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Diffusion of Gd-DTPA²⁻ into articular cartilage.

Abstract：

OBJECTIVES:The delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) technique is a method proposed for non-invasive measurement of cartilage glycosaminoglycan (GAG) content. In this method, gadopentetate (Gd-DTPA²⁻) is assumed to distribute in cartilage in inverse relation to the GAG distribution, thus allowing quantification of the GAG content. For accurate GAG quantification, the kinetics of Gd-DTPA²⁻ in articular cartilage is of critical importance. However, the diffusion of Gd-DTPA²⁻ has not been systematically studied over long time periods using MRI-feasible gadopentetate concentrations. Thus, the present study aims to investigate the diffusion of gadopentetate into cartilage in vitro in intact and enzymatically degraded cartilage. METHODS:The diffusion of gadopentetate into bovine articular cartilage was investigated at 9.4 T over 18-h time period using repeated T(1) measurements in two models, (1) comparing intact and trypsin-treated tissue and (2) assessing the effect of penetration direction. The diffusion process was further assessed by determining the gadopentetate flux and diffusivity. The results were compared with histological and biochemical reference methods. RESULTS AND CONCLUSIONS:The results revealed that passive diffusion of Gd-DTPA²⁻ was significantly slower than previously assumed, leading to overestimation of the GAG content at equilibrating times of few hours. Moreover, Gd-DTPA²⁻ distribution was found to depend not only on GAG content, but also on collagen content and diffusion direction. Interestingly, the dGEMRIC technique was found to be most sensitive to cartilage degradation in the early stages of diffusion process, suggesting that full equilibrium between gadopentetate and cartilage may not be required in order to detect cartilage degeneration.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Salo EN,Nissi MJ,Kulmala KA,Tiitu V,Töyräs J,Nieminen MT

doi

10.1016/j.joca.2011.11.016

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

117-26

issue

2

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(11)00328-1

journal_volume

20

pub_type

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