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Three-dimensional hip cartilage quality assessment of morphology and dGEMRIC by planar maps and automated segmentation.

Abstract：

OBJECTIVE:The quantitative interpretation of hip cartilage magnetic resonance imaging (MRI) has been limited by the difficulty of identifying and delineating the cartilage in a three-dimensional (3D) dataset, thereby reducing its routine usage. In this paper a solution is suggested by unfolding the cartilage to planar two-dimensional (2D) maps on which both morphology and biochemical degeneration patterns can be investigated across the entire hip joint. DESIGN:Morphological TrueFISP and biochemical delayed gadolinium enhanced MRI of cartilage (dGEMRIC) hip images were acquired isotropically for 15 symptomatic subjects with mild or no radiographic osteoarthritis (OA). A multi-template based label fusion technique was used to automatically segment the cartilage tissue, followed by a geometric projection algorithm to generate the planar maps. The segmentation performance was investigated through a leave-one-out study, for two different fusion methods and as a function of the number of utilized templates. RESULTS:For each of the generated planar maps, various patterns could be seen, indicating areas of healthy and degenerated cartilage. Dice coefficients for cartilage segmentation varied from 0.76 with four templates to 0.82 with 14 templates. Regional analysis suggests even higher segmentation performance in the superior half of the cartilage. CONCLUSIONS:The proposed technique is the first of its kind to provide planar maps that enable straightforward quantitative assessment of hip cartilage morphology and dGEMRIC values. This technique may have important clinical applications for patient selection for hip preservation surgery, as well as for epidemiological studies of cartilage degeneration patterns. It is also shown that 10-15 templates are sufficient for accurate segmentation in this application.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Siversson C,Akhondi-Asl A,Bixby S,Kim YJ,Warfield SK

doi

10.1016/j.joca.2014.08.012

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1511-5

issue

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(14)01242-4

journal_volume

pub_type

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Three-dimensional hip cartilage quality assessment of morphology and dGEMRIC by planar maps and automated segmentation.