Cartilage degeneration in different human joints.

abstract：OBJECTIVE:To compare femorotibial cartilage thickness changes over a 2- vs a 1-year observation period in knees with radiographic knee osteoarthritis (OA). METHODS:One knee of 346 Osteoarthritis Initiative (OAI) participants was studied at three time points [baseline (BL), year-1 (Y1), year-2 (Y2) follow-up]: 239 usin...

journal_title：Osteoarthritis and cartilage

authors： Wirth W,Larroque S,Davies RY,Nevitt M,Gimona A,Baribaud F,Lee JH,Benichou O,Wyman BT,Hudelmaier M,Maschek S,Eckstein F,OA Initiative Investigators Group.

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To compare the population prevalence, inter-relationships, risk factor profiles and clinical characteristics of subsets of symptomatic hand osteoarthritis (OA) with a view to understanding their relative frequency and distinctiveness. METHOD:1076 community-dwelling adults with hand symptoms (60% women, mean ...

journal_title：Osteoarthritis and cartilage

authors： Marshall M,Peat G,Nicholls E,van der Windt D,Myers H,Dziedzic K

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI) is a three-dimensional imaging technique with unparalleled ability to evaluate articular cartilage. This report reviews the current status of morphological assessment of cartilage with quantitative MRI (qMRI), and its relevance for identifying disease status, and monitoring pr...

journal_title：Osteoarthritis and cartilage

authors： Eckstein F,Cicuttini F,Raynauld JP,Waterton JC,Peterfy C

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to develop an algorithm to semi-automatically segment the meniscus in a series of magnetic resonance (MR) images to use for normal knees and those with moderate osteoarthritis (OA). METHOD:The segmentation method was developed then evaluated on 10 baseline MR images obtained from s...

journal_title：Osteoarthritis and cartilage

authors： Swanson MS,Prescott JW,Best TM,Powell K,Jackson RD,Haq F,Gurcan MN

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Biomarkers provide useful diagnostic information by detecting cartilage degradation in osteoarthritis (OA), reflecting disease-relevant biological activity and predicting the course of disease progression. They also serve as surrogate endpoints in the drug discovery process. The aim of this narrative review was...

journal_title：Osteoarthritis and cartilage

authors： Mobasheri A

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:This study examined the effects of reduced and elevated weight bearing on post-traumatic osteoarthritis (PTOA) development, locomotor joint kinematics, and degree of voluntary activity in rats following medial meniscal transection (MMT). DESIGN:Twenty-one adult rats were subjected to MMT surgery of the left ...

journal_title：Osteoarthritis and cartilage

authors： Tsai LC,Cooper ES,Hetzendorfer KM,Warren GL,Chang YH,Willett NJ

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the site-dependent changes in the structure and function of articular cartilage in the lapine knee joint at a very early stage of osteoarthritis (OA), created experimentally by anterior cruciate ligament transection (ACLT). METHODS:Unilateral ACLT was performed in eig...

journal_title：Osteoarthritis and cartilage

authors： Mäkelä JT,Rezaeian ZS,Mikkonen S,Madden R,Han SK,Jurvelin JS,Herzog W,Korhonen RK

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) are a promising cell type for the repair of damaged cartilage in osteoarthritis (OA). However, OA synovial fluid and factors secreted by synovium impede chondrogenic differentiation of MSCs, and the mechanism responsible for this effect remains unclear. In this study, we sought t...

journal_title：Osteoarthritis and cartilage

authors： Fahy N,de Vries-van Melle ML,Lehmann J,Wei W,Grotenhuis N,Farrell E,van der Kraan PM,Murphy JM,Bastiaansen-Jenniskens YM,van Osch GJ

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:To examine the in situ distributions of vitamin D receptors (VDR) and matrix metalloproteinases (MMPs) in osteoarthritic cartilage for comparison with non-arthritic, normal cartilage; and to assess the in vitro effects of 1alpha,25 dihydroxyvitaminD(3)(1alpha,25(OH)(2)D(3)) on MMPs-1, -3 and -9 and prostagla...

journal_title：Osteoarthritis and cartilage

authors： Tetlow LC,Woolley DE

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was to examine the...

journal_title：Osteoarthritis and cartilage

authors： Harding GT,Hubley-Kozey CL,Dunbar MJ,Stanish WD,Astephen Wilson JL

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Diacetylrhein or diacerein has shown efficacy in the treatment of both major forms of osteoarthritis (OA), coxarthrosis as well as gonarthrosis, improving clinical symptoms of the disease (pain reduction and algo-functional index). Both in-vitro and animal models studies suggest that diacerein may have also d...

journal_title：Osteoarthritis and cartilage

authors： Felisaz N,Boumediene K,Ghayor C,Herrouin JF,Bogdanowicz P,Galerra P,Pujol JP

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:Cam hip morphology is associated with femoroacetabular impingement (FAI) syndrome and causes hip osteoarthritis (OA). We aimed to assess the prevalence of cam hip morphology in a sample representative of the general population, using a measure with a predefined diagnostic accuracy. DESIGN:Patients aged 16-65...

journal_title：Osteoarthritis and cartilage

authors： Dickenson EJ,Wall PDH,Hutchinson CE,Griffin DR

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Summarize the comparative effectiveness of oral non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in reducing knee osteoarthritis (OA) pain. METHODS:Two reviewers independently screened reports of randomized controlled trials (RCTs), published in English between 1982 and 2015, evaluating oral NSAIDs...

journal_title：Osteoarthritis and cartilage

authors： Smith SR,Deshpande BR,Collins JE,Katz JN,Losina E

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Little is known about how static standing balance changes post total knee arthroplasty (TKA). The primary aim of this study was to examine the sensitivity to change and redundancy of center of pressure (COP) variables post-TKA. The secondary aim was to compare the sensitivity of these measures to standard cli...

journal_title：Osteoarthritis and cartilage

authors： Clark RA,Seah FJ,Chong HC,Poon CL,Tan JW,Mentiplay BF,Pua YH

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN:Six experimental groups included norm...

journal_title：Osteoarthritis and cartilage

authors： Hulmes DJ,Marsden ME,Strachan RK,Harvey RE,McInnes N,Gardner DL

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To employ a magnetic resonance (MR) imaging technique for quantitative assessment of thin cartilage layers, and to validate the cartilage volume and thickness measurements. METHODS:We investigated 10 normal elbow joints (age 20 to 69 years) with a 3D gradient echo sequence with selective water excitation (TR...

journal_title：Osteoarthritis and cartilage

authors： Graichen H,Springer V,Flaman T,Stammberger T,Glaser C,Englmeier KH,Reiser M,Eckstein F

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To examine the effects of anterior cruciate ligament (ACL) insufficiency, and subsequent bisphosphonate (BP) antiresorptive therapy, on the bone mineral interface at the enthesis of remaining ligamentous restraints. METHODS:We measured bone mineral geometry (and subsequent adaptation) at the medial collatera...

journal_title：Osteoarthritis and cartilage

authors： Doschak MR,LaMothe JM,Cooper DM,Hallgrimsson B,Hanley DA,Bray RC,Zernicke RF

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To update our earlier systematic review which evaluated all published randomized controlled trials (RCTs) evaluating pharmacological and non-pharmacological therapies in patients with hand osteoarthritis (OA). Surgical therapies were not evaluated. METHOD:RCTs published between August 2004 and February 2008 ...

journal_title：Osteoarthritis and cartilage

authors： Mahendira D,Towheed TE

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Solutes and interstitial water are naturally transported from cartilage by load-induced interstitial fluid pressures. Fluid and solute recovery during joint articulation have been primarily attributed to passive diffusion and mechanical 'pumping' from dynamic loading. This paper tests if the sliding action of...

journal_title：Osteoarthritis and cartilage

authors： Graham BT,Moore AC,Burris DL,Price C

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Because articular cartilage has limited ability to repair itself, treatment of (osteo)chondral lesions remains a clinical challenge. We aimed to evaluate how well a tissue-engineered cartilage-like implant, derived from chondrocytes cultured in a novel patented, scaffold-free bioreactor system, would perform ...

journal_title：Osteoarthritis and cartilage

authors： Mainil-Varlet P,Rieser F,Grogan S,Mueller W,Saager C,Jakob RP

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:This study investigates the long-term changes of the periarticular bone, including cancellous bone and the subchondral plate, in an anterior cruciate ligament (ACL)-transected cat for post-traumatic osteoarthritis (OA). These periarticular bone changes are related to the health of all knee tissues including ...

journal_title：Osteoarthritis and cartilage

authors： Boyd SK,Müller R,Leonard T,Herzog W

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To elucidate variations in tissue ultrastructure and incidence of pathology between fibromodulin (FM)-null mice and wild-type (WT) animals. DESIGN:FM-null and WT siblings from different age groups were compared. Serial sections were made through paraffin-embedded whole knees and investigated histologically. ...

journal_title：Osteoarthritis and cartilage

authors： Gill MR,Oldberg A,Reinholt FP

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) play an important role in the regulation of chondrogenesis of mesenchymal stem cells, but their expression still remains unknown in human adipose-derived stem cells (hADSCs). In this study the miRNA expression profile during chondrogenic differentiation of hADSC and the potential mechanism...

journal_title：Osteoarthritis and cartilage

authors： Zhang Z,Kang Y,Zhang Z,Zhang H,Duan X,Liu J,Li X,Liao W

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Prevalence of ankle osteoarthritis (OA) is lower than that of knee OA, however, the molecular mechanisms underlying the difference remain unrevealed. In the present study, we developed mouse ankle OA models for use as tools to investigate pathophysiology of ankle OA and molecular characteristics of ankle cart...

journal_title：Osteoarthritis and cartilage

authors： Chang SH,Yasui T,Taketomi S,Matsumoto T,Kim-Kaneyama JR,Omiya T,Hosaka Y,Inui H,Omata Y,Yamagami R,Mori D,Yano F,Chung U,Tanaka S,Saito T

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of a prolonged and constant active TGF-beta expression by the synovial lining cells on cartilage and ligamentous joint structures in vivo. DESIGN:An adenoviral vector (AdTGF-beta1(223,225)) was used for the overexpression of active TGF-beta1 in knee joints of C57Bl/6 mice. RESULTS:...

journal_title：Osteoarthritis and cartilage

authors： Bakker AC,van de Loo FA,van Beuningen HM,Sime P,van Lent PL,van der Kraan PM,Richards CD,van den Berg WB

更新日期：2001-02-01 00:00:00

abstract：:We performed a case-controlled study to determine whether previous gynecological surgery is associated with severe osteoarthritis (OA) of the knee, the hip or the spine, as well as mild OA of the knee. Patients who underwent surgical treatment for OA were defined as having severe OA. Patients with knee pain and radiog...

journal_title：Osteoarthritis and cartilage

authors： Inoue K,Ushiyama T,Kim Y,Shichikawa K,Nishioka J,Hukuda S

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To determine the within- and between-patient variability in the concentrations of synovial fluid, serum and urine markers of joint tissue metabolism in a cohort of patients with knee pain and cartilage changes consistent with early-stage knee osteoarthritis. DESIGN:Samples of synovial fluid, serum, and urine...

journal_title：Osteoarthritis and cartilage

authors： Lohmander LS,Dahlberg L,Eyre D,Lark M,Thonar EJ,Ryd L

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:First, to assess the clinical effectiveness of hylan G-F 20 in an appropriate care treatment regimen (as defined by the American College of Rheumatology (ACR) 1995 guidelines) as measured by validated disease-specific outcomes and health-related quality of life endpoints for patients with osteoarthritis (OA) ...

journal_title：Osteoarthritis and cartilage

authors： Raynauld JP,Torrance GW,Band PA,Goldsmith CH,Tugwell P,Walker V,Schultz M,Bellamy N,Canadian Knee OA Study Group.

更新日期：2002-07-01 00:00:00

abstract：:Human articular cartilage cells were cultured in 1.5% agarose in Dulbecco's modified Eagle's medium (DMEM) with 10% fetal calf serum or in serum-free DMEM with 0.15% bovine serum albumin. 35S-aggrecan synthesis in serum-free DMEM was between 20% and 30% of the value observed in DMEM supplemented with 10% fetal calf se...

journal_title：Osteoarthritis and cartilage

authors： Verbruggen G,Malfait AM,Dewulf M,Broddelez C,Veys EM

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to assess the inter-observer reliability and intra-observer reproducibility of the Ahlbäck radiographic classification for knee osteoarthritis (OA). DESIGN:Ninety-six knee radiographs of patients with clinical signs of arthritis were evaluated and classified into five grades of Ahlbä...

journal_title：Osteoarthritis and cartilage

authors： Galli M,De Santis V,Tafuro L

更新日期：2003-08-01 00:00:00