Relationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial.


OBJECTIVE:To explore effects of weight loss and maintenance on serum cartilage biomarkers denaturation neoepitope for Collagen2 (Coll2-1) and Fibulin3 fragment (Fib3-2), as well as correlations between Coll2-1 and Fib3-2 and symptomatic improvement, in a knee osteoarthritis (KOA) population. DESIGN:192 obese KOA patients followed a 16 week weight loss intervention and 52 weeks weight maintenance ( identifier: NCT00655941). Assessments were at 0, 8, 16 and 68 weeks. Serum Coll2-1 and Fib3-2 were determined with ELISA, and symptoms by the Knee Osteoarthritis Outcome Score (KOOS) questionnaire. Changes from week 0 and association between changes from baseline in body weight and Coll2-1, Fib3-2, and the 5 KOOS domains were assessed at all time points. RESULTS:Coll2-1 changes from baseline showed a decrease at week 8 (P = 0.0002), no change at week 16 (P = 0.49), and an increase at week 68 (P = 0.036). Fib3-2 showed an increase from baseline at week 8 (P = 0.0015) and 16 (P < 0.0001), but none at week 68 (P = 0.23). No statistically significant correlations were found between changes in body weight and Coll2-1 and Fib3-2 at any time point (r < 0.05; P > 0.49). At all time-points there were significant positive correlations between changes from baseline in Coll2-1 and in KOOSSports/Recreation (week 8, 16, 68: r = 0.17; P = 0.03; r = 0.16; P = 0.04; and r = 0.17; P = 0.04, respectively). CONCLUSION:The clinical improvement after a substantial weight loss and weight maintenance in KOA patients was not associated with decrease in markers of cartilage breakdown Coll2-1 or Fib3-2, even with indications of a slightly negative effect.


Bartels EM,Henrotin Y,Bliddal H,Centonze P,Henriksen M




Has Abstract


2017-10-01 00:00:00














  • Regulation of inflammatory and catabolic responses to IL-1β in rat articular chondrocytes by microRNAs miR-122 and miR-451.

    abstract:OBJECTIVE:miR-122 stimulates proliferation of growth plate chondrocytes whereas miR-451 stimulates terminal differentiation and matrix turnover. Here, we examined the potential of these microRNA as regulators of articular chondrocytes using an in vitro model of osteoarthritis. METHODS:miR-122 and miR-451 presence in r...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Scott KM,Cohen DJ,Hays M,Nielson DW,Grinstaff MW,Lawson TB,Snyder BD,Boyan BD,Schwartz Z

    更新日期:2021-01-01 00:00:00

  • Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative.

    abstract:OBJECTIVE:To compare femorotibial cartilage thickness changes over a 2- vs a 1-year observation period in knees with radiographic knee osteoarthritis (OA). METHODS:One knee of 346 Osteoarthritis Initiative (OAI) participants was studied at three time points [baseline (BL), year-1 (Y1), year-2 (Y2) follow-up]: 239 usin...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Wirth W,Larroque S,Davies RY,Nevitt M,Gimona A,Baribaud F,Lee JH,Benichou O,Wyman BT,Hudelmaier M,Maschek S,Eckstein F,OA Initiative Investigators Group.

    更新日期:2011-01-01 00:00:00

  • The cellular responses of articular cartilage to sharp and blunt trauma.

    abstract:OBJECTIVE:To determine the response of immature articular cartilage to both sharp and blunt trauma in terms of cell death, cell proliferation and matrix synthesis. DESIGN:Blunt wounds were made with a trephine in full depth immature bovine articular cartilage explants which were cut in half through the center of the t...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Redman SN,Dowthwaite GP,Thomson BM,Archer CW

    更新日期:2004-02-01 00:00:00

  • Osteoarthritis and the incidence of fracture in the United Kingdom: a retrospective cohort study of 258,696 patients.

    abstract:OBJECTIVE:The goal of this study was to analyze the relationship between osteoarthritis and the incidence of fracture in men and women aged ≥18 years followed in general practices in the United Kingdom. METHODS:This study included patients aged ≥18 years who had received an initial diagnosis of osteoarthritis in one o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Jacob L,Kostev K

    更新日期:2020-12-21 00:00:00

  • Ultrasonographic assessment of medial femoral cartilage deformation acutely following walking and running.

    abstract:OBJECTIVE:To determine the magnitude of medial femoral cartilage deformation using ultrasonography (US) following walking and running in healthy individuals. DESIGN:Twenty-five healthy participants with no history of osteoarthritis or knee injury volunteered for this study. Medial femoral cartilage thickness was asses...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Harkey MS,Blackburn JT,Davis H,Sierra-Arévalo L,Nissman D,Pietrosimone B

    更新日期:2017-06-01 00:00:00

  • Quantitative imaging of proteoglycan in cartilage using a gadolinium probe and microCT.

    abstract:OBJECTIVE:Micro-computed tomography (microCT) imaging has the potential to allow the three-dimensional (3D) visualization of cartilage morphology. However, cartilage intensity on a microCT image is weak because cartilage does not strongly attenuate X-rays. This work was designed to demonstrate that exposure of cartilag...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Cockman MD,Blanton CA,Chmielewski PA,Dong L,Dufresne TE,Hookfin EB,Karb MJ,Liu S,Wehmeyer KR

    更新日期:2006-03-01 00:00:00

  • Early intervention with Interleukin-1 Receptor Antagonist Protein modulates catabolic microRNA and mRNA expression in cartilage after impact injury.

    abstract:OBJECTIVE:The purpose of this controlled laboratory study was to determine the efficacy of Interleukin-1 Receptor Antagonist Protein (IRAP) treatment as an early intervention strategy by examining the changes in microRNA and mRNA expression in cartilage in an ex-vivo porcine knee joint impact model. METHODS:Custom imp...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Genemaras AA,Reiner T,Huang CY,Kaplan L

    更新日期:2015-11-01 00:00:00

  • Efficacy of intraarticular hyaluronic acid in patients with osteoarthritis--a prospective clinical trial.

    abstract:AIM:The goal of this study was to determine whether or not the intraarticular administration of hyaluronic acid can improve functional parameters, such as isokinetic muscle strength or total work and clinical test results in patients with osteoarthritis (OA) of the knee. METHOD:As part of a prospective, controlled stu...

    journal_title:Osteoarthritis and cartilage

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miltner O,Schneider U,Siebert CH,Niedhart C,Niethard FU

    更新日期:2002-09-01 00:00:00

  • Femoral trabecular bone of osteoarthritic and normal subjects in an age and sex matched group.

    abstract:OBJECTIVE:To describe changes to the cancellous structure of femoral bone from patients with severe primary osteoarthritis by comparison with age and sex matched controls. METHOD:Specimens were taken from 18 male and 18 female pairs. One of each pair was a normal control, the other having severe primary osteoarthritis...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Fazzalari NL,Parkinson IH

    更新日期:1998-11-01 00:00:00

  • Psychological health impact on 2-year changes in pain and function in persons with knee pain: data from the Osteoarthritis Initiative.

    abstract:OBJECTIVE:We determined whether baseline depressive symptoms, knee-related confidence and general psychological distress influenced changes in pain and function during 2 years of follow-up. DESIGN:We included persons in the Osteoarthritis Initiative (OAI) dataset with baseline pain of 1 or greater on a 0-10 scale in a...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,多中心研究


    authors: Riddle DL,Kong X,Fitzgerald GK

    更新日期:2011-09-01 00:00:00

  • Osteoarthritis year in review 2015: mechanics.

    abstract::Motivated by the conceptual framework of multi-scale biomechanics, this narrative review highlights recent major advances with a focus on gait and joint kinematics, then tissue-level mechanics, cell mechanics and mechanotransduction, matrix mechanics, and finally the nanoscale mechanics of matrix macromolecules. A lit...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Varady NH,Grodzinsky AJ

    更新日期:2016-01-01 00:00:00

  • Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system.

    abstract:INTRODUCTION:Articular cartilage matrix synthesis and degradation are dynamic processes that must be balanced for proper maintenance of the tissue. In osteoarthritis (OA), this balance is skewed toward degradation and ultimate loss of matrix. The transcriptional and/or activity levels of hundreds of genes are dysregula...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Arai M,Anderson D,Kurdi Y,Annis-Freeman B,Shields K,Collins-Racie LA,Corcoran C,DiBlasio-Smith E,Pittman DD,Dorner AJ,Morris E,LaVallie ER

    更新日期:2004-08-01 00:00:00

  • Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis.

    abstract:OBJECTIVE:The effects of mechanical deformation of intact cartilage tissue on chondrocyte biosynthesis in situ have been well documented, but the mechanotransduction pathways that regulate such phenomena have not been elucidated completely. The goal of this study was to examine the effects of tissue deformation on the ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Szafranski JD,Grodzinsky AJ,Burger E,Gaschen V,Hung HH,Hunziker EB

    更新日期:2004-12-01 00:00:00

  • Contrast enhanced imaging of human meniscus using cone beam CT.

    abstract:OBJECTIVE:Meniscal injuries can lead to mechanical overloading of articular cartilage and eventually to knee osteoarthritis. The objective was to evaluate the potential of contrast enhanced computed tomography (CECT) to image contrast agent (CA) diffusion in human menisci with a clinical cone beam CT scanner. DESIGN:I...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Honkanen JT,Danso EK,Suomalainen JS,Tiitu V,Korhonen RK,Jurvelin JS,Töyräs J

    更新日期:2015-08-01 00:00:00

  • Effects of treadmill running and limb immobilization on knee cartilage degeneration and locomotor joint kinematics in rats following knee meniscal transection.

    abstract:OBJECTIVE:This study examined the effects of reduced and elevated weight bearing on post-traumatic osteoarthritis (PTOA) development, locomotor joint kinematics, and degree of voluntary activity in rats following medial meniscal transection (MMT). DESIGN:Twenty-one adult rats were subjected to MMT surgery of the left ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Tsai LC,Cooper ES,Hetzendorfer KM,Warren GL,Chang YH,Willett NJ

    更新日期:2019-12-01 00:00:00

  • Estrogen reduces mechanical injury-related cell death and proteoglycan degradation in mature articular cartilage independent of the presence of the superficial zone tissue.

    abstract:OBJECTIVE:To study the effect of 17β-estradiol (E2) and the superficial zone (SFZ) on cell death and proteoglycan degradation in articular cartilage after a single injurious compression in vitro. METHOD:Cartilage explants from the femoropatellar groove of 2 year old cows with or without the SFZ were cultured serum-fre...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Imgenberg J,Rolauffs B,Grodzinsky AJ,Schünke M,Kurz B

    更新日期:2013-11-01 00:00:00

  • A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia.

    abstract:OBJECTIVE:To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density (sBMD). METHODS:A consecutive sample of 50 male and female participants from a population-based longitudinal study had sBMD assessed using dual energy X-ray absorptiometry scans. Ant...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Dore D,Ding C,Jones G

    更新日期:2008-12-01 00:00:00

  • Sensitivity to change of the functional index for hand osteoarthritis.

    abstract:BACKGROUND:The functional index for hand osteoarthritis (FIHOA), a 10-item investigator-administered questionnaire, was validated in 1995. It is relevant, reliable and has good external and internal validities. OBJECTIVE:To assess the sensitivity to change over time of the FIHOA. PATIENTS/METHODS: PATIENTS:symptomat...

    journal_title:Osteoarthritis and cartilage

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dreiser RL,Maheu E,Guillou GB

    更新日期:2000-01-01 00:00:00

  • A positive association of smoking and articular knee joint cartilage in healthy people.

    abstract:OBJECTIVE:To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with tibial cartilage volume and tibiofemoral cartilage defects. METHODS:Two hundred and ninety-seven healthy adult subjects were recruited from an existing cohort examining healthy aging, the Me...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Racunica TL,Szramka M,Wluka AE,Wang Y,English DR,Giles GG,O'Sullivan R,Cicuttini FM

    更新日期:2007-05-01 00:00:00

  • Changes in biomechanical properties of tendons and ligaments from joint disuse.

    abstract:OBJECTIVE:The purpose of this paper is to review changes in the biomechanical properties of tendons and ligaments from joint disuse. METHOD:We have reviewed 37 experimental studies on joint disuse, which have been carried out with various models of disuse and with various animals. RESULTS:Immobilization of joints has...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Yasuda K,Hayashi K

    更新日期:1999-01-01 00:00:00

  • Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice.

    abstract:OBJECTIVE:Lipocalin-2 (LCN2) is a recently characterized adipokine that is upregulated in chondrocytes treated with pro-inflammatory mediators and in the synovial fluid of osteoarthritis (OA) patients. Here, we explored the in vivo functions of LCN2 in OA cartilage destruction in mice. METHODS:The expression levels of...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Choi WS,Chun JS

    更新日期:2017-03-01 00:00:00

  • A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis.

    abstract:OBJECTIVE:To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. METHODS:Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析


    authors: Srikanth VK,Fryer JL,Zhai G,Winzenberg TM,Hosmer D,Jones G

    更新日期:2005-09-01 00:00:00

  • Sliding enhances fluid and solute transport into buried articular cartilage contacts.

    abstract:OBJECTIVE:Solutes and interstitial water are naturally transported from cartilage by load-induced interstitial fluid pressures. Fluid and solute recovery during joint articulation have been primarily attributed to passive diffusion and mechanical 'pumping' from dynamic loading. This paper tests if the sliding action of...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Graham BT,Moore AC,Burris DL,Price C

    更新日期:2017-12-01 00:00:00

  • Modeling and predicting osteoarthritis progression: data from the osteoarthritis initiative.

    abstract:OBJECTIVE:The goal of this study was to model the longitudinal progression of knee osteoarthritis (OA) and build a prognostic tool that uses data collected in 1 year to predict disease progression over 8 years. DESIGN:To model OA progression, we used a mixed-effects mixture model and 8-year data from the Osteoarthriti...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Halilaj E,Le Y,Hicks JL,Hastie TJ,Delp SL

    更新日期:2018-12-01 00:00:00

  • Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement.

    abstract:OBJECTIVE:The European Society on Clinical and Economic aspects of Osteoporosis and Osteoarthritis (ESCEO) organised a working group to evaluate the need for updating the current European guideline on clinical investigation of drugs used in the treatment of osteoarthritis (OA). DESIGN:Areas of potential attention were...

    journal_title:Osteoarthritis and cartilage

    pub_type: 共识发展会议,杂志文章,评审


    authors: Reginster JY,Reiter-Niesert S,Bruyère O,Berenbaum F,Brandi ML,Branco J,Devogelaer JP,Herrero-Beaumont G,Kanis J,Maggi S,Maheu E,Richette P,Rizzoli R,Cooper C

    更新日期:2015-12-01 00:00:00

  • Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma.

    abstract:OBJECTIVE:Chondrocyte death, a notable feature of osteoarthritis, may play a role in the initiation of cartilage degeneration. The present study was aimed at uncovering the nature and involvement of cell death in the initiation of cartilage degeneration induced by mechanical trauma. METHODS:Articular cartilage discs o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Huser CA,Peacock M,Davies ME

    更新日期:2006-10-01 00:00:00

  • Estimating contextual effect in nonpharmacological therapies for pain in knee osteoarthritis: a systematic analytic review.

    abstract:OBJECTIVE:Conduct a systematic review and use meta-analytic techniques to estimate the proportion of total treatment effect that can be attributable to contextual effects (PCE) in adults receiving nonpharmacological, nonsurgical (NPNS) treatments for knee osteoarthritis (OA). DESIGN:We reviewed the published literatur...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审


    authors: Chen AT,Shrestha S,Collins JE,Sullivan JK,Losina E,Katz JN

    更新日期:2020-09-01 00:00:00

  • Mechanical symptoms as an indication for knee arthroscopy in patients with degenerative meniscus tear: a prospective cohort study.

    abstract:OBJECTIVE:According to prevailing consensus, patients with mechanical symptoms are those considered to most likely benefit from arthroscopic surgery. The aim of this study was to determine the value of using patients' pre-operative self-reports of mechanical symptoms as a justification surgery in patients with degenera...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Sihvonen R,Englund M,Turkiewicz A,Järvinen TL

    更新日期:2016-08-01 00:00:00

  • Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain.

    abstract:OBJECTIVES:To determine the natural history of cartilage damage and of osteoarthritis (OA) progression using magnetic resonance imaging (MRI); to evaluate whether OA progression varies by stage of disease. METHODS:A population-based cohort with knee pain was assessed clinically, with X-ray (Kellgren-Lawrence [KL] grad...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Cibere J,Sayre EC,Guermazi A,Nicolaou S,Kopec JA,Esdaile JM,Thorne A,Singer J,Wong H

    更新日期:2011-06-01 00:00:00

  • Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.

    abstract:OBJECTIVE:The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN:Six experimental groups included norm...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章


    authors: Hulmes DJ,Marsden ME,Strachan RK,Harvey RE,McInnes N,Gardner DL

    更新日期:2004-03-01 00:00:00