Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months - data from the Osteoarthritis Initiative.


OBJECTIVE:To determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI). DESIGN:Seventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiographic evidence of osteoarthritis (OA) and constant muscle strength over 48 months as measured by isometric knee extension testing were included. Baseline right thigh muscle CSAs were assessed on axial T1-weighted magnetic resonance (MR) images, and extensor to flexor CSA ratios were calculated. Degenerative knee abnormalities at baseline and 48-months were graded on right knee 3T MRIs using a modified whole organ MRI score (WORMS). Statistical analysis employed Student's t-tests and multivariable regression models adjusted for age, body mass index and gender. RESULTS:Extension strength was significantly and positively correlated with baseline thigh muscle CSA (r = 0.65, P < 0.001). Greater baseline total thigh muscle CSA was significantly associated with increase of cartilage WORMS scores over 48 months in patellar (P = 0.027) and trochlear (P = 0.038) compartments, but not in other knee compartments. Among specific muscle groups, CSA of extensors (P = 0.021) and vastus medialis (VM) (P = 0.047) were associated with patellar cartilage increase in WORMS. Baseline E/F ratio had a significant positive association with patellar WORMS cartilage score increase over 48 months, P = 0.0015. There were no other significant associations between muscle CSA/ratios and increase in WORMS scores. CONCLUSION:Maintenance of proper extensor to flexor muscle balance about the knee through decreased E/F ratios may slow patellofemoral cartilage deterioration, while higher extensor and VM CSA may increase patellofemoral cartilage loss.


Goldman LH,Tang K,Facchetti L,Heilmeier U,Joseph GB,Nevitt MC,McCulloch CE,Souza RB,Link TM




Has Abstract


2016-12-01 00:00:00














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    pub_type: 杂志文章


    authors: Novakofski KD,Berg LC,Bronzini I,Bonnevie ED,Poland SG,Bonassar LJ,Fortier LA

    更新日期:2015-07-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1999-09-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2018-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2020-06-01 00:00:00

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    更新日期:2019-12-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2016-11-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审


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    更新日期:2017-06-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章,随机对照试验


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    pub_type: 杂志文章,多中心研究


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    更新日期:2006-12-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2005-09-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2002-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Warnecke D,Balko J,Haas J,Bieger R,Leucht F,Wolf N,Schild NB,Stein SEC,Seitz AM,Ignatius A,Reichel H,Mizaikoff B,Dürselen L

    更新日期:2020-11-01 00:00:00

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    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2015-11-01 00:00:00