frey N,Hügle T,Jick SS,Meier CR,Spoendlin J

    更新日期:2016-09-01 00:00:00

  • Comparison of mechanical debridement and radiofrequency energy for chondroplasty in an in vivo equine model of partial thickness cartilage injury.

    abstract:OBJECTIVE:The purpose of this study was to develop a long-term model of cartilage injury that could be used to compare the effects of radiofrequency energy (RFE) and mechanical debridement as a treatment. METHODS:Partial thickness fibrillation of patellar cartilage was created in 16 mature ponies. Three months after t...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Edwards RB 3rd,Lu Y,Uthamanthil RK,Bogdanske JJ,Muir P,Athanasiou KA,Markel MD

    更新日期:2007-02-01 00:00:00

  • 2D and 3D MOCART scoring systems assessed by 9.4 T high-field MRI correlate with elementary and complex histological scoring systems in a translational model of osteochondral repair.

    abstract:OBJECTIVE:To compare the 2D and 3D MOCART system obtained with 9.4 T high-field magnetic resonance imaging (MRI) for the ex vivo analysis of osteochondral repair in a translational model and to correlate the data with semiquantitative histological analysis. METHODS:Osteochondral samples representing all levels of repa...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Goebel L,Zurakowski D,Müller A,Pape D,Cucchiarini M,Madry H

    更新日期:2014-10-01 00:00:00

  • Cartilage degeneration in different human joints.

    abstract::Variations among joints in the initiation and progression of degeneration may be explained, in part, by metabolic, biochemical and biomechanical differences. Compared to the cartilage in the knee joint, ankle cartilage has a higher content of proteoglycans and water, as well as an increased rate of proteoglycan turnov...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Kuettner KE,Cole AA

    更新日期:2005-02-01 00:00:00

  • Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.

    abstract:OBJECTIVE:To investigate the role of Vhl in maintaining the integrity of articular cartilage and in the development of experimental osteoarthritis (OA). METHOD:Histology of articular cartilage and subchondral bone in both Vhl cKO and WT mice were analyzed by histopathology and micro-CT. Articular cartilage destruction...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Weng T,Xie Y,Yi L,Huang J,Luo F,Du X,Chen L,Liu C,Chen D,Chen L

    更新日期:2014-08-01 00:00:00

  • Regulation of inflammatory and catabolic responses to IL-1β in rat articular chondrocytes by microRNAs miR-122 and miR-451.

    abstract:OBJECTIVE:miR-122 stimulates proliferation of growth plate chondrocytes whereas miR-451 stimulates terminal differentiation and matrix turnover. Here, we examined the potential of these microRNA as regulators of articular chondrocytes using an in vitro model of osteoarthritis. METHODS:miR-122 and miR-451 presence in r...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Scott KM,Cohen DJ,Hays M,Nielson DW,Grinstaff MW,Lawson TB,Snyder BD,Boyan BD,Schwartz Z

    更新日期:2021-01-01 00:00:00

  • A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with knee osteoarthritis (Part 1 of 2): clinical results.

    abstract:OBJECTIVE:First, to assess the clinical effectiveness of hylan G-F 20 in an appropriate care treatment regimen (as defined by the American College of Rheumatology (ACR) 1995 guidelines) as measured by validated disease-specific outcomes and health-related quality of life endpoints for patients with osteoarthritis (OA) ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Raynauld JP,Torrance GW,Band PA,Goldsmith CH,Tugwell P,Walker V,Schultz M,Bellamy N,Canadian Knee OA Study Group.

    更新日期:2002-07-01 00:00:00

  • The effects of radial shock waves on gene transfer in rabbit chondrocytes in vitro.

    abstract:OBJECTIVE:The purpose of this study was to develop a new technique of gene transfer utilizing radial shock waves. The effects of radial shock waves on gene transfer in rabbit chondrocytes were examined by varying the parameters of exposure conditions in vitro. METHODS:Chondrocytes were obtained from New Zealand white ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Murata R,Nakagawa K,Ohtori S,Ochiai N,Arai M,Saisu T,Sasho T,Takahashi K,Moriya H

    更新日期:2007-11-01 00:00:00

  • Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice.

    abstract::Recent analyses of Col2a1-Cre; ROSA26R reporter mice showed that synovial fibroblasts in 7-day mice were LacZ positive, due to a history of Col2a1-Cre expression conferred by their origin in the interzone of the developing joint. We have examined LacZ staining in adult Col2a1-Cre(+/0); ROSA26R(LacZ) mice, with and wit...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Fosang AJ,Golub SB,East CJ,Rogerson FM

    更新日期:2013-02-01 00:00:00

  • Proteoglycan metabolism and viability of articular cartilage explants as modulated by the frequency of intermittent loading.

    abstract:OBJECTIVE:This study was designed to systematically determine whether and to what extent the frequency of intermittent loading modulates the biosynthesis and release of proteoglycans (PGs), and to assess chondrocyte viability within mature bovine articular cartilage explants exposed to different loading patterns. METH...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Sauerland K,Raiss RX,Steinmeyer J

    更新日期:2003-05-01 00:00:00

  • Stepwise preconditioning enhances mesenchymal stem cell-based cartilage regeneration through epigenetic modification.

    abstract:OBJECTIVE:This study is to investigate the functions and underlying mechanisms of mesenchymal stem cells (MSCs) underwent stepwise preconditioning in chondrogenic medium before expansion, then further explore their therapeutic effects in a surgically induced osteoarthritis (OA) model. METHODS:MSCs isolated from the ad...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Lin S,Lee WYW,Xu L,Wang Y,Chen Y,Ho KKW,Qin L,Jiang X,Cui L,Li G

    更新日期:2017-09-01 00:00:00

  • The evolving large-strain shear responses of progressively osteoarthritic human cartilage.

    abstract:OBJECTIVE:The composition and structure of articular cartilage evolves during the development and progression of osteoarthritis (OA) resulting in changing mechanical responses. We aimed to assess the evolution of the intrinsic, large-strain mechanics of human articular cartilage-governed by collagen and proteoglycan an...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Maier F,Lewis CG,Pierce DM

    更新日期:2019-05-01 00:00:00

  • Osteoarthritis year in review 2017: updates on imaging advancements.

    abstract:OBJECTIVE:This narrative review covers original research publications related to imaging advancements in osteoarthritis (OA) published in the English language between 1st April 2016 and 30th April 2017. METHODS:Relevant human studies (excluding pre-clinical and in vitro studies), were searched and selected from PubMed...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Hafezi-Nejad N,Demehri S,Guermazi A,Carrino JA

    更新日期:2018-03-01 00:00:00

  • Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review.

    abstract:OBJECTIVE:Summarize the comparative effectiveness of oral non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in reducing knee osteoarthritis (OA) pain. METHODS:Two reviewers independently screened reports of randomized controlled trials (RCTs), published in English between 1982 and 2015, evaluating oral NSAIDs...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Smith SR,Deshpande BR,Collins JE,Katz JN,Losina E

    更新日期:2016-06-01 00:00:00