Abstract:
OBJECTIVE:To determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI). DESIGN:Seventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiographic evidence of osteoarthritis (OA) and constant muscle strength over 48 months as measured by isometric knee extension testing were included. Baseline right thigh muscle CSAs were assessed on axial T1-weighted magnetic resonance (MR) images, and extensor to flexor CSA ratios were calculated. Degenerative knee abnormalities at baseline and 48-months were graded on right knee 3T MRIs using a modified whole organ MRI score (WORMS). Statistical analysis employed Student's t-tests and multivariable regression models adjusted for age, body mass index and gender. RESULTS:Extension strength was significantly and positively correlated with baseline thigh muscle CSA (r = 0.65, P < 0.001). Greater baseline total thigh muscle CSA was significantly associated with increase of cartilage WORMS scores over 48 months in patellar (P = 0.027) and trochlear (P = 0.038) compartments, but not in other knee compartments. Among specific muscle groups, CSA of extensors (P = 0.021) and vastus medialis (VM) (P = 0.047) were associated with patellar cartilage increase in WORMS. Baseline E/F ratio had a significant positive association with patellar WORMS cartilage score increase over 48 months, P = 0.0015. There were no other significant associations between muscle CSA/ratios and increase in WORMS scores. CONCLUSION:Maintenance of proper extensor to flexor muscle balance about the knee through decreased E/F ratios may slow patellofemoral cartilage deterioration, while higher extensor and VM CSA may increase patellofemoral cartilage loss.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Goldman LH,Tang K,Facchetti L,Heilmeier U,Joseph GB,Nevitt MC,McCulloch CE,Souza RB,Link TMdoi
10.1016/j.joca.2016.07.004subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2082-2091issue
12eissn
1063-4584issn
1522-9653pii
S1063-4584(16)30180-7journal_volume
24pub_type
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journal_title:Osteoarthritis and cartilage
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pub_type: 杂志文章,评审
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journal_title:Osteoarthritis and cartilage
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journal_title:Osteoarthritis and cartilage
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-09-01 00:00:00
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2019-02-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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更新日期:2010-12-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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journal_title:Osteoarthritis and cartilage
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journal_title:Osteoarthritis and cartilage
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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更新日期:2013-11-01 00:00:00
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更新日期:2018-03-01 00:00:00
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journal_title:Osteoarthritis and cartilage
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更新日期:2008-09-01 00:00:00
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