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Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice.

Abstract：

OBJECTIVE:To determine the specificity and efficiency of the tamoxifen (TM)-induced Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. METHODS:Col2a1-CreER(T2) transgenic mice were bred with Rosa26 reporter mice. Two-week-old Col2a1-CreER(T2);R26R mice were administered TM for 5 days and were sacrificed 1 and 6 months after TM induction. X-Gal staining was performed. RESULTS:Efficient Cre-recombination is achieved in adult articular chondrocytes 1 and 6 months after TM induction. CONCLUSION:Our findings demonstrate that the Col2a1-CreER(T2) transgenic mouse model is a valuable tool to target genes specifically expressed in articular chondrocytes in a temporally controlled manner in adult mice.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Zhu M,Chen M,Lichtler AC,O'Keefe RJ,Chen D

doi

10.1016/j.joca.2007.08.001

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

129-30

issue

1

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(07)00279-8

journal_volume

16

pub_type

杂志文章

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