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In vivo serial joint space measurements during dynamic loading in a canine model of osteoarthritis.

Abstract：

OBJECTIVE:To devise a reliable, sensitive method to measure joint space in vivo during dynamic loading. Additionally, to determine if dynamic joint space changes were related to the severity of long-term cartilage damage. DESIGN:Subjects were 23 adult foxhounds (18 experimental, 5 control). Experimental subjects had surgically transected cranial cruciate ligaments (CCL). Dynamic joint space was serially measured in vivo over 2 years using a unique high speed stereo radiographic system in combination with subject-specific computed tomography reconstructions. RESULTS:Dynamic joint space was measured in vivo with a within-day precision of 0.09 mm. Half of the experimental subjects developed minor articular cartilage damage and the other half developed severe articular cartilage damage in the medial knee compartment. Joint space during treadmill running increased significantly in the minor damage group in both the medial (+0.61 mm, P = 0.036) and lateral (+0.84 mm, P = 0.002) compartments of the knee. Dynamic joint space in the severe damage group did not increase significantly on either the medial (+0.27 mm, P = 0.408) or lateral (+0.44 mm, P = 0.199) side. The majority of the change in joint space occurred the first year after CCL transection. Medial meniscus damage was related to severity of medial articular cartilage damage (tau = 0.447, P = 0.003). The minor damage group developed 73% of all osteophytes noted at dissection. CONCLUSIONS:This technique is a precise tool for measuring joint space serially in vivo under dynamic loading conditions. The data suggest decreased severity in long-term articular cartilage damage is related to: osteophyte formation, less severe medial meniscus damage and increased joint space the first 12 months after injury.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Anderst WJ,Les C,Tashman S

doi

10.1016/j.joca.2005.04.019

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

808-16

issue

9

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(05)00117-2

journal_volume

13

pub_type

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